Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

Abstract: The present disclosure provides, in various embodiments, stable injectable particle suspensions of therapeutic biologics and hyaluronan degrading agents that permit administration without the need for resuspension. In particular, the compositions disclosed herein are highly concentrated, low-volume injectable particle suspensions that increase bioavailability of therapeutic biologics.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: A method of passing an object on the side of the road by receiving a first signal from a first sensor configured to detect a presence of the object positioned on a shoulder of a road; determining a first value; assigning a first confidence value to a confidence level, wherein the first confidence value is associated with the first value; responsive to the first confidence value exceeding a confidence threshold, adjusting a first operating parameter of a vehicle; responsive to entering a threshold range of the object, receiving a second signal from a second sensor; determining a second value associated with the second signal; assigning a second confidence value to the confidence level, wherein the second confidence value is associated with the second value; responsive to the second confidence value exceeding a second confidence threshold, adjusting a second operating parameter of the vehicle.

Abstract: Embodiments herein include systems and methods of generating lane selection cost values to control autonomous vehicles to accommodate merging vehicles in a tapering lane (or merge lane). An autonomy system can identify a tapering lane in map data and detect a merging vehicle situated in the tapering lane using perception sensor data. The autonomy system includes a lane-selection cost function that generates lane-selection cost values for the lanes available to the automated vehicle, which the autonomy system references to determine whether to continue traveling a current lane or change lanes into an adjacent lane. The lane-selection cost function may apply a courtesy weight when detecting the merging vehicle, such that the autonomy system causes the automated vehicle to change lanes as a courtesy to the merging vehicle, but without overriding other safety-related factors of the lane-selection cost function or trajectory planning functions.

Abstract: Embodiments herein include systems and methods of generating lane selection cost values to control autonomous vehicles to accommodate merging vehicles in a tapering lane (or merge lane). An autonomy system can identify a tapering lane in map data and detect a merging vehicle situated in the tapering lane using perception sensor data. The autonomy system includes a lane-selection cost function that generates lane-selection cost values for the lanes available to the automated vehicle, which the autonomy system references to determine whether to continue traveling a current lane or change lanes into an adjacent lane. The lane-selection cost function may apply a courtesy weight when detecting the merging vehicle, such that the autonomy system causes the automated vehicle to change lanes as a courtesy to the merging vehicle, but without overriding other safety-related factors of the lane-selection cost function or trajectory planning functions.

Abstract: Systems and methods of generating lane selection cost maps to control autonomous vehicles are disclosed. An autonomous vehicle system can receive a plurality of cost values from a plurality of components of an autonomous vehicle; generate a lane selection cost map based on the plurality of cost values; determining that the autonomous vehicle should change lanes based on the lane selection cost map; and transmit a command that causes the autonomous vehicle to change lanes responsive to determining that the autonomous vehicle should change lanes.

Abstract: A system includes a coolant system and a refrigerant system. The coolant system is in fluid communication with power electronics, a battery pack, and a cabin. The refrigerant system only interfaces with coolant from the coolant system, and wherein all cabin heat exchange and all refrigerant heat exchange is through coolant.

Abstract: A method of manufacturing a via-in-via vertical interconnect in a printed circuit board (PCB), including: drilling a first hole through the PCB; drilling a second hole into a top side of the PCB; plating the first hole and the second hole with a conductive material to form an outer layer; drilling a third hole through the PCB wherein a portion of the plating is removed between the first hole and the second hole; filling the first, second, and third holes with an outer filler; drilling a fourth hole through the outer filler; plating the fourth hole with a conductive material to form an inner layer; filling the fourth hole with an inner filler; forming a via-in-via pad on top of the inner filler connected to the inner layer; and drilling a fifth hole through the bottom of the PCB along the fourth hole to remove a portion of the inner filler and inner layer wherein the top of the fifth hole is below the internal layer.

Abstract: The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.

Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

Abstract: An adjustable reclining chair having zero wall clearance has a frame and an adjustable support platform with a plurality of articulated support sections pivotally mounted with respect to one another for relative angular adjustment. An actuator means for effecting co-ordinated movement of said support sections to reconfigure the chair between a seated position and a sleeping position in which the articulated supporting sections lie in a substantially horizontal plane (H). One of the articulated support sections is a seat support inclined relative to the horizontal plane when the chair is in the seated position and substantially in the horizontal plane when the chair is in the sleeping position.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes a first heat exchanger, a first region of a second heat exchanger, a third heat exchanger, a fourth heat exchanger, a compressor, a vapor generator, and a four-way valve. The compressor includes a low-pressure inlet, a mid-pressure inlet, and an outlet. The vapor generator is positioned downstream of the outlet of the compressor and upstream of both the low-pressure inlet and the mid-pressure inlet. The four-way valve is positioned immediately upstream of the first heat exchanger. At least one component chosen from the first heat exchanger, the second heat exchanger, and the vapor generator is free from compressor-driven flow of the first heat exchange fluid during a first predetermined set of heating modes of operation of the heat pump and a first predetermined set of cooling modes of operation of the heat pump.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: A method may include storing and updating published resource entitlements for a plurality of client devices at a computing device. The method may also include using a plurality of virtual delivery appliances to receive connection requests from the client devices, with the connection requests including connection leases having associated resource entitlements the client devices are respectively permitted to access, and request validation of the connection leases from the computing device. At the computing device, responsive to validation requests from the virtual delivery appliances, the connection leases may be compared to the updated published resource entitlements and validated based thereon. At the virtual delivery appliances, the client devices may be provided with access to virtual sessions corresponding to the published resource entitlements responsive to the virtual session request validations from the computing device.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes a compressor, a first region of a first heat exchanger, a second heat exchanger, and a bypass branch. The compressor includes a low-pressure inlet, a mid-pressure inlet, and an outlet. The first heat exchanger is positioned downstream of the outlet of the compressor. The second heat exchanger is positioned downstream of the first heat exchanger. The bypass branch includes an entrance and an exit. The entrance to the bypass branch is positioned downstream of the outlet of the compressor and upstream of the first region of the first heat exchanger. The exit of the bypass branch is positioned upstream of the second heat exchanger.

Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

Abstract: A method of detecting and mitigating icing of an outside heat exchanger in an electric vehicle including a heat pump. Various sources of heat may be utilized to de-ice an outside heat exchanger of the heat pump. The sources of heat may include one or more of vehicle electronics, a high voltage (“HV”) battery, and an HV coolant heater. Pre-defined criteria may be utilized to determine the actions to be taken to de-ice the outside heat exchanger and/or to prevent icing of the outside heat exchanger.