Abstract: A method may include storing and updating published resource entitlements for a plurality of client devices at a computing device. The method may also include using a plurality of virtual delivery appliances to receive connection requests from the client devices, with the connection requests including connection leases having associated resource entitlements the client devices are respectively permitted to access, and request validation of the connection leases from the computing device. At the computing device, responsive to validation requests from the virtual delivery appliances, the connection leases may be compared to the updated published resource entitlements and validated based thereon. At the virtual delivery appliances, the client devices may be provided with access to virtual sessions corresponding to the published resource entitlements responsive to the virtual session request validations from the computing device.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes a compressor, a first region of a first heat exchanger, a second heat exchanger, and a bypass branch. The compressor includes a low-pressure inlet, a mid-pressure inlet, and an outlet. The first heat exchanger is positioned downstream of the outlet of the compressor. The second heat exchanger is positioned downstream of the first heat exchanger. The bypass branch includes an entrance and an exit. The entrance to the bypass branch is positioned downstream of the outlet of the compressor and upstream of the first region of the first heat exchanger. The exit of the bypass branch is positioned upstream of the second heat exchanger.

Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

Abstract: A method of detecting and mitigating icing of an outside heat exchanger in an electric vehicle including a heat pump. Various sources of heat may be utilized to de-ice an outside heat exchanger of the heat pump. The sources of heat may include one or more of vehicle electronics, a high voltage (“HV”) battery, and an HV coolant heater. Pre-defined criteria may be utilized to determine the actions to be taken to de-ice the outside heat exchanger and/or to prevent icing of the outside heat exchanger.

Abstract: A system and method for matching a plurality of components to a plurality of printed circuit board (PCB), including: characterizing the warpage characteristics of the plurality of components; characterizing the warpage characteristics of a site of the plurality of PCBs where the component will be placed; determining viable component and PCB pairings based upon the component warpage characteristics and the PCB warpage characteristics; and assembling the pairs of components and PCBs.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes a first heat exchanger, a first region of a second heat exchanger, a third heat exchanger, a fourth heat exchanger, a compressor, a vapor generator, an accumulator, a first expansion valve, and a first three-way valve. The compressor includes a low-pressure inlet, a mid-pressure inlet, and an outlet. The vapor generator is positioned downstream of the outlet of the compressor and upstream of both the low-pressure inlet and the mid-pressure inlet. The vapor generator includes a first region and a second region. The accumulator is positioned immediately upstream of the compressor. The accumulator includes an inlet and an outlet. The first expansion valve is positioned upstream of the accumulator. The first expansion valve includes an inlet and an outlet. The first three-way valve is positioned immediately downstream of the first expansion valve and immediately upstream of the accumulator.

Abstract: In some examples, a system receives an input graph representation of one or more query plans for one or more database queries, and generates, by an embedding machine learning model based on the input graph representation, a feature vector that provides a distributed representation of the one or more query plans. The system determines, using the feature vector, one or more user behaviors and/or workload characteristics of one or more workloads in one or more database systems.

Abstract: A circuit assembly, including: an integrated circuit (IC) with a plurality of connection pads; a ball grid array (BGA) including a plurality of solder balls arranged in an array, where plurality of solder balls are configured to connect the plurality of connections pads to a plurality of connections pads on a PCB; and a BGA spacer configured to fit among the plurality of solder balls, wherein the BGA spacer has a width based upon a height and spacing of the plurality of solder balls and a height based upon a height and spacing of the plurality of solder balls and a minimum distance between the IC and the PCB to prevent shorting of adjacent solder balls.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: Systems, methods and devices are provided for registering DNS hostnames of Internet host devices for very large domain zones (VLZ) stored on a DNS server on a network, including setting a pseudo-zone as the VLZ, intercepting DNS updates to the pseudo-zone, mapping the entries in the pseudo-zone into a hierarchy of real parent zones and sub-zones using a mapping formula, and translating DNS updates to the pseudo-zone from an original fully qualified domain name (FQDN) into a at least one new FQDNs and adding the at least one new FQDNs to an authoritative DNS Server.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes a first heat exchanger, a first region of a second heat exchanger, a third heat exchanger, a fourth heat exchanger, a compressor, a vapor generator, an accumulator, a first expansion valve, and a first three-way valve. The compressor includes a low-pressure inlet, a mid-pressure inlet, and an outlet. The vapor generator is positioned downstream of the outlet of the compressor and upstream of both the low-pressure inlet and the mid-pressure inlet. The vapor generator includes a first region and a second region. The accumulator is positioned immediately upstream of the compressor. The accumulator includes an inlet and an outlet. The first expansion valve is positioned upstream of the accumulator. The first expansion valve includes an inlet and an outlet. The first three-way valve is positioned immediately downstream of the first expansion valve and immediately upstream of the accumulator.

Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes an accumulator having an inlet and an outlet, a compressor, a first heat exchanger, and a first coupling point. The compressor includes a low-pressure inlet and an outlet. The low-pressure inlet is downstream of the outlet of the accumulator. The first heat exchanger includes an inlet and an outlet. The first coupling point is positioned immediately downstream of the outlet of the accumulator and immediately upstream of the low-pressure inlet of the compressor. The first coupling point is immediately downstream of the outlet of the first heat exchanger such that a first heat exchange fluid circulating through the refrigerant loop is directed to the low-pressure inlet of the compressor upon exiting the outlet of the first heat exchanger.

Abstract: The present disclosure provides high concentration injectable particle suspensions of therapeutic biologics that permit administration without the need for resuspension. In particular, the compositions disclosed herein are highly concentrated low volume injectable particle suspensions that do not require manual premixing or resuspension prior to administration.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes a first heat exchanger, a first region of a second heat exchanger, a third heat exchanger, a fourth heat exchanger, a compressor, a vapor generator, an accumulator, a first expansion valve, and a first three-way valve. The compressor includes a low-pressure inlet, a mid-pressure inlet, and an outlet. The vapor generator is positioned downstream of the outlet of the compressor and upstream of both the low-pressure inlet and the mid-pressure inlet. The accumulator is positioned immediately upstream of the compressor. The accumulator includes an inlet and an outlet. The first expansion valve is positioned upstream of the accumulator. The first expansion valve includes an inlet and an outlet. The first three-way valve is positioned immediately downstream of the first expansion valve and immediately upstream of the accumulator.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes a compressor, a first condenser, a vapor generator having a first region and a second region, a first expansion valve, a second expansion valve, and a first evaporator. A branching point is positioned between the first condenser and the vapor generator. The branching point diverts a portion of a first heat exchange fluid circulating through the refrigerant loop to the vapor generator. The first expansion valve is positioned between the branching point and the vapor generator. An outlet of the vapor generator is coupled to a mid-pressure inlet port of the compressor.

Abstract: Presented is a vehicle thermal system. The vehicle thermal system comprises a thermal loop and a controller. The thermal loop includes a compressor, condenser, vapor injector, internal heat exchanger, chiller, and bypass valve. The controller, during a dehumidification operation, opens an injector valve of the vapor injector such that the vapor injector injects vapor into the compressor, and opens the bypass valve such that fluid flow through the internal heat exchanger decreases.

Abstract: A system for adapting drilling of a borehole in a subterranean formation based on comparing a received cuttings weight to an expected cuttings weight. The system comprises a processor; a non-transitory memory; at least one display; and an application stored in the non-transitory memory that, when executed by the processor, determines the received cuttings weight based on data received from a cuttings storage unit (CSU); determines the expected cuttings weight based on a current borehole depth, on a drill bit geometry, and on a cuttings density value; and presents a representation of the received cuttings weight and a representation of the expected cuttings weight on the at least one display, whereby at least one parameter of drilling of the borehole is adapted based on comparing the representation of the received cuttings to the representation of the expected cuttings weight.

Abstract: A heat pump includes a refrigerant loop. The refrigerant loop includes an accumulator having an inlet and an outlet, a compressor, a first heat exchanger, and a first coupling point. The compressor includes a low-pressure inlet and an outlet. The low-pressure inlet is downstream of the outlet of the accumulator. The first heat exchanger includes an inlet and an outlet. The first coupling point is positioned immediately downstream of the outlet of the accumulator and immediately upstream of the low-pressure inlet of the compressor. The first coupling point is immediately downstream of the outlet of the first heat exchanger such that a first heat exchange fluid circulating through the refrigerant loop is directed to the low-pressure inlet of the compressor upon exiting the outlet of the first heat exchanger.