Abstract: A robotic cleaner includes a housing, a suction conduit with an opening, and a leading roller mounted in front of a brush roll. An inter-roller air passageway may be defined between the leading roller and the brush roll wherein the lower portion of the leading roller is exposed to a flow path to the suction conduit and an upper portion of the leading roller is outside of the flow path. Optionally, a combing unit includes a plurality of combing protrusions extending into the leading roller and having leading edges not aligned with a center of the leading roller. Optionally, a sealing strip is located along a rear side of the opening and along a portion of left and right sides of the opening. The underside may define side edge vacuum passageways extending from the sides of the housing partially between the leading roller and the sealing strip towards the opening.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: This disclosure provides compositions, pharmaceutical preparations, and methods relating to circular polyribonucleotides encoding an immunogen and a multimerization domain useful in the development and production of vaccines.

Abstract: Aspects of the disclosure relate to an environment analysis platform for air composition estimation. The environment analysis platform may receive a set of environment information corresponding to an environment from one or more environment information sources. The environment analysis platform may generate an estimated air composition using an environment analysis model. The environment analysis platform may generate a cumulative particle score based on the estimated air composition. The environment analysis platform may determine whether or not the cumulative particle score satisfies a criteria. The criteria may indicate whether the environment is a compliant environment or an outlier environment. The environment analysis platform may send one or more commands directing a user device to display a user interface based on the determination.

Abstract: Methods for manufacturing rotary target materials that allow a material to be cast in a melting zone of a casting vessel while the vessel is rotated such that a melting zone is below a casting zone. The vessel is sealed and the pressure inside the vessel is reduced and the exterior of the vessel is heated. The melting zone of the vessel is heated to a temperature that melts the material and releases any trapped gasses which can be pumped out using the vacuum pump. Once the melting zone and molten material have reached a specified temperature, outgassed, and the casting zone has reached a temperature to maximize adhesion and reduce voids and defects, the vessel is rotated until the melting zone is directly above the casting zone to transfer the material from the melting zone to the casting zone.

Abstract: A surface cleaning head with dual rotating agitators (e.g., a leading roller and a brush roll) may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The leading roller is generally positioned adjacent to and in advance of the opening of the suction conduit. The rotating brush roll may be located in the suction conduit with the leading roller located in front of and spaced from the brush roll, forming an inter-roller air passageway therebetween. The leading roller may provide a softer cleaning element than the brush roll and may also have an outside diameter that is less than the outside diameter of the brush roll. The surface cleaning head may also include debriding protrusions contacting the leading roller and/or a leading bumper that extends in front of the leading roller.

Abstract: A beverage system is provided. An adaptor assembly can be used with the beverage system and include a brew basket defining a cavity therein and having a fluid outlet. The assembly also includes a pod adapter and a filter adaptor receivable within the cavity in the brew basket. The pod adapter has at least one engagement feature arranged to be received within at least one corresponding slot in the brew basket. The filter adaptor includes a showerhead coupled to the filter body, the showerhead being arranged to receive fluid through an opening therein and to distribute fluid into the filter body. An internal storage cavity can be arranged within the housing of the beverage system for storing the adaptors. Additionally, a flow path cover can be positioned on the beverage system and configured to prevent unintentional water discharge from a brew chamber.

Abstract: A beverage system is provided. An adaptor assembly can be used with the beverage system and include a brew basket defining a cavity therein and having a fluid outlet. The assembly also includes a pod adapter and a filter adaptor receivable within the cavity in the brew basket. The pod adapter has at least one engagement feature arranged to be received within at least one corresponding slot in the brew basket. The filter adaptor includes a showerhead coupled to the filter body, the showerhead being arranged to receive fluid through an opening therein and to distribute fluid into the filter body. An internal storage cavity can be arranged within the housing of the beverage system for storing the adaptors. Additionally, a flow path cover can be positioned on the beverage system and configured to prevent unintentional water discharge from a brew chamber.

Abstract: A beverage system is provided. An adaptor assembly can be used with the beverage system and include a brew basket defining a cavity therein and having a fluid outlet. The assembly also includes a pod adapter and a filter adaptor receivable within the cavity in the brew basket. The pod adapter has at least one engagement feature arranged to be received within at least one corresponding slot in the brew basket. The filter adaptor includes a showerhead coupled to the filter body, the showerhead being arranged to receive fluid through an opening therein and to distribute fluid into the filter body. An internal storage cavity can be arranged within the housing of the beverage system for storing the adaptors. Additionally, a flow path cover can be positioned on the beverage system and configured to prevent unintentional water discharge from a brew chamber.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: A surface cleaning head with dual rotating agitators (e.g., a leading roller and a brush roll) may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The leading roller is generally positioned adjacent to and in advance of the opening of the suction conduit. The rotating brush roll may be located in the suction conduit with the leading roller located in front of and spaced from the brush roll, forming an inter-roller air passageway therebetween. The leading roller may provide a softer cleaning element than the brush roll and may also have an outside diameter that is less than the outside diameter of the brush roll. The surface cleaning head may also include debriding protrusions contacting the leading roller and/or a leading bumper that extends in front of the leading roller.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: A robotic cleaner includes a housing, a suction conduit with an opening, and a leading roller mounted in front of a brush roll. An inter-roller air passageway may be defined between the leading roller and the brush roll wherein the lower portion of the leading roller is exposed to a flow path to the suction conduit and an upper portion of the leading roller is outside of the flow path. Optionally, a combing unit includes a plurality of combing protrusions extending into the leading roller and having leading edges not aligned with a center of the leading roller. Optionally, a sealing strip is located along a rear side of the opening and along a portion of left and right sides of the opening. The underside may define side edge vacuum passageways extending from the sides of the housing partially between the leading roller and the sealing strip towards the opening.

Abstract: The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a therapeutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.

Abstract: Automated systems and methods for deployment of mounting tubs that support photovoltaic modules are provided in which a feeder assembly includes a screw thread assembly and a pivot arm. The screw thread assembly has at least one rotatable threaded component, and two such components in exemplary embodiments, positioned within the feeder assembly. The rotatable threaded component supports the stack of mounting tubs and rotates to separate the individual mounting tub from the stack of mounting tubs and lower the individual mounting tub onto the pivot arm. The pivot arm is configured to interact with an individual mounting tub and pivots to dispense the individual mounting tub onto a mounting surface. A sensor may be provided to detect the positions of the individual mounting tubs as they are moved, and a control system communicates with the sensor and the feeder assembly. The feeder assembly and a hopper holding the stack of mounting tubs may be mounted on an autonomous cart.

Abstract: Paver feeder assemblies, systems, and methods for use in mounting photovoltaic modules are provided which comprise a support structure and an elevator. The support structure is configured to support a plurality of pavers arranged in a stack. The elevator is configured to move the single paver from the support structure and to release the single paver into a mounting tub. The elevator may be a crane gantry configured to move in three axes. A restraining mechanism may be provided, which is configured to separate a single paver from the stack. The elevator may be a shelf assembly comprising one or more side restraints and one or more grippers configured to grasp a single paver and move from a start position adjacent to the support structure to lower the single paver to an end position directly above a floor of a mounting tub. The paver feeder assembly may be mounted on a mobile unit that is loaded with pavers at a staging area and moved to a dispensing area where mounting tubs are located.

Abstract: A robotic cleaner includes a housing, a suction conduit with an opening, and a leading roller mounted in front of a brush roll. An inter-roller air passageway may be defined between the leading roller and the brush roll wherein the lower portion of the leading roller is exposed to a flow path to the suction conduit and an upper portion of the leading roller is outside of the flow path. Optionally, a combing unit includes a plurality of combing protrusions extending into the leading roller and having leading edges not aligned with a center of the leading roller. Optionally, a sealing strip is located along a rear side of the opening and along a portion of left and right sides of the opening. The underside may define side edge vacuum passageways extending from the sides of the housing partially between the leading roller and the sealing strip towards the opening.

Abstract: Photovoltaic module feeder assemblies, systems and methods are provided which comprise two rotatable arms, a grabber bar, and at least two gripping pieces. Each arm has a proximal end and a distal end and a plurality of articulation points. The grabber bar is coupled to the distal end of each rotatable arm, and the gripping pieces are connected to each grabber bar. When the rotatable arms rotate to position the grabber bars in alignment with a photovoltaic module, the gripping pieces activate and grip or support the photovoltaic module. The rotatable arms maintain the short sides of the photovoltaic module in a horizontal position by utilizing one or more of the plurality of articulation points. The photovoltaic module feeder assembly may be coupled to a mobile unit having a conveyor and guide rails for moving and holding a pallet of photovoltaic modules. Disclosed methods may be controlled by software that can determine a just-in-time installation schedule.

Abstract: A beverage dispensing device and methods for dispensing beverages are provided. In one embodiment, the beverage dispensing device includes a housing, a carbonation assembly, a carriage assembly, and one or more flavorant containers. The beverage dispensing device can also include a controller with a UI to allow a user to customize aspects of a beverage. These customizable aspects can include fluid volume, carbonation level, flavorant type, and/or flavorant amount. Based on the customized aspects of the beverage, the beverage dispensing device can dispense an amount of carbonated or uncarbonated water, and can dispense a type and amount of flavorant. Illustrative embodiments of flavorant containers are also provided.