Abstract: A hearing prosthesis, comprising: a microphone; a sound processor; an external transmitter unit including a coil; an internal receiver unit including a coil; a stimulator unit, wherein the stimulator unit includes a control circuit, a voltage measurement component, a resistor and a signal generator, wherein the measurement circuit is configured to output a signal indicative of the voltage across the resistor; and a stimulating lead assembly array, wherein at least a portion of the hearing prosthesis is configured to apply an electrical signal to tissue inside a cochlea of a recipient, and at least a portion of the hearing prosthesis is configured to sense an electrical property inside of the cochlea that results from the applied electrical signal and the interaction of the applied electrical signal to the tissue.

Abstract: Aspects of the disclosure relate to an environment analysis platform for air composition estimation. The environment analysis platform may receive a set of environment information corresponding to an environment from one or more environment information sources. The environment analysis platform may generate an estimated air composition using an environment analysis model. The environment analysis platform may generate a cumulative particle score based on the estimated air composition. The environment analysis platform may determine whether or not the cumulative particle score satisfies a criteria. The criteria may indicate whether the environment is a compliant environment or an outlier environment. The environment analysis platform may send one or more commands directing a user device to display a user interface based on the determination.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: Aspects of the disclosure relate to an environment analysis platform for air composition estimation. The environment analysis platform may receive a set of environment information corresponding to an environment from one or more environment information sources. The environment analysis platform may generate an estimated air composition using an environment analysis model. The environment analysis platform may generate a cumulative particle score based on the estimated air composition. The environment analysis platform may determine whether or not the cumulative particle score satisfies a criteria. The criteria may indicate whether the environment is a compliant environment or an outlier environment. The environment analysis platform may send one or more commands directing a user device to display a user interface based on the determination.

Abstract: Methods for manufacturing rotary target materials that allow a material to be cast in a melting zone of a casting vessel while the vessel is rotated such that a melting zone is below a casting zone. The vessel is sealed and the pressure inside the vessel is reduced and the exterior of the vessel is heated. The melting zone of the vessel is heated to a temperature that melts the material and releases any trapped gasses which can be pumped out using the vacuum pump. Once the melting zone and molten material have reached a specified temperature, outgassed, and the casting zone has reached a temperature to maximize adhesion and reduce voids and defects, the vessel is rotated until the melting zone is directly above the casting zone to transfer the material from the melting zone to the casting zone.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a therapeutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.

Abstract: A hearing prosthesis, comprising: a microphone; a sound processor; an external transmitter unit including a coil; an internal receiver unit including a coil; a stimulator unit, wherein the stimulator unit includes a control circuit, a voltage measurement component, a resistor and a signal generator, wherein the measurement circuit is configured to output a signal indicative of the voltage across the resistor; and a stimulating lead assembly array, wherein at least a portion of the hearing prosthesis is configured to apply an electrical signal to tissue inside a cochlea of a recipient, and at least a portion of the hearing prosthesis is configured to sense an electrical property inside of the cochlea that results from the applied electrical signal and the interaction of the applied electrical signal to the tissue.

Abstract: A hearing prosthesis, comprising: a microphone; a sound processor; an external transmitter unit including a coil; an internal receiver unit including a coil; a stimulator unit, wherein the stimulator unit includes a control circuit, a voltage measurement component, a resistor and a signal generator, wherein the measurement circuit is configured to output a signal indicative of the voltage across the resistor; and a stimulating lead assembly array, wherein at least a portion of the hearing prosthesis is configured to apply an electrical signal to tissue inside a cochlea of a recipient, and at least a portion of the hearing prosthesis is configured to sense an electrical property inside of the cochlea that results from the applied electrical signal and the interaction of the applied electrical signal to the tissue.

Abstract: Methods for manufacturing rotary target materials that allows a material to be cast in a melting zone of a casting vessel while the vessel is rotated such that a melting zone is below a casting zone. The vessel is sealed and the pressure inside the vessel is reduced and the exterior of the vessel is heated. The melting zone of the vessel is heated to a temperature that melts the material and releases any trapped gasses which can be pumped out using the vacuum pump. Once the melting zone and molten material have reached a specified temperature, outgassed, and the casting zone has reached a temperature to maximize adhesion and reduce voids and defects, the vessel is rotated until the melting zone is directly above the casting zone to transfer the material from the melting zone to the casting zone.

Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: This invention, among other things, relates to CD19 binding agents and methods of using such CD binding agents for treating disease.

Abstract: A handheld wood thread cutting tool with an elongated shank formed with a planar surface and including a first end and a second end with a length substantially longer than its width. The first end has a first wood thread cutting edge aligned substantially in parallel relative to a first vertical plane perpendicular to the planar surface and passing through the length of the elongated shank from the first end to the second end. The second end has a second wood thread cutting edge aligned substantially parallel to a second vertical plane perpendicular to the planar surface and running through the width of the elongated shank from a first side wall to a second side wall. A ball handle is affixed between the first and the second end.

Abstract: A rectenna for high efficiency RF-to-DC wireless energy harvesting that includes an off-center-fed patch (OCFP) antenna and a rectifying circuit. The input impedance of the antenna may be tunable and directly conjugate matched to an impedance of the rectifying circuit over a wide range of frequencies and/or under different operating conditions. An impedance matching network required by rectenna systems may therefore be eliminated using the methods disclosed for the design and implementation of the OCFP rectenna. The OCFP rectenna offers consistently high RF-to-DC power conversion efficiency over a wide range of frequencies and under different operating conditions.

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: Aspects of the present invention are generally directed to impedance spectroscopy in an active implantable medical device (AIMD) comprising a component with one or more electrodes. In an embodiment, the AIMD applies a signal at a plurality of frequencies using one or more of the electrodes. Measurements are then obtained for the applied signal to determine impedance(s) at the applied frequencies of the tissue in which the electrodes are located.

Abstract: A handheld wood thread cutting tool with an elongated shank formed with a planar surface and including a first end and a second end with a length substantially longer than its width. The first end has a first wood thread cutting edge aligned substantially in parallel relative to a first vertical plane perpendicular to the planar surface and passing through the length of the elongated shank from the first end to the second end. The second end has a second wood thread cutting edge aligned substantially parallel to a second vertical plane perpendicular to the planar surface and running through the width of the elongated shank from a first side wall to a second side wall. A ball handle is affixed between the first and the second end.