Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Abstract: A hearing prosthesis, comprising: a microphone; a sound processor; an external transmitter unit including a coil; an internal receiver unit including a coil; a stimulator unit, wherein the stimulator unit includes a control circuit, a voltage measurement component, a resistor and a signal generator, wherein the measurement circuit is configured to output a signal indicative of the voltage across the resistor; and a stimulating lead assembly array, wherein at least a portion of the hearing prosthesis is configured to apply an electrical signal to tissue inside a cochlea of a recipient, and at least a portion of the hearing prosthesis is configured to sense an electrical property inside of the cochlea that results from the applied electrical signal and the interaction of the applied electrical signal to the tissue.

Abstract: A removable rack for holding and/or transporting kayaks with a vehicle such as a pick up, trailer, utility vehicle or flat bed truck. The rack comprises a frame which holds at least one kayaks in a pickup at a selected height and leaving storage room under rack frame. The rack also can be disassembled into a relatively small bundle of parts for easy storage and transport. The rack provides a dolly or hand truck including a frame with wheels and a handle means to maintain the desired spacing between the support surface and the kayak supported by the elevated platform. The hand truck assembly are configured to be easily moved onto an elevated platform, for example, the bed of a truck or an elevated floor such as a raised patio or deck floor. The transport device facilitates transportation of the kayak to a body of water.

Abstract: A rectenna for high efficiency RF-to-DC wireless energy harvesting that includes an off-center-fed dipole antenna and a rectifying circuit, wherein the rectifying circuit comprises at least one rectifying diode. The input impedance of the antenna may be directly conjugate matched to the impedance of the rectifying circuit over a wide range of frequencies and/or under different operating conditions. The impedance matching network required by a conventional rectenna system may therefore be eliminated using the methods disclosed for the design and implementation of the rectenna. The rectenna offers consistently high RF-to-DC power conversion efficiency over a wide range of frequencies and under different operating conditions. The rectenna may be connectible to a rectifying circuit utilizing different types of rectifying diodes.

Abstract: A rectenna for high efficiency RF-to-DC wireless energy harvesting that includes an off-center-fed dipole antenna and a rectifying circuit, wherein the rectifying circuit comprises at least one rectifying diode. The input impedance of the antenna may be directly conjugate matched to the impedance of the rectifying circuit over a wide range of frequencies and/or under different operating conditions. The impedance matching network required by a conventional rectenna system may therefore be eliminated using the methods disclosed for the design and implementation of the rectenna. The rectenna offers consistently high RF-to-DC power conversion efficiency over a wide range of frequencies and under different operating conditions. The rectenna may be connectible to a rectifying circuit utilizing different types of rectifying diodes.

Abstract: This invention relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

Abstract: A surface cleaning head includes dual rotating agitators (e.g., a leading roller and a brush roll) and a removable cover for covering a top of the agitators and allowing access to the agitators from a top of the surface cleaning head. The dual agitators may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The brush roll may be located in a brush roll chamber and at least partially in an opening to the suction conduit. The leading roller may be positioned adjacent to and in advance of the suction conduit opening such that the leading roller engages debris and moves the debris toward the brush roll and the opening. The leading roller may be removable from the housing and held in place by the removable cover. The cover may be coupled using isolated latching mechanisms.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: As disclosed, a hearing prosthesis that receives audio provided by an external device will also receive from the external device a control signal that indicates one or more characteristics of the audio, such as a specification of a dynamic range of the audio content, a specification of latency-sensitivity of the audio content, or various other characteristics of the audio. The hearing prosthesis then responds to receipt of the control signal by automatically configuring its sound processor in a manner based at least in part on the indicated one or more characteristics of the audio content, to help facilitate processing of the received audio.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: A surface cleaning head with dual rotating agitators (e.g., a leading roller and a brush roll) may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The leading roller is generally positioned adjacent to and in advance of the opening of the suction conduit. The rotating brush roll may be located in the suction conduit with the leading roller located in front of and spaced from the brush roll, forming an inter-roller air passageway therebetween. The leading roller may provide a softer cleaning element than the brush roll and may also have an outside diameter that is less than the outside diameter of the brush roll. The surface cleaning head may also include debriding protrusions contacting the leading roller and/or a leading bumper that extends in front of the leading roller.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a therapeutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.

Abstract: An implantable hearing prosthesis, comprising an integrated integrity system. The integrity system is configured to measure one or more electrical characteristics of at least one component of the prosthesis, to evaluate the integrity of the prosthesis based on the measurements, and to perform at least one diagnostic operation based on the evaluation.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: As disclosed, a hearing prosthesis that receives audio provided by an external device will also receive from the external device a control signal that indicates one or more characteristics of the audio, such as a specification of a dynamic range of the audio content, a specification of latency-sensitivity of the audio content, or various other characteristics of the audio. The hearing prosthesis then responds to receipt of the control signal by automatically configuring its sound processor in a manner based at least in part on the indicated one or more characteristics of the audio content, to help facilitate processing of the received audio.

Abstract: Release of attachment assemblies. Attachment assemblies including releasing mechanism, a trigger; and cables in mechanical communication with the releasing mechanism and with the trigger for operation of each releasing mechanism having such mechanical communication.

Abstract: This method of determining an intracochlea tissue impedance comprises using at least two stimulating electrodes to apply an electrical stimulus to intracochlea tissue. A voltage caused by the stimulus is measured between two measuring electrodes distinct from the stimulating electrodes. From the voltage a stimulus-response characteristic of tissue between the two measuring electrodes is determined This allows the tissue/electrode interface impedance and potential and the tissue impedance and potential to be uniquely determined. In turn, modiolus currents can be estimated in monopolar stimulation mode.

Abstract: This method of determining an intracochlea tissue impedance comprises using at least two stimulating electrodes to apply an electrical stimulus to intracochlea tissue. A voltage caused by the stimulus is measured between two measuring electrodes distinct from the stimulating electrodes. From the voltage a stimulus-response characteristic of tissue between the two measuring electrodes is determined. This allows the tissue/electrode interface impedance and potential and the tissue impedance and potential to be uniquely determined. In turn, modiolus currents can be estimated in monopolar stimulation mode. Also provided is automated initiation of re-mapping of the device when tissue characteristics change.