Abstract: The invention is directed to physiologically active compounds of general formula (I):— and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

Abstract: A hydrostatic transmission including a pump, a motor, and a center section provided with a conduit through which the pump and motor are in fluid communication and a valve. The pump, motor and center section are disposed in a housing having a plurality of walls which at least partially define a sump, the conduit being in fluid communication with the sump through the valve when the valve is open. A hydraulic disconnect mechanism is provided which includes a substantially rigid first portion, and a second portion operatively engaged with the first portion and being at least partially resilient. The valve is operably engaged with and opened by the second portion in response to the first portion being in an engaged position, and the valve is not operably engaged with the second portion when the first portion is in a disengaged position.

Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of ?-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

Abstract: This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; R1 represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms, or when Z1 represents a direct bond R1 may also represent a lower alkenyl or lower alkynyl group, or a formyl group; R2 represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, —SO2NR4R5, —NR4SO2R5, —NR4R5, —C(?O)R5, —C(?O)C(?O)R5, —C(?O)NR4R5, —C(?O)OR5, —O(C?O)NR4R5, or

Abstract: A hydrostatic transmission including a pump, a motor, and a center section provided with a conduit through which the pump and motor are in fluid communication and a valve. The pump, motor and center section are disposed in a housing having a plurality of walls which at least partially define a sump, the conduit being in fluid communication with the sump through the valve when the valve is open. A hydraulic disconnect mechanism is provided which includes a substantially rigid first portion, and a second portion operatively engaged with the first portion and being at least partially resilient. The valve is operably engaged with and opened by the second portion in response to the first portion being in an engaged position, and the valve is not operably engaged with the second portion when the first portion is in a disengaged position.

Abstract: A hydrostatic pump assembly having a casing which encloses a pumping mechanism, and including a housing, and an endcap attached to the housing. The endcap has at least one lateral exterior surface, and a first system fluid passage having a pair of system ports located in the endcap lateral exterior surface, and a second system fluid passage having a pair of system ports located in the endcap lateral exterior surface, each of the first and second system fluid passages being in fluid communication with the pumping mechanism. In one embodiment, the pair of system ports of the first system fluid passage are located opposite each other in the endcap lateral exterior surface. The pair of system ports of the second system fluid passage may also be located opposite each other in the endcap lateral exterior surface.

Abstract: An electroluminescent lamp or display comprises a first electrode on a substrate interdigitated with a second electrode on the same substrate. A layer of electroluminescent material is provided over the electrodes. The arrangement has the advantage that light from the electroluminescent material does not need to pass through either of the electrodes. The substrate may be a printed circuit board. In an alternative embodiment the second electrode is provided over the layer of electroluminescent material and gaps are provided in the electrode for the emission for light. The electroluminescent lamps may be used to form a seven-segment display.

Abstract: A hydrostatic transmission including a fluid motor in communication with a variable displacement fluid pump having a first displacement rate and a second greater displacement rate, a pump block having at least one fluid conduit through which fluid flows from the pump to the motor, an external fluid sump, a cylindrical pintle fixed to the block having a first bleed hole and a second bleed hole in communication with the first bleed hole, and a ring in sliding engagement with the pintle and having a slot in selective communication with the second bleed hole. The conduit and the sump are in communication through the bleed holes and the slot at the first displacement rate, and the fluid conduit and the sump are out of fluid communication at the second displacement rate.

Abstract: A reversible implement including an engine, an axle driven by the engine, a pair of ground engaging wheels with a wheel located at each axle end, a pair of input hubs rotatably fixed to the axle, a pair of wheel hubs with a wheel hub located at each axle end and attached to a ground engaging wheel, and a wrap spring surrounding a portion of each input hub and each wheel hub. Each wrap spring has a relaxed state, wherein the wrap spring is in one of a first position in which the wrap spring is disengaged from the wheel hub, and the input and wheel hubs are not rotatively coupled and a second position in which the wrap spring is engaged with the wheel hub, and the input and wheel hubs are rotatively coupled, and a contracted state, wherein the wrap spring is in the other position.

Abstract: A modular, self-contained, bi-directional wheel clutch unit selectively attachable and detachable as a unit to and from an axle, the unit including a rotatable wheel-driving hub including a casing portion, a clutch cage disposed in the casing portion and surrounded thereby and which has a plurality of circumferentially-distributed openings, a rotatably driven cam element disposed in the casing portion and surrounded by the clutch cage and which has a plurality of discrete surfaces thereon, and a plurality of rollers rotatably disposed within the casing portion and within the clutch cage openings. The rollers are located between the casing portion and the cam element discrete surfaces and have an engaged position wherein the cam element and the hub are in binding engagement through the rollers and the hub is rotatably driven by the cam element, and a disengaged position wherein the hub is freely rotatable relative to the cam element.

Abstract: A routing node for translating and re-directing Signaling System 7 (SS7) messages associated with ported subscribers in a communications network is disclosed. Re-direction or re-routing of signaling message packets is accomplished without the need for explicit local number portability (LNP) type triggers or queries, and as such the routing node of the present invention is considered to implement a triggerless LNP routing solution. Upon entering the routing node, SS7 ISDN User Part (ISUP) type signaling messages that require LNP translation service are encapsulated in an SS7 Signaling Connection Control Part (SCCP) message packet and internally routed within the switch to an LNP translation subsystem. The LNP translation subsystem can be integrated within the routing node or a portion of the LNP translation subsystem can be located on an external database server platform. LNP translation involves the lookup of a called party address in an LNP database, and the return of a Location Routing Number (LRN).

Abstract: A method and system for terrain aided navigation which provide more precise and more accurate position, velocity, altitude, and attitude for an air vehicle. The present method is a continuous, active, all-weather, day/night, self-contained vehicle system used for terminal and en route navigation. The present method utilizes on-vehicle sensing elements which require no external stimulation, eliminating dependence on external ground and space-based navigation aides. The present method also provides a drift-free solution. The present method is more difficult to detect (sense) and more difficult to disrupt.

Abstract: A walk-behind self-propelled implement, such as a snow thrower or lawnmower, for example, is provided. The implement includes first and second transmission modules associated with a common single axle to which a pair of drive wheels is attached. The first and second transmission modules are operable exclusively with respect to one another to drive the axle and the wheels in a forward and reverse direction, respectively. A control member mounted to the handle of the implement includes a forward bail member pivotable to rotate the control member in a first direction to urge the wheel to rotate in a forward direction, and a reverse bail member pivotable to rotate the control member in a second direction opposite the first direction to urge the wheel to rotate in a reverse direction.

Abstract: A modular, self-contained, bi-directional wheel clutch unit selectively attachable and detachable as a unit to and from an axle, the unit including a rotatable wheel-driving hub including a casing portion, a clutch cage disposed in the casing portion and surrounded thereby and which has a plurality of circumferentially-distributed openings, a rotatably driven cam element disposed in the casing portion and surrounded by the clutch cage and which has a plurality of discrete surfaces thereon, and a plurality of rollers rotatably disposed within the casing portion and within the clutch cage openings. The rollers are located between the casing portion and the cam element discrete surfaces and have an engaged position wherein the cam element and the hub are in binding engagement through the rollers and the hub is rotatably driven by the cam element, and a disengaged position wherein the hub is freely rotatable relative to the cam element.

Abstract: A reversible implement including an engine, an axle driven by the engine, a pair of ground engaging wheels with a wheel located at each axle end, a pair of input hubs rotatably fixed to the axle, a pair of wheel hubs with a wheel hub located at each axle end and attached to a ground engaging wheel, and a wrap spring surrounding a portion of each input hub and each wheel hub. Each wrap spring has a relaxed state, wherein the wrap spring is in one of a first position in which the wrap spring is disengaged from the wheel hub, and the input and wheel hubs are not rotatively coupled and a second position in which the wrap spring is engaged with the wheel hub, and the input and wheel hubs are rotatively coupled, and a contracted state, wherein the wrap spring is in the other position.

Abstract: A portable humidifier including a housing defining an air inlet, an air outlet, and an air flow path therebetween; a retainer disposed in the housing; and an air permeable, liquid absorbent cartridge element replaceably retained by the retainer and having a handle to facilitate removal from the housing. Also included is a blower disposed in the housing and activatable to produce air flow through the air flow path and cartridge element and a liquid supply for supplying liquid to the cartridge element.

Abstract: The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.