Abstract: A medical device, configured for insertion into a body, may include an elongate member extending from a proximal end to a distal end, where the distal end may be configured to be positioned inside the body. The medical device may also include an imaging device positioned at the distal end. The medical device may further include a plurality of light sources positioned at the distal end, wherein a characteristic of light delivered through a first light source may be controlled independent of the characteristic of light delivered through a second light source.

Abstract: A wearable drug delivery device includes a housing, a needle assembly at least partially disposed in the housing, and a drive assembly at least partially disposed in the housing and coupled to the needle assembly. The needle assembly includes a needle or cannula and a sterile barrier disposed proximal to the needle or cannula in a first configuration where the sterile barrier is intact. The drive assembly includes a container that contains a medicament to be administered, a first plunger disposed in the container, and a drive mechanism that forces the first plunger to urge the medicament through the container. Upon engaging the drive mechanism, the needle or cannula and the sterile barrier move relative to each other from the first configuration to a second configuration where the needle or cannula breaks the sterile barrier, thereby allowing the medicament to be administered via the needle or cannula.

Abstract: According to one aspect, a visualization device may include an image sensor, a lens for focusing light onto the image sensor, a first end, a second end opposite the first end, a lateral wall surface extending between the first end and the second end, and a coating on the lateral wall surface. The coating may include at least one of an electrically-insulating layer and a light-blocking layer, and may be deposited on the lateral wall surface using, for example, physical vapor deposition (PVD).

Abstract: Host specific containerized application configuration generation is disclosed. For example, first and second image files are stored on a first memory. Second and third memories are associated with a first host node. A request to generate a first configuration file associated with a plurality of isolated guests is received, launching a first short-lived guest of the plurality of isolated guests on the second memory. A configuration management application executes on the first short-lived guest, generating and saving the first configuration file to the third memory. The first short-lived guest is terminated. A first service guest of the plurality of isolated guests is launched on the second memory. A first service configured with the first configuration file executes on the first service guest. A second service guest of the plurality of isolated guests is launched on the second memory executing a second service configured with the first configuration file.

Abstract: An adaptor includes a body defining a longitudinal axis, and a transverse axis that is normal to the longitudinal axis. The body also has a leading portion defining a lock receiving recess extending transversely at least partially through the leading portion. The leading portion defines at least one linear portion in the lock receiving recess that is configured to engage the power locking device.

Abstract: A method, system, and apparatus are provided for improving accuracy of sensor readings reflecting measurements of at least one constituent in an engine exhaust. The sensor measurement is corrected or compensated for by applying to a gain correction factor to the reported sensor measurement. The gain correction factor is developed by determination of prior test sensor readings correlated with discrete sensor age levels, and with constituent concentrations to which those test sensors are exposed. By applying the determined gain correction factor to change the sensor's reported measurements, bias may be reduced and a more accurate measure of actual constituent levels is provided.

Abstract: Compositions and a process for consolidating sand, proppant and other suspended particles present in a subterranean reservoir using an aqueous emulsion particle consolidation system. Surfactants with cloud points below the reservoir temperature are used to make a low viscosity aqueous external emulsion system with resin and curing agent as the internal phase. As the surfactant reaches its cloud point, it loses its emulsification ability and release the resin and curing agent to consolidate the sand. The aqueous phase of the system then functions as spacer to maintain the permeability needed for oil and gas production without additional post flush needed.

Abstract: The present disclosure provides engineered Class 2 CRISPR-Cas-associated discontinuous first-stem nucleic-acid targeting nucleic acids, nucleoprotein complexes comprising these nucleic acids, and compositions thereof. Nucleic acid sequences encoding the Class 2 CRISPR-Cas-associated discontinuous first-stem nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. Also, methods are disclosed for making and using the Class 2 CRISPR-Cas-associated discontinuous first-stem nucleic-acid targeting nucleic acids, nucleoprotein complexes comprising such nucleic acids, and compositions thereof.

Abstract: A new CRISPR-associated (Cas) protein, termed “CasM,” is described, as well as polynucleotides encoding the same and methods of using CasM for site-specific genome engineering. CasM proteins are capable of targeting and cleaving single-stranded RNA.

Abstract: The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the engineered cross-type-nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. Also, methods are disclosed for making and using the engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof.

Abstract: The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of use involving such polynucleotides and DNA-guided CRISPR systems.

Abstract: A peripheral, such as a cooling fan or LED strip, is illuminated with addressable LEDs, which allow interactive control of the LEDs from a connected controller to create variable lighting effects. The fan can receive power and control signals from a controller, such as a motherboard and associated microprocessor within a host electronic device. The controller output may be based upon event data received from a host electronic device, such as system or application information relayed by a driver installed in a personal computer. The lighting can, amongst other things, convey status of temperature, load, and/or access to components of a personal computer. The fan may also indicate, e.g., queued email or instant messages, by utilizing the LEDs to display associated lighting and effects.

Abstract: Various embodiments include devices and methods for controlling a robotic vehicle. Each electronic speed controller (ESC) of the robotic vehicle may receive open loop flight control information from a flight controller or another processing device of the robotic vehicle. In some embodiments, each ESC may store the provided open loop flight control information in a memory. In response to detecting a loss of control signals from the flight controller, each ESC may access the stored open loop flight control information and perform control of a motor associated with each ESC based on the open loop flight control information. The open loop flight control information may be a sequence of motor control instructions to be performed over a period of time, or parameterized information or vehicle state information that enables each ESC to generate a sequence of motor control instructions.

Abstract: Systems and methods to visualize a registration utilize a visual aid, displayed in connection with an image, which is deformed according to the registration. A selected amount of transformation based on the registration can be applied to the image and the visual aid to generate a visualization of movement of respective portions of the image from an original state to a final state.

Abstract: Various embodiments relate to a thermal management system for an electronic device, such as an augmented reality or virtual reality device. The thermal management system can comprise an active cooling mechanism in various embodiments to dynamically or actively cool components of the device, for example, by adjust fan speeds of a fan assembly. In some embodiments, a hardware shutdown mechanism can be provided to shut down the device if software-based thermal management devices are inoperable. In some embodiments, the air flow into and/or within the electronic device can be adjusted to cool various components of the device.

Abstract: A method of forming a composite component comprising: forming a mandrel by additive manufacturing, the mandrel defining a shape for the component; providing a composite material around the mandrel to form a body of the component; curing the component body to produce the component, the mandrel forming a part of the component.

Abstract: The present invention relates to novel compounds and their use as fragrance materials.

Abstract: The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of use involving such polynucleotides and DNA-guided CRISPR systems.

Abstract: Methods, systems, and devices for debris permutation are described. A robotic device may identify a cleaning trigger for a first surface region (e.g., a cleaning schedule, a notification from a remote device). The robotic device may activate one or more rotors o based at least in part on the surface cleaning trigger and move to an aerial position proximal to (e.g., above, diagonal to) the first surface region using the one or more rotors. The device may displace debris from the first surface region to a second surface region using a pressurized air stream.

Abstract: Methods, systems, and devices for robotic navigation are described. A robotic device such as a robotic vacuum or a robotic assistant may navigate a first surface. In some cases, navigating the first surface may include removing debris from the first surface. The robotic device may identify a location of a track that connects the first surface to a second surface that is vertically displaced from the first surface. The robotic device may engage the track based at least in part on the identified location. The robotic device may ascend to the second surface by activating an actuator and navigate the second surface (e.g., may remove debris from the second surface, may map the second surface, etc.).