Abstract: A drug delivery device includes a housing releasably coupled with a patient, a pressure chamber disposed in the housing and including a vent, a container at least partially disposed in the pressure chamber for storing a drug connectable in fluid communication with a fluid conduit, an activation mechanism, and a relief mechanism. The activation mechanism releases a pressurized drive fluid into the pressure chamber for expelling the drug from the container into the fluid conduit. The relief mechanism is operably coupled to the fluid conduit and is adapted to open the vent to release the drive fluid from the pressure chamber in response to a predetermined condition.

Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.

Abstract: A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.

Abstract: An adaptor includes a body defining a longitudinal axis, and a transverse axis that is normal to the longitudinal axis. The body also has a leading portion defining a lock receiving recess extending transversely at least partially through the leading portion. The leading portion defines at least one linear portion in the lock receiving recess that is configured to engage the power locking device.

Abstract: A method includes receiving an execute packet that includes a first instruction and a second instruction and executing the first instruction and the second instruction using a pipeline. Executing the first and second instructions includes storing a result of the first instruction in a holding register; determining whether an event that interrupts execution of the execute packet occurs prior to completion of the executing of the second instruction; and based on the event not occurring, committing the result of the first instruction after completion of the executing of the second instruction.

Abstract: A method and apparatus for estimating a step length of a user are disclosed. The method involves obtaining inertial data generated by an inertial sensor, extracting orthogonal motion components a plurality of directions, and estimating, based on the orthogonal motion components for each direction, a respective parameter that is indicative of energy expenditure by the user in the corresponding direction. The step length is then estimated, based on each estimated parameter indicating energy expenditure by the user, a corresponding step length.

Abstract: Various embodiments include methods and vehicles, such as an autonomous vehicle, a semi-autonomous vehicle, etc., for collaboratively directing one or more headlights among vehicles traveling in a platoon. Various aspects may include transmitting, by a first vehicle processor of a first vehicle traveling in the platoon, a collaborative lighting plan to a second vehicle traveling in the platoon, wherein the collaborative lighting plan may direct the second vehicle to direct one or more headlights of the second vehicle in a direction other than a direction of travel of the platoon. The first vehicle processor may then direct one or more the headlights of the first vehicle in accordance with the collaborative lighting plan.

Abstract: Methods, devices and systems enable controlling an autonomous vehicle by identifying vehicles that are within a threshold distance of the autonomous vehicle, determining an autonomous capability metric of each of the identified vehicles, and adjusting a driving parameter of the autonomous vehicle based on the determined autonomous capability metric of each of the identified vehicles. Adjusting a driving parameter may include adjusting one or more of a minimum separation distance, a minimum following distance, a speed parameter, or an acceleration rate parameter.

Abstract: A new CRISPR-associated (Cas) protein, termed “CasM,” is described, as well as polynucleotides encoding the same and methods of using CasM for site-specific genome engineering. CasM proteins are capable of targeting and cleaving single-stranded RNA.

Abstract: A medical device, configured for insertion into a body, may include an elongate member extending from a proximal end to a distal end, where the distal end may be configured to be positioned inside the body. The medical device may also include an imaging device positioned at the distal end. The medical device may further include a plurality of light sources positioned at the distal end, wherein a characteristic of light delivered through a first light source may be controlled independent of the characteristic of light delivered through a second light source.

Abstract: Host specific containerized application configuration generation is disclosed. For example, first and second image files are stored on a first memory. Second and third memories are associated with a first host node. A request to generate a first configuration file associated with a plurality of isolated guests is received, launching a first short-lived guest of the plurality of isolated guests on the second memory. A configuration management application executes on the first short-lived guest, generating and saving the first configuration file to the third memory. The first short-lived guest is terminated. A first service guest of the plurality of isolated guests is launched on the second memory. A first service configured with the first configuration file executes on the first service guest. A second service guest of the plurality of isolated guests is launched on the second memory executing a second service configured with the first configuration file.

Abstract: Methods, devices and systems enable controlling an autonomous vehicle by identifying vehicles that are within a threshold distance of the autonomous vehicle, determining an autonomous capability metric of each of the identified vehicles, and adjusting a driving parameter of the autonomous vehicle based on the determined autonomous capability metric of each of the identified vehicles. Embodiments may further include determining, based on the determined ACMs, whether one or more identified vehicles would provide an operational advantage to the autonomous vehicle in a cooperative driving engagement, and initiating a cooperative driving engagement with the one or more identified vehicles in response to determining that the one or more identified vehicles would provide an operational advantage to the autonomous vehicle in a cooperative driving engagement.

Abstract: Various embodiments include methods and vehicles, such as an autonomous vehicle, a semi-autonomous vehicle, etc., for collaboratively directing one or more headlights by two or more vehicles. Various aspects may include receiving, by a first vehicle processor, a first vehicle collaborative lighting message from a second vehicle, in which the first vehicle collaborative lighting message requests that the first vehicle direct one or more headlights of the first vehicle to illuminate a target area of uncertainty that is disposed, relative to the first vehicle, in a direction other than a direction of travel of the first vehicle. The first vehicle processor may direct one or more the headlights of the first vehicle to illuminate the target area in accordance with the first vehicle collaborative lighting message.

Abstract: An integrated circuit comprising instruction processing circuitry for processing a plurality of program instructions and instruction prediction circuitry. The instruction prediction circuitry comprises circuitry for detecting successive occurrences of a same program loop sequence of program instructions. The instruction prediction circuitry also comprises circuitry for predicting a number of iterations of the same program loop sequence of program instructions, in response to detecting, by the circuitry for detecting, that a second occurrence of the same program loop sequence of program instructions comprises a same number of iterations as a first occurrence of the same program loop sequence of program instructions.

Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.

Abstract: A system and method for monitoring analog front-end (AFE) circuitry of an inductive position sensor. A redundant AFE channel is provided and alternatively utilized with a sine AFE channel or a cosine AFE channel of the AFE circuitry to obtain a voltage difference that may result in a detection angle error at the electronic control unit (ECU) of the inductive position sensor.

Abstract: An integrated circuit comprising instruction processing circuitry for processing a plurality of program instructions and instruction prediction circuitry. The instruction prediction circuitry comprises circuitry for detecting successive occurrences of a same program loop sequence of program instructions. The instruction prediction circuitry also comprises circuitry for predicting a number of iterations of the same program loop sequence of program instructions, in response to detecting, by the circuitry for detecting, that a second occurrence of the same program loop sequence of program instructions comprises a same number of iterations as a first occurrence of the same program loop sequence of program instructions.

Abstract: A new CRISPR-associated (Cas) protein, termed “CasM,” is described, as well as polynucleotides encoding the same and methods of using CasM for site-specific genome engineering. CasM proteins are capable of targeting and cleaving single-stranded RNA.

Abstract: A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, and a flow rate monitor. The delivery container further includes inlet and outlet ports and is constructed from a resilient material that exerts an urging force on the drug to expel the drug from the outlet port. The supply line is operably coupled to the outlet port to deliver the drug to a user. The flow rate monitor is operably coupled to at least one of the delivery container or the supply line and includes a digital controller, a fluid valve operably coupled to the digital controller, and a diaphragm assembly in fluid communication with the fluid valve and operably coupled to the digital controller. The fluid valve, the diaphragm assembly, and the digital controller cooperate to regulate a flow rate of the drug.