Abstract: Methods and systems using model based and iterative calculations of mass flow throughout an internal combustion engine system. A secondary air injection valve is provided to selectively allow intake air to pass to the exhaust side of the engine system to aid in exothermic reaction with exhaust gasses exiting the engine for various purposes. The iterative calculations of mass flow include estimation of the mass flow through the secondary air injection valve.

Abstract: The present disclosure relates to pharmaceutical compositions comprising Compound I, or a pharmaceutically acceptable salt thereof, as the active substance. The pharmaceutical compositions are suitable for use in immediate release pharmaceutical formulations. The pharmaceutical formulations are suitable for use in the treatment of medical conditions in which treatment with agonists of CB1/CB2 receptors are beneficial.

Abstract: Methods and systems for fault identification and mitigation in an engine system. A state observer obtains current state information from the engine system, and a feature calculator uses data obtained from the state observer to calculate one or more feature indicators, which are monitored by a health estimator for the occurrence of a change using one or more change probability models. When the health estimator identifies a change, a fault isolator determines a component of the engine system that is subject to fault or health deterioration.

Abstract: Methods and systems using model based and iterative calculations of mass flow throughout an internal combustion engine system. A secondary air injection valve is provided to selectively allow intake air to pass to the exhaust side of the engine system to aid in exothermic reaction with exhaust gasses exiting the engine for various purposes. The iterative calculations of mass flow include estimation of the mass flow through the secondary air injection valve.

Abstract: Methods and systems for fault identification and mitigation in an engine system. A state observer obtains current state information from the engine system, and a feature calculator uses data obtained from the state observer to calculate one or more feature indicators, which are monitored by a health estimator for the occurrence of a change using one or more change probability models. When the health estimator identifies a change, a fault isolator determines a component of the engine system that is subject to fault or health deterioration.

Abstract: A system for coordinated control of an engine and associated components over various engine-modes of operation. The system may include an engine, one or more components controllable to adjust operation of the diesel engine, and a system controller. The system controller may be connected to the engine and the one or more components. The system controller may include a supervisory controller and one or more component controllers. The supervisory controller may receive system control variable set points and coordinate component control variable set points for the components to achieve the system control variable set points. The component controllers may control operation of the components to achieve the control variable set points for the components by setting manipulated variable set points for the components based on the component control variable set points and a model based non-linear dynamic inversion.

Abstract: Methods and systems for calculating a plurality of aging factors in a system operating an engine. The calculated aging factors may include one or more of fuel injector drift, exhaust gas recirculation valve obstruction, and mass air flow sensor bias. Mass flow throughout the system, and pressures and temperatures within the system, are observed in an approach that relies on mass preservation concepts to estimate fuel injector drift, exhaust gas recirculation valve obstruction, and mass air flow sensor bias.

Abstract: The present invention relates to formulations comprising a compound of Formula (1) (6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine) which is an inhibitor of Aurora kinase enzyme activity and FMS-like tyrosine kinase 3 (FLT3) activity, and a non-ionic surfactant. The present invention also relates to processes for the preparation of the formulations of the compound, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Aurora kinase and/or FLT3 activity is implicated.

Abstract: Methods and systems for fault identification and mitigation in an engine system. A state observer obtains current state information from the engine system, and a feature calculator uses data obtained from the state observer to calculate one or more feature indicators, which are monitored by a health estimator for the occurrence of a change using one or more change probability models. When the health estimator identifies a change, a fault isolator determines a component of the engine system that is subject to fault or health deterioration.

Abstract: Methods and systems for calculating a plurality of aging factors in a system operating an engine. The calculated aging factors may include one or more of fuel injector drift, exhaust gas recirculation valve obstruction, and mass air flow sensor bias. Mass flow throughout the system, and pressures and temperatures within the system, are observed in an approach that relies on mass preservation concepts to estimate fuel injector drift, exhaust gas recirculation valve obstruction, and mass air flow sensor bias.

Abstract: A system for coordinated control of an engine and associated components over various engine-modes of operation. The system may include an engine, one or more components controllable to adjust operation of the diesel engine, and a system controller. The system controller may be connected to the engine and the one or more components. The system controller may include a supervisory controller and one or more component controllers. The supervisory controller may receive system control variable set points and coordinate component control variable set points for the components to achieve the system control variable set points. The component controllers may control operation of the components to achieve the control variable set points for the components by setting manipulated variable set points for the components based on the component control variable set points and a model based non-linear dynamic inversion.

Abstract: Methods and systems for fault mitigation in an engine system. For ordinary operation, a set of control signals are generated after calculating airflows within the engine system using a set of flow models linked to components of the engine system, while underweighting or omitting an output of a sensor in the engine system. When a fault is identified, the set of flow models is analyzed differently by underweighting or omitting one or more flow models in favor of using the sensor output. By so doing, the engine system can continue to be operated without triggering an on-board diagnostic alert requiring cessation of operation.

Abstract: Methods and systems for calculating a plurality of aging factors in a system operating an engine. The calculated aging factors may include one or more of fuel injector drift, exhaust gas recirculation valve obstruction, and mass air flow sensor bias. Mass flow throughout the system, and pressures and temperatures within the system, are observed in an approach that relies on mass preservation concepts to estimate drift, obstruction and bias estimates.

Abstract: A system for coordinated control of an engine and associated components over various engine-modes of operation. The system may include an engine, one or more components controllable to adjust operation of the diesel engine, and a system controller. The system controller may be connected to the engine and the one or more components. The system controller may include a supervisory controller and one or more component controllers. The supervisory controller may receive system control variable set points and coordinate component control variable set points for the components to achieve the system control variable set points. The component controllers may control operation of the components to achieve the control variable set points for the components by setting manipulated variable set points for the components based on the component control variable set points and a model based non-linear dynamic inversion.

Abstract: Methods and systems for calculating a plurality of aging factors in a system operating an engine. The calculated aging factors may include one or more of fuel injector drift, exhaust gas recirculation valve obstruction, and mass air flow sensor bias. Mass flow throughout the system, and pressures and temperatures within the system, are observed in an approach that relies on mass preservation concepts to estimate drift, obstruction and bias estimates.

Abstract: A system for coordinated control of an engine and associated components over various engine-modes of operation. The system may include an engine (e.g., a diesel engine), one or more components controllable to adjust operation of the diesel engine, and a system controller. The system controller may be connected to the engine and the one or more components. The system controller may include a supervisory controller and one or more component controllers. The supervisory controller may receive system control variable set points and coordinate component control variable set points for the components to achieve the system control variable set points. The component controllers may control operation of the components to achieve the control variable set points for the components by setting manipulated variable set points for the components based on the component control variable set points and a model based non-linear dynamic inversion.

Abstract: The present invention relates to thiocarbamate derivatives of Formula (I) which are useful as A2A adenosine receptor (A2AR) inhibitors Especially, the present invention relates to a pharmaceutical composition comprising an A2A inhibitor of Formula (I) and a lipid carrier such as lauroyl macrogol-32 glycerides, D-?-tocopherol-polyethylene glycol-1000 succinate or a mixture thereof. The pharmaceutical composition of the invention is particularly useful for oral dosing in the treatment of cancers. The present invention also relates to a combination comprising an A2A receptor inhibitor of Formula (I) and an anticancer agent. The anticancer agent is for example an immunotherapeutic agent, such as a checkpoint inhibitor. The invention further relates to a pharmaceutical composition and a kit of parts comprising such combination. Additionally, the combination of the invention is particularly useful for the treatment and/or prevention of cancers.

Abstract: Sepsis remains a leading cause of morbidity and mortality in neonates worldwide. There is also clinically a low threshold for suspicion of infection in neonates, in particular as presentation varies greatly from very subtle to catastrophic collapse. The lack of reliably sensitive tests and the potential life-threatening consequences of delayed treatment of infection results in the widespread use of empirical antibiotics exposing many infants without infection to broad-spectrum antibiotics. The present invention provides a series of patient-invariant biomarkers for screening neonates and other subjects for infection that predicts bacterial infection with high accuracy; and is further shown to have predictive value in identifying infection in suspected cases with blood-culture negative tests.

Abstract: A computer-implemented user interface method includes displaying on a touch screen a portion of a large scale graphical space that is at least multiples larger than the device display, receiving from a user of the device an input to pan within the graphical space, automatically generating a pop up graphical panning control in response to receiving the user input, and receiving a user input to the panning control and providing panning in the graphical space, wherein movement of the panning control in a single selection is able to pan the display across a substantial portion of the large scale graphical space.

Abstract: Golf training aid for improving a golfer's golf swing, insertable into a grip end of a golf club. The aid having a rod slidably connected to the grip end of the golf club, with the first end and a portion of the rod received within the hollow shaft of the golf club. A training element is connected to the second end of the rod and disposed outwardly beyond the grip end of the shaft of the golf club. The rod is slidably moveable from a retracted position to an extended position during a golf swing via gravity. In the retracted position, the training element is located adjacent the grip end of the golf club and a portion of the rod is received within the shaft. In the extended position, the rod is extended outwardly and the training element is spaced apart from the grip end of the golf club.