Patents by Inventor Paul E. Ashworth

Paul E. Ashworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210121290
    Abstract: At least a portion of sheet materials for use in medical devices is formed from polymeric materials. The sheet materials may be partially coated or fully coated with one or more additional layers of a polymer. The sheet materials may be used for the leaflets and/or cuffs of prosthetic heart valves and as a component of other medical devices.
    Type: Application
    Filed: June 11, 2020
    Publication date: April 29, 2021
    Applicant: Abbott Laboratories
    Inventors: Yousef F. Alkhatib, Jay Reimer, Paul E. Ashworth, Keith T. High
  • Publication number: 20210045868
    Abstract: A stabilized fabric composed of a mesh or a woven fabric is disclosed as are methods of their manufacture, the manufacture of medical devices made using a stabilized fibers and stabilized medical devices are all disclosed. Fabrics can be stabilized by several techniques including: using mechanical, chemical and/or energetic fasteners at warp and weft intersections in the weave; by using various weaving techniques and fibers. Meshes can be stabilized when properly dimensioned and arranged junctions and struts of the necessary properties are used. All of these stabilized fabrics can be made of synthetic polymer materials such as ultrahigh molecular weight PE or PP and expanded PTFE.
    Type: Application
    Filed: September 30, 2020
    Publication date: February 18, 2021
    Applicant: Abbott Laboratories
    Inventors: Jay Reimer, Paul E. Ashworth
  • Publication number: 20200323630
    Abstract: At least a portion of fabrics for use in medical devices is formed from polymeric materials. The fabrics may be uncoated, partially coated or fully coated with one or more layers of a polymer. The fabrics may be used for the leaflets and/or cuffs of prosthetic heart valves and as a component of other medical devices.
    Type: Application
    Filed: June 11, 2020
    Publication date: October 15, 2020
    Applicant: Abbott Laboratories
    Inventors: Yousef F. Alkhatib, Jay Reimer, Paul E. Ashworth, Keith T. High, Richard Kaleta, Ryan Finn
  • Patent number: 10788490
    Abstract: Methods of preparing a solid reference material so as to elicit a positive control response when tested for in-vitro complement activation include providing biological tissue; treating the tissue with an aqueous cellulose solution for a time sufficient to allow fluid in the tissue to be replaced by the aqueous cellulose solution; drying the cellulose-treated tissue by a vacuum-drying process or a lyophilization process to form dried tissue; and storing the dried tissue in a dry, ambient environment. The tissue prepared by these methods and its use in an in-vitro complement assay and diagnostic kit are also described.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: September 29, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Paul E. Ashworth
  • Patent number: 10722613
    Abstract: Methods of preparing calcification-resistant bioprosthetic tissue include providing fresh biological tissue, cross-linking the tissue, treating the cross-linked tissue with an alcohol for a time sufficient to allow the alcohol to be diffused into the tissue, and treating the alcohol-treated fixed tissue with a polyol for a time sufficient to allow fluid in the tissue to be replaced by the polyol. The methods may include sterilizing the cross-linked tissue in a solution including propylene oxide or peracetic acid either before or after the alcohol treatment step; or drying the alcohol/polyol-treated, cross-linked tissue, sterilizing the dried tissue by exposure to ethylene oxide or peracetic acid, and storing the sterilized tissue in a dry, ambient environment. The treated tissue may be a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: July 28, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Paul E. Ashworth, Chad Joshua Green, Jay Reimer, Katherine A. Ahmann, David A. Panus
  • Publication number: 20200188098
    Abstract: At least a portion of fabrics for use in medical devices is formed from polymeric materials. The fabrics may be uncoated, partially coated or fully coated with one or more layers of a polymer. The fabrics may be used for the leaflets and/or cuffs of prosthetic heart valves and as a component of other medical devices.
    Type: Application
    Filed: December 13, 2019
    Publication date: June 18, 2020
    Applicant: Abbott Laboratories
    Inventors: Yousef F. Alkhatib, Jay Reimer, Paul E. Ashworth, Keith T. High, Richard Kaleta, Ryan Finn
  • Publication number: 20200163758
    Abstract: A method of augmenting the length of a native leaflet to improve leaflet coaptation includes delivering a cutting tool to a surgical site adjacent the native leaflet, cutting a slit through the native leaflet, inserting a collapsible and expandable occlusion device into the slit, expanding the occlusion device, engaging a first surface of the first disk with a first surface of the native leaflet, and engaging a second surface of the second disk with a second surface of the native leaflet opposite the first surface. The occlusion device includes a first disk, a second disk, and an intermediate portion coupling the first disk to the second disk.
    Type: Application
    Filed: August 27, 2019
    Publication date: May 28, 2020
    Applicant: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Jay Reimer, Brandon Moore, Chad Joshua Green, Paul E. Ashworth, Neelakantan Saikrishnan
  • Publication number: 20200085576
    Abstract: An apparatus for stabilizing a prosthetic heart valve within an atrioventricular valve includes a collapsible and expandable stent having an inflow end, an outflow end, and struts forming a plurality of cells connected to one another in a plurality of annular rows around the stent. The stent further includes a collapsible and expandable valve assembly secured to the stent. The valve assembly includes a cuff and a plurality of leaflets having an open configuration and a closed configuration. A cord connected to the stent includes an attachment device adapted to couple the stent to heart tissue of a patient. A method of stabilizing a prosthetic heart valve within an atrioventricular valve annulus is also described.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 19, 2020
    Applicant: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Jay Reimer, Brandon Moore, Chad Joshua Green, Paul E. Ashworth, Neelakantan Saikrishnan
  • Patent number: 10537287
    Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: January 21, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim, Steven Frederick Anderl, Jason White, Paul E. Ashworth, Morgan Low, Loell Boyce Moon, Neelakantan Saikrishnan
  • Publication number: 20190321170
    Abstract: A surgical heart valve includes a non-collapsible frame having features that enable the frame to expand from an initial condition having a first diameter to an expanded condition having a second diameter larger than the first diameter after the valve has been implanted within a patient. The frame may include members that prevent the unintended expansion of the frame, such as during implantation, and members that prevent the over-expansion of the frame. The surgical heart valve further includes a valve assembly connected to the frame and including a plurality of leaflets.
    Type: Application
    Filed: April 18, 2019
    Publication date: October 24, 2019
    Applicant: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Chad Joshua Green, Neelakantan Saikrishnan, Paul E. Ashworth, Scott R. Lien
  • Patent number: 10433791
    Abstract: A prosthetic device for implanting in a patient's heart includes (i) a therapeutic device capable of restoring function to a native heart valve; and (ii) at least one sensor including a body, an inductor coil disposed within the body, and a capacitor in communication with the inductor coil, the at least one sensor being coupled to the therapeutic device, and being configured to monitor proper function of the therapeutic device within the patient's heart.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: October 8, 2019
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim, Loell Boyce Moon, Paul E. Ashworth, Neelakantan Saikrishnan, Steven Frederick Anderl
  • Publication number: 20190247184
    Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.
    Type: Application
    Filed: April 23, 2019
    Publication date: August 15, 2019
    Applicant: St. Jude Medical, LLC
    Inventors: Peter N. Braido, Paul E. Ashworth, Julia Ann Schraut
  • Patent number: 10314694
    Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: June 11, 2019
    Assignee: St. Jude Medical, LLC
    Inventors: Peter N. Braido, Paul E. Ashworth, Julia Schraut
  • Publication number: 20190117841
    Abstract: Methods of preparing biological tissue for bioprosthetic valves include providing fresh biological tissue; treating the tissue with an aqueous cellulose solution for a time sufficient to allow the fluid in the tissue to be replaced by the aqueous cellulose solution; and cross-linking the tissue, wherein the treating step is performed prior to, during, after, or both prior to and after the cross-linking step. The methods may include storing the cellulose-treated and cross-linked tissue in an aqueous solution; or drying the cellulose-treated and cross-linked tissue by a vacuum-drying or lyophilization process, and storing the dried tissue in a dry, ambient environment. The treated tissue may be in the form of a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.
    Type: Application
    Filed: April 28, 2017
    Publication date: April 25, 2019
    Applicant: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Paul E. Ashworth
  • Publication number: 20190001023
    Abstract: Methods of preparing calcification-resistant bioprosthetic tissue include providing fresh biological tissue, cross-linking the tissue, treating the cross-linked tissue with an alcohol for a time sufficient to allow the alcohol to be diffused into the tissue, and treating the alcohol-treated fixed tissue with a polyol for a time sufficient to allow fluid in the tissue to be replaced by the polyol. The methods may include sterilizing the cross-linked tissue in a solution including propylene oxide or peracetic acid either before or after the alcohol treatment step; or drying the alcohol/polyol-treated, cross-linked tissue, sterilizing the dried tissue by exposure to ethylene oxide or peracetic acid, and storing the sterilized tissue in a dry, ambient environment. The treated tissue may be a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.
    Type: Application
    Filed: June 29, 2018
    Publication date: January 3, 2019
    Applicant: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Paul E. Ashworth, Chad Joshua Green, Jay Reimer, Katherine A. Ahmann, David A. Panus
  • Publication number: 20180246094
    Abstract: Methods of preparing a solid reference material so as to elicit a positive control response when tested for in-vitro complement activation include providing biological tissue; treating the tissue with an aqueous cellulose solution for a time sufficient to allow fluid in the tissue to be replaced by the aqueous cellulose solution; drying the cellulose-treated tissue by a vacuum-drying process or a lyophilization process to form dried tissue; and storing the dried tissue in a dry, ambient environment. The tissue prepared by these methods and its use in an in-vitro complement assay and diagnostic kit are also described.
    Type: Application
    Filed: February 27, 2018
    Publication date: August 30, 2018
    Applicant: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Paul E. Ashworth
  • Patent number: 10010413
    Abstract: A method of making a prosthetic heart valve may include providing an annular stent having a plurality of annularly spaced commissure portions having tips, covering each of the tips with a first fabric cover, covering the first fabric covers and the remainder of the stent with a second fabric cover, covering the second fabric cover with a first tissue membrane, and covering the outside of the first tissue membrane with a second tissue membrane, the second tissue membrane forming leaflet portions that extend inwardly between the commissure portions.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: July 3, 2018
    Assignee: St. Jude Medical, LLC
    Inventors: Chad Cai, Peter N. Braido, Bob Allan, Paul E. Ashworth, Steven D. Kruse, Lise LaChance
  • Publication number: 20180042555
    Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 15, 2018
    Applicant: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim, Steven Frederick Anderl, Jason White, Paul E. Ashworth, Morgan Low, Loell Boyce Moon, Neelakantan Saikrishnan
  • Patent number: 9808201
    Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: November 7, 2017
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim, Steven Frederick Anderl, Jason White, Paul E. Ashworth, Morgan Low, Loell Boyce Moon, Neelakantan Saikrishnan
  • Publication number: 20170196687
    Abstract: A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.
    Type: Application
    Filed: March 24, 2017
    Publication date: July 13, 2017
    Applicant: St. Jude Medical, LLC
    Inventors: Peter N. Braido, Paul E. Ashworth, Julia Schraut