Patents by Inventor Paul E. Kelley

Paul E. Kelley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200130248
    Abstract: A hot fill plastic container has a dome portion with a convex outer surface that defines a maximum outer diameter of the container so as to extend outwardly beyond a main body portion of the container. The generally egg-shaped dome portion enhances the crush resistance of the dome and provides a point of contact between containers when they are placed adjacent to one another. A circumferential stiffening groove may be provided near a lower end of the dome portion.
    Type: Application
    Filed: October 24, 2018
    Publication date: April 30, 2020
    Applicant: GRAHAM PACKAGING COMPANY, L.P.
    Inventors: Scott E. Bysick, JR., Paul V. Kelley
  • Publication number: 20190307735
    Abstract: This invention relates to the treatment of chronic kidney disease, including diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), nephrotic syndrome, non-diabetic chronic kidney disease, renal fibrosis or acute kidney injury by the administration of an RGD mimetic integrin receptor antagonist, either as a single agent or in combination with other agents.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 10, 2019
    Applicant: MERCK SHARP & DOHME CORP
    Inventors: Jason M. Cox, Lijun Ma, Xiaoyan Zhou, Robin E. Haimbach, Paul J. Coleman, Haihong Zhou, David E. Kelley, Selwyn Aubrey Stoch, Le T. Duong, Maarten Hoek
  • Patent number: 10322837
    Abstract: A hot fill plastic container has a dome portion with a convex outer surface that defines a maximum outer diameter of the container so as to extend outwardly beyond a main body portion of the container. The generally egg-shaped dome portion enhances the crush resistance of the dome and provides a point of contact between containers when they are placed adjacent to one another. A circumferential stiffening groove may be provided near a lower end of the dome portion.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: June 18, 2019
    Assignee: GRAHAM PACKAGING COMPANY, L.P.
    Inventors: Scott E. Bysick, Paul V. Kelley
  • Patent number: 5864136
    Abstract: A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: January 26, 1999
    Assignee: Teledyne Electronic Technologies
    Inventors: Paul E. Kelley, John N. Louris
  • Patent number: 5703358
    Abstract: A method for generating a filtered noise signal, which includes the steps of generating a broadband signal having optimized (reduced or minimized) dynamic range, and filtering the broadband signal in a notch filter to generate a broadband signal whose frequency-amplitude spectrum has one or more notches (the "filtered noise" signal). In preferred embodiments, the filtered noise signal is a voltage signal suitable for application to an ion trap during a mass spectrometry operation. The invention enables rapid generation of different filtered noise signals (for use in different mass spectrometry experiments) by filtering a single, optimized broadband signal using a set of different notch filters, each having a simple, easily implementable design.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: December 30, 1997
    Assignee: Teledyne Electronic Technologies
    Inventors: Doneil J. Hoekman, Paul E. Kelley
  • Patent number: 5679951
    Abstract: A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: October 21, 1997
    Assignee: Teledyne Electronic Technologies
    Inventors: Paul E. Kelley, John N. Louris
  • Patent number: 5610397
    Abstract: A mass spectrometry method in which one or more high power supplemental AC voltage signals and one or more low power supplemental AC voltage signals are applied to an ion trap. The frequency of each supplemental AC voltage is selected to match a resonance frequency of an ion having a desired mass-to-charge ratio. The low power supplemental voltage signals are applied for the purpose of dissociating specific ions (i.e., parent ions) within the trap, and the high power supplemental voltage signals are applied to resonate products of the dissociation process (i.e., daughter ions) so that they can be detected. In one class of embodiments, the high power voltage signals resonate daughter ions out from the trap for detection by an external detector.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: March 11, 1997
    Assignee: Teledyne Electronic Technologies
    Inventor: Paul E. Kelley
  • Patent number: 5561291
    Abstract: A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: October 1, 1996
    Assignee: Teledyne Electronic Technologies
    Inventors: Paul E. Kelley, John N. Louris
  • Patent number: 5508516
    Abstract: A mass spectrometry method in which one or more high power supplemental AC voltage signals and one or more low power supplemental AC voltage signals are applied to an ion trap. The frequency of each supplemental AC voltage is selected to match a resonance frequency of an ion having a desired mass-to-charge ratio. The low power supplemental voltage signals are applied for the purpose of dissociating specific ions (i.e., parent ions) within the trap, and the high power supplemental voltage signals are applied to resonate products of the dissociation process (i.e., daughter ions) so that they can be detected. In one class of embodiments, the high power voltage signals resonate daughter ions out from the trap for detection by an external detector.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: April 16, 1996
    Assignee: Teledyne ET
    Inventor: Paul E. Kelley
  • Patent number: 5466931
    Abstract: A mass spectrometry method in which notch-filtered noise is applied to an ion trap to resonate all ions except selected parent ions out of the region of the trapping field. Preferably, the trapping field is a quadrupole trapping field defined by a ring electrode and a pair of end electrodes positioned symmetrically along a z-axis, and the filtered noise is applied to the ring electrode(rather than to the end electrodes) to eject unwanted ions in radial directions (toward the ring electrode) rather than toward a detector mounted along the z-axis. Application of the filtered noise to the trap in this manner can significantly increase the operating lifetime of such an ion detector. Also preferably, the trapping field has a DC component selected so that the trapping field has both a high frequency and low frequency cutoff, and is incapable of trapping ions with resonant frequency below the low frequency cutoff or above the high frequency cutoff.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: November 14, 1995
    Assignee: Teledyne ET a div. of Teledyne Industries
    Inventor: Paul E. Kelley
  • Patent number: 5449905
    Abstract: A method for generating a filtered noise signal, which includes the steps of generating a broadband signal having optimized (reduced or minimized) dynamic range, and filtering the broadband signal in a notch filter to generate a broadband signal whose frequency-amplitude spectrum has one or more notches (the "filtered noise" signal). In preferred embodiments, the filtered noise signal is a voltage signal suitable for application to an ion trap during a mass spectrometry operation. The invention enables rapid generation of different filtered noise signals (for use in different mass spectrometry experiments) by filtering a single, optimized broadband signal using a set of different notch filters, each having a simple, easily implementable design.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: September 12, 1995
    Assignee: Teledyne ET
    Inventors: Doneil J. Hoekman, Paul E. Kelley
  • Patent number: 5436445
    Abstract: A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: July 25, 1995
    Assignee: Teledyne Electronic Technologies
    Inventors: Paul E. Kelley, John N. Louris
  • Patent number: 5381007
    Abstract: A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially, for example for detection. The improved field can also include a supplemental field of different spatial form. The changing improved field can sequentially eject selected ones of the trapped ions from the improved field for detection (or other purposes). An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: January 10, 1995
    Assignee: Teledyne MEC a division of Teledyne Industries, Inc.
    Inventor: Paul E. Kelley
  • Patent number: 5345078
    Abstract: A mass spectrometry method in which notch-filtered noise is applied to an ion trap to resonate all ions except selected parent ions out of the region of the trapping field. Preferably, the trapping field is a quadrupole trapping field defined by a ring electrode and a pair of end electrodes positioned symmetrically along a z-axis, and the filtered noise is applied to the ring electrode (rather than to the end electrodes) to eject unwanted ions in radial directions (toward the ring electrode) rather than toward a detector mounted along the z-axis. Application of the filtered noise to the trap in this manner can significantly increase the operating lifetime of such an ion detector. Also preferably, the trapping field has a DC component selected so that the trapping field has both a high frequency and low frequency cutoff, and is incapable of trapping ions with resonant frequency below the low frequency cutoff or above the high frequency cutoff.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: September 6, 1994
    Assignee: Teledyne MEC
    Inventor: Paul E. Kelley
  • Patent number: 5274233
    Abstract: A mass spectrometry method in which one or more high power supplemental AC voltage signals and one or more low power supplemental AC voltage signals are applied to an ion trap. The frequency of each supplemental AC voltage is selected to match a resonance frequency of an ion having a desired mass-to-charge ratio. The low power supplemental voltage signals are applied for the purpose of dissociating specific ions (i.e., parent ions) within the trap, and the high power supplemental voltage signals are applied to resonate products of the dissociation process (i.e., daughter ions) so that they can be detected. In one class of embodiments, the high power voltage signals resonate daughter ions out from the trap for detection by an external detector.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: December 28, 1993
    Assignee: Teledyne Mec
    Inventor: Paul E. Kelley
  • Patent number: 5256875
    Abstract: A method for generating a filtered noise signal, which includes the steps of generating a broadband signal having optimized (reduced or minimized) dynamic range, and filtering the broadband signal in a notch filter to generate a broadband signal whose frequency-amplitude spectrum has one or more notches (the "filtered noise" signal). In preferred embodiments, the filtered noise signal is a voltage signal suitable for application to an ion trap during a mass spectrometry operation. The invention enables rapid generation of different filtered noise signals (for use in different mass spectrometry experiments) by filtering a single, optimized broadband signal using a set of different notch filters, each having a simple, easily implementable design.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: October 26, 1993
    Assignee: Teledyne MEC
    Inventors: Doneil J. Hoekman, Paul E. Kelley
  • Patent number: 5206507
    Abstract: A mass spectrometry method in which a trapping field signal (such as a three-dimensional quadrupole trapping field signal or other multipole trapping field signal) set to store ions of interest is superimposed with a notch-filtered broadband ("filtered noise") signal, and ions are formed or injected in the resulting combined field. The filtered noise signal resonates all ions (except selected ones of the ions) from the combined field, so that only selected ones of the ions remain trapped in the combined field. The combined filtered noise and trapping field signal (the "combined signal") is then changed to excite the trapped ions sequentially, so that the excited ions can be detected sequentially. The invention can be applied to perform an (MS).sup.n or CI, or combined CI/(MS).sup.n, mass spectrometry operation.
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: April 27, 1993
    Assignee: Teledyne MEC
    Inventor: Paul E. Kelley
  • Patent number: 5200613
    Abstract: A mass spectrometry method in which a supplemental AC voltage signal having at least one high power frequency component, and at least one low power frequency component, is applied to an ion trap. Each high power component has an amplitude sufficiently large to eject one or more selected ions from the trap, by resonantly exciting the ions. Each low power component has an amplitude sufficient to induce dissociation (or reaction) of one or more selected ions, but insufficient to resonate the ions for detection. The frequency (or band of frequencies) of each high and low power frequency component is selected to match a resonance frequency of ions having a desired mass-to-charge ratio. Each low power component is applied for the purpose of inducing dissociation or reaction of specific trapped ions, which may be parent, daughter, reagent, or product ions, and each high power component is applied to eject undesired products of each such dissociation or reaction process from the trap.
    Type: Grant
    Filed: August 30, 1991
    Date of Patent: April 6, 1993
    Assignee: Teledyne MEC
    Inventor: Paul E. Kelley
  • Patent number: 5196699
    Abstract: A mass spectrometry method in which notch-filtered noise is applied to an ion trap to resonate all ions except selected reagent ions out of the region of the trapping field. Preferably, the trapping field is a quadrupole trapping field defined by a ring electrode and a pair of end electrodes positioned symmetrically along a z-axis, and the filtered noise is applied to the ring electrode to eject unwanted ions in radial directions rather than toward a detector mounted along the z-axis. Also preferably, the trapping field has a DC component selected so that the trapping field has both a high frequency and low frequency cutoff, and is incapable of trapping ions with resonant frequency below the low frequency cutoff or above the high frequency cutoff. Application of the filtered noise signal to such a trapping field is functionally equivalent to filtration of the trapped ions through a notched bandpass filter having such high and low frequency cutoffs.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: March 23, 1993
    Assignee: Teledyne MEC
    Inventor: Paul E. Kelley
  • Patent number: 5187365
    Abstract: A method for performing mass analysis with dynamic mass resolution, in which a time-varying notch filtered broadband voltage signal (sometimes denoted as a time-varying "filtered noise" signal) is applied to a quadrupole mass filter. The time-varying filtered noise signal can consist of a rapid sequence of static (time-invariant) filtered noise signals, each defining a notch having a selected width and center location. The invention facilitates performance of mass analysis over a wide range of ion mass-to-charge ratios ("mass ranges") with adequate mass resolution. By appropriately choosing the width of each notch in the applied time-varying filtered noise, mass analysis can be performed with substantially constant mass separation over a wide mass range.
    Type: Grant
    Filed: November 6, 1991
    Date of Patent: February 16, 1993
    Assignee: Teledyne MEC
    Inventor: Paul E. Kelley