Abstract: Provided herein are purification, production and manufacturing methods for recombinant viral vector particles such as recombinant adeno-associated viral (rAAV) vector particles substantially free of empty viral particles; a population of recombinant adeno-associated vims (rAAV) particles purified using the method described herein, and a pharmaceutical composition comprising the purified rAAV.

Abstract: A fuel pick-up device (10) for a fuel tank (13) has a head (11) for fitting to a wall of the tank (13), and an elongate body (14) which extends from the head (11) into the tank (13). A water separator disposed in body comprises an axially-extending separation chamber (18), and a vane (21) for creating a helical flow of fuel flowing through the chamber between an inlet (17) and an outlet (23), wherein any water in the fuel entering the separation chamber through the inlet (17) moves radially outwardly in the helical flow away from the outlet (23), the outlet (23) being arranged such that fuel drawn from the chamber (18) is substantially free of water. Water separated from the fuel is collected in a chamber (25) and can be removed via a drain (24).

Abstract: An administration device for intravitreal administration of a fluid, wherein a first actuation part of the administration device is rotatable in order to axially move a main unit acting on a stopper by means of a leadscrew, wherein a drive spring is partially releasable by actuating the first actuation part and at least partially releasable by actuating a second actuation part of the administration device, wherein a blocking element of the actuation device axially blocks the main unit both in an administration position and a final position of a main unit and/or wherein an indicator part of the administration device is rotatable by the axial movement of the main unit.

Abstract: Reader and plate methods, operations, and systems for observing a biological sample are shown and described. In one embodiment, a device for observing biological growth, when present, on a growth plate, includes an imaging device and a variable positioning nest. The nest may include a first sunken frame to receive a first growth plate, and an offset second sunken frame to receive a distinct second growth plate in an operating position offset about the first operating position.

Abstract: Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay when contacted with a sample includes a non-planar optics module to align the assay in an offset testing position. A modular interface assembly may support a motherboard and at least one non-planar optics module.

Abstract: An email message body is processed to identify groups of characters that match patterns from a set of predefined signature data patterns. For each identified group of characters, a respective block of the email message body is reviewed to identify other groups of characters within the respective block that also match patterns from the set of predefined signature data patterns. A block score is generated for the respective block based on the groups of characters identified as matching patterns from the set of predefined signature data patterns. One of the blocks is selected based on the block scores generated for the respective blocks, and signature contact information is retrieved from the selected block.

Abstract: A fuel pick-up device (10) for a fuel tank (13) has a head (11) for fitting to a wall of the tank (13), and an elongate body (14) which extends from the head (11) into the tank (13). A water separator disposed in body comprises an axially-extending separation chamber (18), and a vane (21) for creating a helical flow of fuel flowing through the chamber between an inlet (17) and an outlet (23), wherein any water in the fuel entering the separation chamber through the inlet (17) moves radially outwardly in the helical flow away from the outlet (23), the outlet (23) being arranged such that fuel drawn from the chamber (18) is substantially free of water. Water separated from the fuel is collected in a chamber (25) and can be removed via a drain (24).

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: A dosing device includes a rod element and a shell. The rod element has a stem with a longitudinal axis and a first thread arrangement. The shell has a second thread arrangement. The first thread arrangement of the rod element or the second thread arrangement of the shell includes a thread. The first thread arrangement of the rod element and the second thread arrangement of the shell engage. The rod element is movable along the longitudinal axis of its stem by rotating the shell and the rod element relative to each other causing the first thread arrangement of the rod element and the second thread arrangement of the shell to travel along each other. A dosage chamber is formed by moving the rod element along the longitudinal axis of its stem. The volume of the dosage chamber is varied by moving the rod element along the longitudinal axis of its stem. An inclination angle (?, ?) of the thread varies along the thread.

Abstract: A medical delivery device is disclosed having a rod element and a dosage member. The rod element has a stem and a first thread arrangement. The dosage member includes a delivery orifice, a chamber body and a second thread arrangement. The stem of the rod element extends within the chamber body and the delivery orifice is arranged adjacent to a proximal end of the stem. The dosage chamber is formed within the chamber body between the stem and the delivery orifice such that the dosage chamber increases when the rod element moves away from the delivery orifice. In a dosing status, the first thread arrangement of the rod element engages the second thread arrangement of the dosage member such that the rod element is moveable along its longitudinal axis relative to the delivery orifice of the dosage member.

Abstract: A medical delivery device is disclosed including a rod element, a dosage member and a lock mechanism. The rod element has a stem and the dosage member includes a delivery orifice and a chamber body. The stem of the rod element extends into the chamber body and the delivery orifice is arranged adjacent to a proximal end of the stem. In a dosing status, the rod element is movable along its longitudinal axis relative to the delivery orifice, wherein a dosage chamber is formed within the chamber body between the stem and the delivery orifice such that the dosage chamber increases when the rod element moves away from the delivery orifice. The lock mechanism is adapted to change the medical delivery device from a lock status to a dosing status, wherein, in the lock status moving the rod element along its longitudinal axis relative to the delivery orifice is prevented.

Abstract: A medical delivery device is disclosed that includes a rod element, a dosage member and a lock mechanism. A stem of the rod element extends into an interior of a chamber body of the dosage member and a delivery orifice of the dosage member is arranged adjacent to a proximal end of the stem of the rod element. In a dosing status, the rod element is movable relative to the delivery orifice of the dosage member, such that a dosage chamber is formed within the chamber body between the stem of the rod element and the delivery orifice, wherein the dosage chamber increases when the rod element moves away from the delivery orifice. The lock mechanism changes the medical delivery device from a lock status to the dosing status, wherein in the lock status the rod element is prevented from moving relative to the dosage member delivery orifice.

Abstract: A medical delivery device is disclosed having a rod element with a stem and a first thread arrangement, a dial shell with a second thread arrangement, a delivery orifice, and a switching mechanism. In a dosing status, the rod element is movable relative to the delivery orifice by rotating the dial shell around the stem causing the first thread arrangement and the second thread arrangement to travel along each other, a dosage chamber is formed between the rod element and the delivery orifice when the rod element moves away from the delivery orifice, and the rod element is prevented from movement along a longitudinal axis when an axial force is applied. In a delivery status, the rod element is movable along the longitudinal axis relative to the delivery orifice when an axial force is applied and moving the rod element by rotating the dial shell around the stem is prevented.

Abstract: An email message body is processed to identify groups of characters that match patterns from a set of predefined signature data patterns. For each identified group of characters, a respective block of the email message body is reviewed to identify other groups of characters within the respective block that also match patterns from the set of predefined signature data patterns. A block score is generated for the respective block based on the groups of characters identified as matching patterns from the set of predefined signature data patterns. One of the blocks is selected based on the block scores generated for the respective blocks, and signature contact information is retrieved from the selected block.

Abstract: A fuel pick-up device (11) for a fuel tank (10) comprises a float (17) arranged for rising and falling with the level of fuel (F) in the tank (10) and a plurality of elongate flexible tubes (16a, 16b) extending helically from the float (17) to a fuel outlet (15) of the device (11), the float (17) being arranged for generally vertical movement within an apertured sleeve (13). The flexible tubes (16a, 16b) are sufficiently thin to allow the float (17) to freely rise and fall with the level of the fuel (F). However, the combined cross-sectional area of the ducts provided by the plurality of flexible tubes (16a, 16b) is sufficient to allow fuel to be drawn from the tank at a high flow rate sufficient for large engines.

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: A fiber optic transceiver FPGA mezzanine card (FMC) is capable of operating in radiation environments. The fiber optic transceiver FMC may be used with radiation-hardened and non-hardened FPGAs. The FMC may enable high speed serial communications, such as gigabit Ethernet, PCI express, serial rapid IO, and/or other high speed serial protocols over the fiber.

Abstract: A medical delivery device (1; 10) comprises a rod element (3; 30), a dosage member (6; 60) and a lock mechanism. The rod element (3; 30) has a stem (31; 310) with a longitudinal axis (38; 380), a distal end and a proximal end. The dosage member (6; 60) comprises a delivery orifice (62; 620) and a chamber body (61; 610) with a distal end, a proximal end and a hollow interior. The stem (31; 310) of the rod element (3; 30) extends into the interior of the chamber body (61; 610) of the dosage member (6; 60) and the delivery orifice (62; 620) is arranged adjacent to the proximal end of the stem (31; 310) of the rod element (3; 30).

Abstract: A medical delivery device (1) comprises a rod element (3), a dial shell (4), a delivery orifice (62) and a switching mechanism (7, 36). The rod element (3) has a stem (31) with a longitudinal axis (38), a first thread arrangement (35, 36), a proximal end and a distal end. The dial shell (4) has a second thread arrangement (411). The delivery orifice (62) is arranged adjacent to the proximal end of the stem (31) of the rod element (3). The switching mechanism (7, 36) is arranged for changing the medical delivery device (1) from a dosing status to a delivery status.