Abstract: A medical delivery device (1; 10) comprises a rod element (3; 30), a dosage member (6; 60) and a lock mechanism. The rod element (3; 30) has a stem (31; 310) with a longitudinal axis (38; 380), a distal end and a proximal end. The dosage member (6; 60) comprises a delivery orifice (62; 620) and a chamber body (61; 610) with a distal end, a proximal end and a hollow interior. The stem (31; 310) of the rod element (3; 30) extends into the interior of the chamber body (61; 610) of the dosage member (6; 60) and the delivery orifice (62; 620) is arranged adjacent to the proximal end of the stem (31; 310) of the rod element (3; 30).

Abstract: Medical delivery device (10) comprises a rod element (30) and a dosage member (60). The rod element (30) has a stem (310) with a longitudinal axis (380), a first thread arrangement (3320, 3330), a distal end and a proximal end. The dosage member (60) comprises a delivery orifice (620) and a chamber body (610) with a distal end, a proximal end and a hollow interior. The stem (310) of the rod element (30) extends into the interior of the chamber body (610) of the dosage member (60) and the delivery orifice (620) is arranged adjacent to the proximal end of the stem (310) of the rod element (30). In a dosing status of the medical delivery device (10), the rod element (30) is movable along its longitudinal axis (380) relative to the delivery orifice (620) of the dosage member (60) by the first thread arrangement (3320, 3330) of the stem (310) of the rod element (30) and a second thread arrangement (650) travelling along each other.

Abstract: A dosing device includes a rod element and a shell. The rod element has a stem with a longitudinal axis and a first thread arrangement. The shell has a second thread arrangement. The first thread arrangement of the rod element or the second thread arrangement of the shell includes a thread. The first thread arrangement of the rod element and the second thread arrangement of the shell engage. The rod element is movable along the longitudinal axis of its stem by rotating the shell and the rod element relative to each other causing the first thread arrangement of the rod element and the second thread arrangement of the shell to travel along each other. A dosage chamber is formed by moving the rod element along the longitudinal axis of its stem. The volume of the dosage chamber is varied by moving the rod element along the longitudinal axis of its stem. An inclination angle (?, ?) of the thread varies along the thread.

Abstract: The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy

Abstract: A sheet feeder comprises a feed deck for supporting a stack of sheets (65) to be fed. The feed deck may be formed by a bed of freely spinning rollers. A feed block (62) comprises a friction pad (66) that projects from the bottom of the feed block (62) towards a drive belt (42) to define a gate therebetween. The drive belt (42) frictionally engages the underside of a bottom sheet of the stack (65) and urges the sheet towards the gate. The feed block (62) comprises a front face (72) immediately upstream from the gate, which is inclined at a sharp angle to the feed direction. The friction pad (66) comprises a lower face that is substantially parallel to the feed direction and does not intersect the plane of the feed block front face (72).

Abstract: A system and method for controlling access to portable computing devices are disclosed. Identification information of a user is obtained and a portable computing device to be assigned to a particular user is selected from the plurality of portable computing devices. An association of the user and the selected portable computing device is recorded within a database. The selected portable computing device is then unlocked for use by the user. The portable computing devices may be secured in a multi-bay charging station with each bay including a mechanical lock which is controlled independently of the mechanical lock for each of the other bays. The checked-in portable computing device may be locked in the multi-bay charging station and the user and the checked-in portable computing device may then be dissociated.

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: The invention provides compounds of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom ? with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom ? with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R1 is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims.

Abstract: A modular trailer system is described, wherein a gooseneck, deck, and dolly are attachable to each other in a variety of ways. One configuration allows the gooseneck and dolly to be attached to either end of the deck. Another configuration allows the gooseneck and dolly to be attached directly to each other. This permits the method of transporting a deck to a site, and then returning the gooseneck and dolly to another location.

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: The invention provides compounds of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom ? with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom ? with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R1 is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims.

Abstract: A system including a DCU with a DMS located on the first node, where the DMS is associated with an interrupt receive register. The system further includes a second DCU located on second node that includes a GMS located on the second node, where the GMS is associated with an interrupt dispatch register. The GMS is configured to identify the DMS, determine a payload to transmit to DMS, issue cross-calls using the interrupt dispatch register, where a cross-call is issued for each non-zero bit in the payload, and issue a cross-call including a completion vector. The DCU is configured to receive the cross-calls from the GMS, in response to each of the cross-calls, set a corresponding bit-location in the second interrupt receive register to one, and after receiving the completion vector, use a current state of the interrupt receive register to determine a physical address.

Abstract: A sheet feeder comprises a feed deck for supporting a stack of sheets (65) to be fed. The feed deck may be formed by a bed of freely spinning rollers. A feed block (62) comprises a friction pad (66) that projects from the bottom of the feed block (62) towards a drive belt (42) to define a gate therebetween. The drive belt (42) frictionally engages the underside of a bottom sheet of the stack (65) and urges the sheet towards the gate. The feed block (62) comprises a front face (72) immediately upstream from the gate, which is inclined at a sharp angle to the feed direction. The friction pad (66) comprises a lower face that is substantially parallel to the feed direction and does not intersect the plane of the feed block front face (72).

Abstract: The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g.

Abstract: The invention provides a compound for use as a protein kinase B inhibitor, the compound being a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; J1-J2 is N?C(R6), (R7)C?N, (R8)N—C(O), (R8)2C—C(O), N?N or (R7)C?C(R6); E is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from O, N and S; Q1 is a bond or a saturated C1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by CONRq or NRqCO where Rq is hydrogen or methyl, or Rq is a C1-4 alkylene chain linked to R or a carbon atom of Q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group Q1 may optionally bear one or more substituents selected from fluorine and hydroxy; Q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the

Abstract: A modular trailer system is described, wherein a gooseneck, deck, and dolly are attachable to each other in a variety of ways. One configuration allows the gooseneck and dolly to be attached to either end of the deck. Another configuration allows the gooseneck and dolly to be attached directly to each other. This permits the method of transporting a deck to a site, and then returning the gooseneck and dolly to another location.