Abstract: Provided are methods and compositions for prolonging survival and/or reducing or inhibiting tumor growth in a cancer subject receiving a regimen of one or more chemotherapeutic agents, an inhibitor of soluble epoxide hydrolase (sEHi) and a non-steroidal anti-inflammatory drug (NSAID) that inhibits one or more enzymes selected from the group consisting of cyclo-oxygenase (“COX”)-1, COX-2, and 5-lipoxygenase (“5-LOX”). The methods and compositions decrease toxicity and/or adverse side effects in subjects receiving a regimen of one or more chemotherapeutic agents.

Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient or a sample from the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.

Abstract: A solar roof tile with an integrated cable management system includes a roof tile weighing less than 400 lbs per 100 square feet of installed roof area and a photovoltaic solar panel attached to a front side of the roof tile. A rear side of the roof tile includes one or more channels configured to accommodate one or more electrical power cables. A method of routing and securing electrical power cables for a solar roof installation using the solar roof tiles is also disclosed.

Abstract: A plurality of dough pieces are produced using a rotary dough cutter including a shaft, a plurality of walls extending radially outward from the shaft and a plurality of interior blades extending radially outward from the shaft. The plurality of walls define a plurality of dough cutter molds. The plurality of dough cutter molds include a first dough cutter mold and a second dough cutter mold. A first wall of the plurality of walls defines part of both the first dough cutter mold and the second dough cutter mold. Each of the plurality of interior blades is located in one of the plurality of dough cutter molds. The plurality of dough pieces are cut from a dough sheet with the plurality of walls. The plurality of dough pieces are scored with the plurality of interior blades. After scoring, the plurality of dough pieces are proofed and then frozen.

Abstract: Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more lysoplipids.

Abstract: A system for reducing the transmission of vibration from a first vibrating body to a second body, the system having a first part connected to the first vibrating body, a second part connected to the second body and an electro-hydrostatic actuator connected to the first and second parts, the electro-hydrostatic actuator being operable to continuously oscillate the first and second parts 10 relative to each other at a frequency substantially corresponding to the frequency of vibration of the first vibrating body.

Abstract: Nanolipoprotein particles having at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described. The membrane lipid component includes at least one or more membrane forming lipids, one or more polymerized lipids and/or one or more polymerizable lipids.

Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.

Abstract: A trotline organizing and storage device includes a tube having a first end, which is closed, and a second end, which is open. A slot, positioned in a wall of the tube, extends from the second end to proximate to the first end. A rod is coupled to the first end and extends axially through the tube to proximate to the second end. The rod configured to position a fishhook of a trotline around the rod. Adjacent fishhooks of the trotline then are sequentially positionable upon the rod until all of the fishhooks are stowed within the tube. The shanks of the fishhooks are positioned through the slot such that line attached to eyes of the fishhooks is positioned outside of the tube. A cover is configured to reversibly couple to the second end to retain the fishhooks within the tube.

Abstract: The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a polyethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

Abstract: Provided herein are nanolipoprotein particles that comprise a membrane associated hydrogenase and related assemblies, devices, methods and systems.

Abstract: The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

Abstract: Provided herein are methods and systems for assembling, solubilizing and/or purifying a membrane associated protein in a nanolipoprotein particle, which comprise a temperature transition cycle performed in presence of a detergent, wherein during the temperature transition cycle the nanolipoprotein components are brought to a temperature above and below the gel to liquid crystalling transition temperature of the membrane forming lipid of the nanolipoprotein particle.

Abstract: A process of bringing first and second data sets into registration/conformity with each other. A plurality of candidate data sets are provided, each being a differently shifted or distorted form of a reference data set. Each of the first and second data sets and the reference data set being a representation of a particular physical object. The process compares respectively the first and second data sets with each of the candidate data sets and in dependence on the comparisons to determine respective first and second transformations that bring into registration or conformity with each other the reference data set and a particular candidate data set out of the plurality of candidate data sets which provides a best match with the respective first and second data sets, and brings the first and second data sets into registration/conformity with each other in dependence on the first and second transformations.

Abstract: A mobile device is configured to execute encrypted source files and includes a transceiver configured to receive an archive file comprising encrypted source files. The mobile device also includes a storage unit configured to store the received archive file. A local web server in the mobile device is configured to interpret a format of the received archive file, retrieve at least one source file from the archive file in response to a request from a device browser, decrypt the retrieved source file, and forward unencrypted information associated with the decrypted source file to the device browser. The device browser in the mobile device is configured to display the unencrypted information.

Abstract: Provided herein are methods and systems for assembling, solubilizing and/or purifying a membrane associated protein in a nanolipoprotein particle, which comprise a temperature transition cycle performed in presence of a detergent, wherein during the temperature transition cycle the nanolipoprotein components are brought to a temperature above and below the gel to liquid crystalling transition temperature of the membrane forming lipid of the nanolipoprotein particle.

Abstract: A system for reducing the transmission of vibration from a first vibrating body to a second body, the system having a first part connected to the first vibrating body, a second part connected to the second body and an electro-hydrostatic actuator connected to the first and second parts, the electro-hydrostatic actuator being operable to continuously oscillate the first and second parts 10 relative to each other at a frequency substantially corresponding to the frequency of vibration of the first vibrating body.

Abstract: A mobile device is configured to execute encrypted source files and includes a transceiver configured to receive an archive file comprising encrypted source files. The mobile device also includes a storage unit configured to store the received archive file. A local web server in the mobile device is configured to interpret a format of the received archive file, retrieve at least one source file from the archive file in response to a request from a device browser, decrypt the retrieved source file, and forward unencrypted information associated with the decrypted source file to the device browser. The device browser in the mobile device is configured to display the unencrypted information.

Abstract: Provided herein are methods and systems for assembling, solubilizing and/or purifying a membrane associated protein in a nanolipoprotein particle, which comprise a temperature transition cycle performed in presence of a detergent, wherein during the temperature transition cycle the nanolipoprotein components are brought to a temperature above and below the gel to liquid crystalling transition temperature of the membrane forming lipid of the nanolipoprotein particle.

Abstract: The present invention relates to a process of bringing first (30) and second (32) data sets into registration or conformity with each other by electronic methods. Each of the first and second data sets (30, 32) is a representation of a particular physical object. The process comprises having a plurality of candidate data sets, each candidate data set being a differently shifted or distorted form of a reference data set (34), the reference data set being a representation of the physical object. The process further comprises comparing the first data set (30) with each of the candidate data sets and in dependence on the comparisons determining a first transformation that brings the candidate data set, which of the plurality of candidate data sets provides a best match with the first data set, and the reference data set (34) into registration or conformity with each other.