Abstract: Methods for reducing the progression of ER+breast cancer in a patient are provided, the methods comprising administering to the patient an effective amount of lasofoxifene or a pharmaceutically acceptable salt thereof and an effective amount of a CDK4/6 inhibitor (CDK4/6i), wherein the breast cancer: (i) is estrogen receptor positive (ER+); (ii) has at least one gain of function missense mutation within the ligand binding domain (LBD) of the Estrogen Receptor 1 (ESR1) gene; and (iii) has progressed during prior CDK4/6 inhibitor therapy and/or has an oncogenic mutation in a gene other than ESR1.

Abstract: An exemplary trim assembly comprises an escutcheon, a drive spindle, a lock mechanism, a cam mechanism, and a driver. The drive spindle is mounted to the escutcheon for rotation about a longitudinal axis. The lock mechanism includes a lock gear movably mounted in the escutcheon. The cam mechanism includes a first cam defined by the escutcheon and a second cam defined by the lock gear. The driver is operable to rotate the lock gear between a first rotational position and a second rotational position. The cam mechanism is configured to longitudinally drive the lock gear from a first longitudinal position to a second longitudinal position as the lock gear rotates from the first rotational position to the second rotational position. Movement of the lock gear between the first longitudinal position and the second longitudinal position transitions the lock mechanism between a locked state and an unlocked state.

Abstract: A catheter pump system is disclosed. The catheter pump system can include a shaft assembly and an impeller coupled with a distal portion of the shaft assembly. A motor assembly can impart rotation on the impeller through the shaft assembly, the motor assembly comprising a motor which rotates the shaft assembly. The catheter pump system can include a fluid pathway which conveys fluid proximally during operation of the catheter pump system. A seal can be disposed between the motor assembly and the impeller. The seal can be configured to impede or prevent the fluid from the fluid pathway from entering the motor assembly at least about an outer periphery of the shaft assembly. The seal can comprise an opening through which a portion of the shaft assembly extends.

Abstract: A catheter pump system is disclosed. The catheter pump system can include a shaft assembly and an impeller coupled with a distal portion of the shaft assembly. The catheter pump system can include a motor assembly, the motor assembly comprising a chamber and a shaft-driving portion disposed in the chamber. The shaft-driving portion can be configured to impart rotation to the impeller through the shaft assembly. The chamber can be filled with a gas that at least partially surrounds the shaft-driving portion. A fluid pathway can convey fluid proximally during operation of the catheter pump system. A bypass pathway can be in fluid communication with the fluid pathway, the bypass pathway configured to direct at least a portion of the fluid to bypass the chamber.

Abstract: A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen in which waste fluid flows proximally therethrough during operation of the catheter pump. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate, the rotor including a longitudinal rotor lumen therethrough. The motor assembly can also comprise a stator assembly disposed about the rotor. During operation of the catheter pump, the waste fluid flows from the lumen into the chamber such that at least a portion of the waste fluid flows proximally through the longitudinal rotor lumen.

Abstract: An electronic system comprising: at least one user interface member configured to be manipulated by a user for performing a dose setting operation of the drug delivery device and/or for performing a dose delivery operation for delivering a set dose, an electronic control unit configured to control operation of the electronic system, an electrical signaling unit configured to provide at least one electrical signal when the user interface member is manipulated, and a manipulation evaluation unit configured to evaluate the at least one electrical signal of the signaling unit to determine whether the manipulation of the user interface member indicated by the at least one signal of the signaling unit qualifies as an activation operation. The electronic control unit is configured to switch the electronic system into a higher power consumption when the manipulation evaluation unit has confirmed that the manipulation qualifies as activation operation.

Abstract: The present disclosure refers to a waveguide electromechanical relay switch having a rotor with transmission paths and an axis of rotation parallel to the base plane combined with an actuator adapted to the configuration. A 4-pol switch design enables compensation of fault cases in a relatively shortened length of transmission line, reducing potential RF loss. In one embodiment, a 4-pol rotor includes an offset transmission path that enables crossing of another path on the same rotor, providing increased functionality and fault-case recovery.

Abstract: An apparatus for insertion into an inflatable sports ball, the apparatus comprising a plate comprising a valve wherein the valve comprises an aperture for selective communication of air, a circuit board comprising a transmitter and a battery electrically connected to the circuit board.

Abstract: An apparatus for permitting electrical connection between the exterior of an inflatable sports ball and electronics located inside the inflatable sports ball is provided. The apparatus comprises a support member, the support member having separate first and second through-holes provided therein for respectively connecting the exterior of the inflatable sports ball with the interior of the inflatable sports ball. An electrical connection port is located in the first through-hole of the support member for permitting an electrical connection to be made through the first through-hole. An air valve is located in the second through-hole of the support member, the air valve comprising an aperture for selective communication of air.

Abstract: A system and accompanying methods for sanitizing indoor air is disclosed. The system may receive air from an air supply unit and analyze characteristics associated with the received air, such as by utilizing sensors of a sensor unit. Based upon the characteristics of the air, the system may direct the air along one of multiple possible pathways. In certain embodiments, the system may include determining, based on an analysis of the characteristics of the air, whether the air requires treatment and, if the air requires treatment, whether the air can be treated. Based on the analysis, the system may allow the air to pass directly into an indoor environment without treatment, activate one or more treatment modules to treat the air if the air can be treated, or activate an exhaust module to exhaust the air to another environment if the air requires treatment but cannot be treated effectively.

Abstract: An electronic system for a drug delivery device comprising a dose setting and drive mechanism with a first member, wherein the first member performs a specific movement relative to a second member during a dose delivery operation. The electronic system comprises a first switch configured to be activated by a pre-defined user operation, wherein the pre-defined user operation includes a user operation that is expected in conjunction with dose delivery operation, a second switch for indicating the specific movement, and a sensor arrangement for a motion sensor system for providing position data that allows to distinguish between different positions of the first member relative to the second member.

Abstract: A system and method for sanitizing air is disclosed. Atmospheric air is drawn into the system by a fan. The air is passed through a series of baffles to mix the air and reduce speed. The air is exposed to an emitter, such as UV-C light, to sanitize contaminants and then exhausted. The sanitized air drawn into the system and exhausted to the atmosphere without exposing UV-C light to the atmosphere.

Abstract: The present disclosure refers to a waveguide electromechanical relay switch having a rotor with transmission paths and an axis of rotation parallel to the base plane combined with an actuator adapted to the configuration. A 4-pol switch design enables compensation of fault cases in a relatively shortened length of transmission line, reducing potential RF loss. In one embodiment, a 4-pol rotor includes an offset transmission path that enables crossing of another path on the same rotor, providing increased functionality and fault-case recovery.