Patents by Inventor Paul Keim

Paul Keim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160040217
    Abstract: Embodiments of the invention provide a method of genotyping a C. gattii sample, which can include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the C. gattii genome that can provide definitive genotype information to distinguish between one or more types or subtypes of C. gattii.
    Type: Application
    Filed: August 6, 2015
    Publication date: February 11, 2016
    Applicants: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNVERSITY
    Inventors: David Engelthaler, Elizabeth Driebe, Erin Kelley, Paul Keim
  • Patent number: 9238844
    Abstract: Methods and kits used in the detection of variants of the Influenza virus are disclosed, including variants that are resistant to treatment with antiviral compositions.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: January 19, 2016
    Assignees: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY
    Inventors: Paul Keim, David Engelthaler, Elizabeth Driebe, Cindy Liu
  • Publication number: 20150259727
    Abstract: The present invention provides assays, methods and kits that may be used to detect and differentiate MRSA isolates, e.g., USA100, USA300 and USA600 strains.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 17, 2015
    Applicant: Translational Genomics Research Institute
    Inventors: Paul Keim, Elizabeth Driebe, David Engelthaler, Jolene Bowers
  • Publication number: 20150252408
    Abstract: The invention pertains to sequences, methods, and kits useful in the identification of and differentiation between Burkholderia pseudomallei and Burkholderia mallei. The methods generally involve the addition of oligonucleotides to mixtures containing nucleic acid isolated from a sample and performing nucleic acid amplification on the mixture.
    Type: Application
    Filed: May 19, 2011
    Publication date: September 10, 2015
    Applicant: TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
    Inventors: David Engelthaler, Jolene Bowers, Paul Keim
  • Patent number: 9127321
    Abstract: The present invention provides methods and kits that may be used to detect and quantify the presence of Coccidioides species. The methods include quantification PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: September 8, 2015
    Assignees: The Translational Genomics Research Institute, The Arizona Board of Regents on Behalf of Northern Arizona University
    Inventors: David Engelthaler, Elizabeth Driebe, Paul Keim
  • Publication number: 20140248630
    Abstract: The invention encompasses method of using quantitative PCR to detect fungal organisms in clinical and environmental samples to generate standards that allow the quantification of fungal organisms in the samples.
    Type: Application
    Filed: May 12, 2014
    Publication date: September 4, 2014
    Applicants: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, Arizona Board Of Regents On Behalf Of Northern Arizona University
    Inventors: Cindy Liu, Sergey Kachur, Lance Price, Paul Keim
  • Patent number: 8808993
    Abstract: Methods and kits used in the detection of the H1N1/09 influenza virus are provided. The methods include the use of nucleic acids to detect H1N1/09 generally as well as H1N1/09 variants resistant to antiviral compositions.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: August 19, 2014
    Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on Behalf of Northern Arizona University
    Inventors: Paul Keim, Elizabeth Driebe, David Engelthaler
  • Patent number: 8722335
    Abstract: The invention encompasses methods of using quantitative PCR to detect fungal organisms in clinical and environmental samples and to generate standards that allow the quantification of fungal organisms in the samples.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: May 13, 2014
    Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on Behalf of Northern Arizona University
    Inventors: Cindy Liu, Sergey Kachur, Lance Price, Paul Keim
  • Publication number: 20140011693
    Abstract: The present invention provides methods and kits that may be used to detect and quantify the presence of Coccidioides species. The methods include quantification real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.
    Type: Application
    Filed: July 5, 2013
    Publication date: January 9, 2014
    Applicant: TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
    Inventors: David Engelthaler, Elizabeth Driebe, Paul Keim
  • Publication number: 20120264135
    Abstract: The present invention provides methods and kits that may be used to detect and quantify the presence of Coccidioides species. The methods include quantification PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.
    Type: Application
    Filed: October 6, 2011
    Publication date: October 18, 2012
    Applicant: TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
    Inventors: David Engelthaler, Elizabeth Driebe, Paul Keim
  • Publication number: 20120107796
    Abstract: Methods and kits used in the detection of the H1N1/09 influenza virus are disclosed. The methods comprise methods of using the nucleic acids to detect H1N1/09 generally as well as H1N1/09 variants resistant to antiviral compositions.
    Type: Application
    Filed: November 1, 2010
    Publication date: May 3, 2012
    Applicants: ARIZONA BOARD OF REGENTS-NORTHERN ARIZONA UNIVERSITY, THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
    Inventors: PAUL KEIM, ELIZABETH DRIEBE, DAVID ENGELTHALER
  • Publication number: 20110312504
    Abstract: The present invention provides multiplex assays, methods and kits that may be used to detect and confirm the presence of MRSA in a sample. The methods include real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes. The present invention further comprises assays useful to identify and differentiate MRSA, MSSA, MRSE, MSSE, MRCNS and MSCNS in a sample.
    Type: Application
    Filed: March 18, 2011
    Publication date: December 22, 2011
    Applicant: The Translational Genomics Research Institute
    Inventors: Elizabeth Driebe, David Engelthaler, Jolene Bowers, Paul Keim
  • Publication number: 20110230363
    Abstract: The present invention provides a method, a kit and composition for determining MRSA and other Staphylococcus strain resistance to one or more antibiotic agents through detecting the presence of the respective antibiotic resistance gene. The methods include real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.
    Type: Application
    Filed: March 18, 2011
    Publication date: September 22, 2011
    Applicant: The Translational Genomics Research Institute
    Inventors: Elizabeth Driebe, David Engelthaler, Jolene Bowers, Paul Keim
  • Publication number: 20110092385
    Abstract: Methods and kits used in the detection of variants of the Influenza virus are disclosed, including variants that are resistant to treatment with antiviral compositions.
    Type: Application
    Filed: October 20, 2010
    Publication date: April 21, 2011
    Applicants: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, THE ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY
    Inventors: PAUL KEIM, DAVID ENGELTHALER, ELIZABETH DRIEBE, CINDY LIU
  • Publication number: 20100267039
    Abstract: The invention pertains to methods and kits useful in the identification of and differentiation between Coccidioides immitis and Coccidioides posadasii. The methods involve the addition of oligonucleotides to mixtures containing nucleic acid isolated from a sample and performing nucleic acid amplification on the mixture.
    Type: Application
    Filed: April 21, 2010
    Publication date: October 21, 2010
    Applicants: Translational Genomics Research Institute (TGen), Arizona Board of Regents - Northern Arizona University
    Inventors: Elizabeth Driebe, Paul Keim, Kelly Sheff, David Engelthaler
  • Publication number: 20100136555
    Abstract: The present invention provides methods for predicting the likelihood of mortality from melioidosis and detecting the presence of Burkholderia pseudomallei in a test sample.
    Type: Application
    Filed: July 7, 2008
    Publication date: June 3, 2010
    Applicant: The Arizona Board of Regents, A body corporate acting for and on behalf of Northern Arizona Univ.
    Inventors: Raymond Auerbach, Bartholomew John Currie, Apichai Tuanyok, Dave Wagner, Paul Keim
  • Publication number: 20060035236
    Abstract: Multiplex methods for discriminating among Cannabis sativa L. plants are disclosed. Eight STR loci have been identified from genomic sequences of Cannabis sativa L. plants and primer pairs and cocktails suitable for amplifying the STR by multiplex are disclosed. Polymorphisms at these loci were used to resolve genotypes into distinct groups. Kits are provided for use with multiplex instruments to identify DNA in a plant sample. The typing scheme is useful for the forensic identification of marijuana and for linking a marijuana sample to its plant source.
    Type: Application
    Filed: July 21, 2003
    Publication date: February 16, 2006
    Inventors: Paul Keim, Kristen Zinnamon
  • Publication number: 20050266492
    Abstract: MLVA methods for strain discrimination among Mycobacterium tuberculosum strains are disclosed. Nine VNTR loci have been identified from genomic sequences of Mycobacterium tuberculosum strains and primer pairs suitable for amplifying the VNTR by PCR are disclosed. Polymorphisms at these loci were used to resolve genotypes into distinct groups. This sub-typing scheme is useful for the epidemiological study of Mycobacterium tuberculosum and may be applied to the local detection of the pathological causative agent of tuberculosum.
    Type: Application
    Filed: July 13, 2005
    Publication date: December 1, 2005
    Inventors: Paul Keim, Robert Spurgiesz, James Schupp
  • Publication number: 20030235837
    Abstract: Variable number tandem repeat (VNTR) sequences have been identified in the genome of certain E. coli O157:H7 strains. It has been discovered that the VNTR sequences exhibit length polymorphism at different loci. A sub-typing system based on multiloci size analysis of VNTR is the basis of the novel molecular sub-typing system of the present invention.
    Type: Application
    Filed: December 11, 2002
    Publication date: December 25, 2003
    Inventors: Paul Keim, Christine Keys