Patents by Inventor Paul Krenitsky

Paul Krenitsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160152561
    Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: July 18, 2014
    Publication date: June 2, 2016
    Inventors: Sara Sabina HADIDA-RUAH, Corey ANDERSON, Andreas P. TERMIN, Brian Richard BEAR, Vijayalasmi ARUMUGAM, Paul KRENITSKY, James Philip JOHNSON
  • Patent number: 8883781
    Abstract: The present invention relates to compounds of formula IA-i useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: November 11, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lev T. D. Fanning, Pramod Joshi, Paul Krenitsky, Andreas Termin, Dean Wilson, Yulian Zhang
  • Patent number: 8865771
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: October 21, 2014
    Assignee: Vertex Pharamaceuticals Incorporated
    Inventors: Weichuan Caroline Chen, Paul Krenitsky, Andreas Termin, Dean Wilson
  • Patent number: 8841483
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: September 23, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Pramod Joshi, Paul Krenitsky, Jesus Gonzalez, III, Jian Wang, Dean Wilson, Andreas Termin
  • Patent number: 8809353
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: August 19, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Lev T. D. Fanning, Paul Krenitsky, Andreas Termin, Pramod Joshi, Urvi Sheth
  • Patent number: 8779197
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: July 15, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Weichuan Caroline Chen, Paul Krenitsky, Pramod Joshi, Andreas Termin, Dean Wilson
  • Publication number: 20130231370
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: January 23, 2013
    Publication date: September 5, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Weichuan Caroline Chen, Paul Krenitsky, Andreas Termin, Dean Wilson
  • Patent number: 8519137
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: August 27, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Pramod Joshi, Paul Krenitsky, Andreas Termin, Dean Wilson
  • Patent number: 8389734
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: March 5, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Weichuan Caroline Chen, Paul Krenitsky, Andreas Termin, Dean Wilson
  • Patent number: 8329702
    Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: December 11, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Lev T. D. Fanning, Paul Krenitsky, Pramod Joshi
  • Patent number: 8283354
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: October 9, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Jesus Gonzalez, Lev Fanning, Timothy Neubert, Paul Krenitsky, Pramod Joshi, Dennis Hurley, Urvi Sheth
  • Patent number: 8158637
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: April 17, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Lev T. D. Fanning, Paul Krenitsky, Andreas Termin, Pramod Joshi, Urvi Sheth
  • Patent number: 7928107
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: April 19, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Jesus Gonzalez, Lev Fanning, Timothy Neubert, Paul Krenitsky, Pramod Joshi, Dennis Hurley, Urvi Sheth
  • Publication number: 20110059984
    Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: November 8, 2010
    Publication date: March 10, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Dean Wilson, Andreas Termin, Lev T. D. Fanning, Paul Krenitsky, Pramod Joshi
  • Patent number: 7880008
    Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: February 1, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Lev T. D. Fanning, Paul Krenitsky, Pramod Joshi
  • Patent number: 7858786
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: December 28, 2010
    Assignee: Vertex Pharmaceuticals Incoropated
    Inventors: Dean Wilson, Andreas Termin, Dewey Fanning, Paul Krenitsky, Pramod Joshi, Urvi Sheth
  • Publication number: 20100249100
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Dean Wilson, Lev Fanning, Paul Krenitsky, Joshua Boger
  • Patent number: 7718658
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: May 18, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Lev Fanning, Paul Krenitsky, Joshua Boger
  • Patent number: 7705002
    Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: April 27, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas Termin, Dean Wilson, Lev T. D. Fanning, Paul Krenitsky, Pramod Joshi
  • Patent number: 7683065
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: March 23, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Dewey Fanning, Paul Krenitsky, Pramod Joshi