Patents by Inventor Paul Mola
Paul Mola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200393440Abstract: The disclosure generally relates to a method, apparatus and system for single-molecule polymerase biosensor having transition metal dichalcogenide (TMD) nanobridge for sequencing, information storage and reading. In an embodiment, the present disclosure relates to nanofabrication of biomolecular sensing devices and to the fabrication of devices for analyzing DNA and related biomolecules. In still another embodiment, the disclosure relates to a DNA-based memory system.Type: ApplicationFiled: April 6, 2020Publication date: December 17, 2020Applicant: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Chulmin Choi, Paul Mola, Barry Merriman
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Publication number: 20200385855Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: ApplicationFiled: December 31, 2019Publication date: December 10, 2020Applicant: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
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Publication number: 20200277645Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: ApplicationFiled: May 19, 2020Publication date: September 3, 2020Applicant: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Venkatesh Algarswamy Govindaraj, Paul Mola, Tim Geiser
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Publication number: 20200242482Abstract: In various embodiments, amplification-free DNA information methods, apparatus and systems are disclosed. A method of amplification-free information storage and retrieval comprises encoding digital data such as binary into nucleotide sequence motifs using an encoding scheme, and synthesizing replicate DNA molecules using an amplification-free DNA writing process. The amplification-free process of decoding the information stored in the DNA comprises exposing at least one of the replicate DNA molecules to a molecular electronics sensor that generates distinguishable signals in a measured electrical parameter of the sensor, wherein the distinguishable signals correspond to the sequence motifs, providing decoding back to the digital data.Type: ApplicationFiled: October 10, 2018Publication date: July 30, 2020Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Tim Geiser, Paul Mola, Gina Costa
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Publication number: 20200217813Abstract: A processive enzyme molecular sensor for use in a DNA data storage system is disclosed that can extract digital information suitably encoded into a synthetic DNA molecule. In various aspects, such sensors are provided in a high-density chip-based format that can provide the high throughput, low-cost and fast data extraction capability required for large scale DNA data storage systems. The sensor for reading the digital data stored in DNA molecules processes individual encoded DNA molecules directly, eliminating the need for complicated sample preparation such as making copies of DNA or clonal populations of such molecules.Type: ApplicationFiled: August 30, 2018Publication date: July 9, 2020Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Tim Geiser, Paul Mola, Gina Costa
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Publication number: 20200157595Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: ApplicationFiled: November 14, 2019Publication date: May 21, 2020Applicant: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser
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Patent number: 10648941Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.Type: GrantFiled: June 21, 2018Date of Patent: May 12, 2020Assignee: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser, Gina Costa
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Patent number: 10584410Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: GrantFiled: May 14, 2018Date of Patent: March 10, 2020Assignee: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
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Patent number: 10526696Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: GrantFiled: January 17, 2019Date of Patent: January 7, 2020Assignee: ROSWELL BIOTECHNOLOGIES, INC.Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
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Publication number: 20190383770Abstract: A sequencing device is disclosed. The sequence device includes an array of conducting electrode pairs, each pair of electrodes comprising a source and a drain electrode arrangement separated by a nanogap, the electrode array deposited and patterned on a dielectric substrate; at least one transition metal dichalcogenide (TMD) layer disposed on each pair of electrodes, wherein the TMD layer connects each source and drain electrode within each pair, and bridges each nanogap of each pair of electrodes; and a dielectric masking layer disposed on the TMD layer and comprising at least one opening that defines an exposed TMD region, wherein the at least one opening is sized so as to allow a single biomolecule to fit therein and to attach on to the exposed TMD region. In embodiments of the disclosure, the TMD layer be a defective TMD layer.Type: ApplicationFiled: November 22, 2017Publication date: December 19, 2019Applicant: Roswell Biotechnologies, Inc.Inventors: Chulmin CHOI, Sungho JIN, Barry L. MERRIMAN, Paul MOLA, Tim GEISER
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Patent number: 10508296Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: GrantFiled: June 21, 2018Date of Patent: December 17, 2019Assignee: Roswell Biotechnologies, Inc.Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser
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Publication number: 20190376925Abstract: In various aspects of the present disclosure, a sequencing device structure is disclosed. The device structure has an array of metallic conducting electrode pairs, each electrode pair defining a bridging source and drain arrangement separated by a nanogap, the electrode pairs deposited and patterned on a dielectric substrate; a graphene layer deposited onto each electrode pair bridging the source and drain electrodes in each pair, wherein each electrode pair is in electrical isolation from each other; and a dielectric masking layer contacting the graphene layer, the masking layer having an opening exposing a portion of the graphene layer directly over each nanogap, wherein each opening is dimensioned in size to accommodate at least one polymerase enzyme molecule. The graphene layer may include defective graphene.Type: ApplicationFiled: November 22, 2017Publication date: December 12, 2019Inventors: Chulmin Choi, Sungho Jin, Barry L. Merriman, Paul Mola, Tim Geiser
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Publication number: 20190355442Abstract: In various embodiments, an information storage system comprises: a writing device for synthesizing a nucleotide sequence that encodes a set of information; and a reading device for interpreting the nucleotide sequence by decoding the interpreted nucleotide sequence into the set of information, wherein the reading device comprises a molecular electronics sensor, the sensor comprising a pair of spaced apart electrodes and a molecular complex attached to each electrode to form a molecular electronics circuit, wherein the molecular complex comprises a bridge molecule and a probe molecule, and wherein the molecular electronics sensor produces distinguishable signals in a measurable electrical parameter of the molecular electronics sensor, when interpreting the nucleotide sequence.Type: ApplicationFiled: January 10, 2018Publication date: November 21, 2019Inventors: Barry L. Merriman, Tim Geiser, Paul Mola
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Patent number: 10378103Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: GrantFiled: October 4, 2018Date of Patent: August 13, 2019Assignee: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
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Publication number: 20190194801Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: ApplicationFiled: January 17, 2019Publication date: June 27, 2019Inventors: Sungho Jin, Barry L. Merriman, TIm Geiser, Chulmin Choi, Paul Mola
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Patent number: 10227694Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: GrantFiled: October 9, 2017Date of Patent: March 12, 2019Assignee: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
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Publication number: 20190033244Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: ApplicationFiled: October 4, 2018Publication date: January 31, 2019Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
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Publication number: 20190004003Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.Type: ApplicationFiled: June 21, 2018Publication date: January 3, 2019Inventors: Barry L. Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser, Gina Costa
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Patent number: 10151722Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: GrantFiled: October 27, 2017Date of Patent: December 11, 2018Assignee: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
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Patent number: 10125420Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.Type: GrantFiled: October 9, 2017Date of Patent: November 13, 2018Assignee: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola