Patents by Inventor Paul N. Devine

Paul N. Devine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSAMINASE REACTIONS
    Publication number: 20160333381
    Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
    Type: Application
    Filed: August 2, 2016
    Publication date: November 17, 2016
    Inventors: Gregory Hughes, Paul N. Devine, Fred J. Fleitz, Brendan T. Grau, John Limanto, Christopher Savile, Emily Mundorff
  • TRANSAMINASE BIOCATALYSTS
    Publication number: 20160264948
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: April 28, 2016
    Publication date: September 15, 2016
    Inventors: Christopher K. Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • Transaminase reactions
    Patent number: 9434968
    Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 6, 2016
    Assignee: Codexis, Inc.
    Inventors: Gregory Hughes, Paul N. Devine, Fred J. Fleitz, Brendan T. Grau, John Limanto, Christopher Savile, Emily Mundorff
  • Transaminase biocatalysts
    Patent number: 9353355
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: May 31, 2016
    Assignee: Codexis, Inc.
    Inventors: Christopher K. Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • TRANSAMINASE BIOCATALYSTS
    Publication number: 20150329838
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: August 5, 2015
    Publication date: November 19, 2015
    Inventors: Christopher K. Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • Transaminase biocatalysts
    Patent number: 9133445
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: September 15, 2015
    Assignee: Codexis, Inc.
    Inventors: Christopher K. Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • TRANSAMINASE REACTIONS
    Publication number: 20150079640
    Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventors: Gregory Hughes, Paul N. Devine, Fred J. Fleitz, Brendan T. Grau, John Limanto, Christopher Savile, Emily Mundorff
  • TRANSAMINASE BIOCATALYSTS
    Publication number: 20150037869
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 5, 2015
    Inventors: Christopher K. Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • Transaminase reactions
    Patent number: 8921079
    Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: December 30, 2014
    Assignee: Codexis, Inc.
    Inventors: Gregory Hughes, Paul N. Devine, Fred J. Fleitz, Brendan T. Grau, John Limanto, Christopher Savile, Emily Mundorff
  • Transaminase biocatalysts
    Patent number: 8889380
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: November 18, 2014
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, Emily Mundorff, Jeffrey Moore, Paul N. Devine, Jacob M. Janey
  • Transaminase Biocatalysts
    Publication number: 20120329108
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: September 5, 2012
    Publication date: December 27, 2012
    Applicant: CODEXIS, INC.
    Inventors: Christopher Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • Transaminase biocatalysts
    Patent number: 8293507
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: October 23, 2012
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • Transaminase Reactions
    Publication number: 20120190085
    Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
    Type: Application
    Filed: June 21, 2010
    Publication date: July 26, 2012
    Applicant: CODEXIS, INC.
    Inventors: Gregory Hughes, Paul N. Devine, Fred J. Fleitz, Brendan T. Grau, John Limanto, Christopher Savile, Emily Mundorff
  • Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine
    Patent number: 7923459
    Abstract: The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: April 12, 2011
    Assignee: NSAB, Filial AF Neurosearch Sweden AB, Sverige
    Inventors: Donald R. Gauthier, Richard Desmond, Paul N. Devine
  • TRANSAMINASE BIOCATALYSTS
    Publication number: 20100285541
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: February 26, 2010
    Publication date: November 11, 2010
    Applicant: CODEXIS, INC.
    Inventors: Christopher Saville, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • Diastereoselective reductive amination process
    Patent number: 7183425
    Abstract: This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with ?-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: February 27, 2007
    Assignee: Merck Frosst Canada Ltd.
    Inventors: Cheng Yi Chen, Paul N. Devine, Bruce S. Foster, Greg Hughes, Paul O'Shea
  • Process for preparing cis- aminochromanols
    Patent number: 6384244
    Abstract: cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: May 7, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Ian Davies, Karl Hansen, Paul N. Devine, Louis Matty, Jr., Yuan Cheng, Philippe M. Rabbat
  • Asymmetric conjugate addition reaction
    Patent number: 6353110
    Abstract: This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: March 5, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Paul N. Devine, Richard D. Tillyer, Richard M. Heid, Jr., David M. Tschaen
  • Process for preparing cis- aminochromanols
    Publication number: 20010056193
    Abstract: cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.
    Type: Application
    Filed: May 11, 2001
    Publication date: December 27, 2001
    Inventors: Ian Davies, Karl Hansen, Paul N. Devine, Louis Matty,Jr., Yuan Cheng, Philippe M. Rabbat
  • Enantioselective bioreduction using yeast
    Patent number: 6121026
    Abstract: The invention relates to a class of enantiomerically pure intermediates represented by Formula I, where X is F, Cl, Br, or I, and a novel enantioselective bioreductive process using yeast to form these intermediates, which are useful in the synthesis of endothelin antagonists, and the like.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: September 19, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Michel M. Chartrain, Barbara A. Krulewicz, Paul N. Devine, David M. Tschaen