Patents by Inventor Paul N. Devine

Paul N. Devine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxidation process using tempo
    Patent number: 6031101
    Abstract: The present invention relates to an oxidation using sodium chlorite in the presence of a catalytic amount of TEMPO and sodium hypochlorite which converts the penultimate intermediate bearing a primary alcohol to the target endothelin antagonist compound of Formula I having a carboxylic acid ##STR1##
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: February 29, 2000
    Assignees: Merck & Co., Inc., Banyu Pharmaceuticals Co., Ltd
    Inventors: Paul N. Devine, Eiichi Mano, Zhiguo Song, David M. Tschaen, Mangzu Zhao
  • Pyridine propanoic acid derivatives
    Patent number: 6022972
    Abstract: This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: February 8, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Paul N. Devine, Richard D. Tillyer, Richard M. Heid, Jr., David M. Tschaen
  • Stereoselective deoxygenation reaction
    Patent number: 5962688
    Abstract: This invention relates to a key intermediate in the synthesis of an endothelin antagonist, the synthesis of this key intermediate and the synthesis of an endothelin antagonist using this intermediate in a stereoselective deoxygenation reaction.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: October 5, 1999
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Paul N. Devine, Ulf H. Dolling, Lisa F. Frey, Richard D. Tillyer, David M. Tschaen, Yoshiaki Kato
  • Chiral auxilary for stereoselective alkylations
    Patent number: 5856519
    Abstract: This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the .alpha.-halo acid with an aryloxy group.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: January 5, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Paul N. Devine, Richard M. Heid, Jr., David M. Tschaen
  • Stereoselective process
    Patent number: 5708186
    Abstract: This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the .alpha.-halo acid with an aryloxy group.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: January 13, 1998
    Inventors: Paul N. Devine, David M. Tschaen, Richard M. Heid, Jr.
  • Process for the preparation of an endothelin antagonist
    Patent number: 5688974
    Abstract: The instant invention relates to a process for the stereoselective synthesis of a compounds of formula I: ##STR1##
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: November 18, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Paul N. Devine, David M. Tschaen