Abstract: Methods and devices for tissue fixation. A cortical button with a rib between two slotted openings. The rib increases the cortical button structural rigidity without increasing palpability. An adjustable loop construct with two discrete locking passages that provides manageable loop reduction and improved tissue coupling. The adjustable loop construct may be coupled to tissue via a passing construct. An assembly with a reduction bar, a button and an adjustable loop construct, the assembly provided assembled in a first configuration that disassembles to guide steps of tissue fixation. The reduction bar may be assembled to the reduction bar for reducing the adjustable loop construct.

Abstract: A three-part method of cleaning a user's teeth and/or gums is disclosed. First, a user applies a tonic of essential oils to the user's teeth and/or gums by either brushing, rubbing, rinsing and/or flossing with the tonic thereby destroying harmful bacteria. Second, the user brushes with a toothpaste having nano-hydroxyapatite being particles of 50 nanometers or smaller. The nano-hydroxyapatite is absorbed into the surface opening inside dentinal tubules of the teeth. Third, the user seeds their mouth with an oral probiotic having beneficial bacteria. The third step must come after both the first and second steps.

Abstract: Kits are provided for storing, transporting, and sterilizing reusable urinary catheters. A reusable urinary catheter stored within a housing of the kit may be sterilized between uses using a sterilization fluid or sterilizing light. If the reusable urinary catheter is sterilized using a sterilization fluid, the housing may include a manually actuated or electromechanical pump to circulate the sterilization fluid through the housing. The reusable urinary catheter may include a funnel secured to a catheter shaft, with a plurality of lateral openings defined in the funnel, which provide fluid communication between an interior of the funnel and an external surface of the catheter shaft. By allowing fluid communication between the interior of the funnel and the external surface of the catheter shaft, the lateral openings allow for fluid sterilization of both internal and external surfaces of the catheter shaft.

Abstract: A three-part method of cleaning a user's teeth and/or gums is disclosed. First, a user applies a tonic of essential oils to the user's teeth and/or gums by either brushing, rubbing, rinsing and/or flossing with the tonic thereby destroying harmful bacteria. Second, the user brushes with a toothpaste having nano-hydroxyapatite being particles of 50 nanometers or smaller. The nano-hydroxyapatite is absorbed into the surface opening inside dentinal tubules of the teeth. Third, the user seeds their mouth with an oral probiotic having beneficial bacteria. The third step must come after both the first and second steps.

Abstract: The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.

Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.

Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, R1, R4, R5, and R6 are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.

Abstract: A probiotic formulation includes the following: lactobacillus acidophilus comprising 15.0% to 40.0% per mass of the probiotic formulation; lactobacillus reuteri comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus salivarius comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus paracasei comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus thermophiles comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus salivarius BLIS K-12 comprising 5.0% to 30.0% per mass of the probiotic formulation; streptococcus salivarius BLIS M-18 comprising 5.0% to 30.0% per mass of the probiotic formulation; zinc oxide comprising 0.2% to 5.0% per mass of the probiotic formulation; hydroxyapatite comprising 0.1% to 25.0% per mass of the probiotic formulation; and dicalcium phosphate comprising 0.1% to 5.0% per mass of the probiotic formulation. The probiotic formulation may be formed into a lozenge or a gum.

Abstract: A two-part oral care system includes a plurality of micro-encapsulated vessels containing an oxidative composition inside a coating, the oxidative composition having a pH less than 7.5, and a reductant composition, the reductant composition having a pH greater than 7. The micro-encapsulated vessels isolate the oxidative and reductant compositions from reacting with one another during storage and wherein the micro-encapsulated vessels can dispense when ruptured the oxidative and reductant compositions for combining to result in a final composition for use. The oxidative composition includes an ozonated oil comprising 0.01% to 5.0% per mass of the final composition and an oxidant comprising 0.01% to 2.0% per mass of the final composition. The reductant composition may include an aloe gel, xylitol, a ferrous sulfate, a sodium bicarbonate, a calcium carbonate, a zinc gluconate, a salt, a bromelain, a papain, and at least one essential oil.

Abstract: A two-part oral care system includes a plurality of micro-encapsulated vessels containing an oxidative composition inside a coating, the oxidative composition having a pH less than 7.5, and a reductant composition, the reductant composition having a pH greater than 7. The micro-encapsulated vessels isolate the oxidative and reductant compositions from reacting with one another during storage and wherein the micro-encapsulated vessels can dispense when ruptured the oxidative and reductant compositions for combining to result in a final composition for use. The oxidative composition includes an ozonated oil comprising 0.01% to 5.0% per mass of the final composition and an oxidant comprising 0.01% to 2.0% per mass of the final composition. The reductant composition may include an aloe gel, xylitol, a ferrous sulfate, a sodium bicarbonate, a calcium carbonate, a zinc gluconate, a salt, a bromelain, a papain, and at least one essential oil.

Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: A probiotic formulation includes the following: lactobacillus acidophilus comprising 15.0% to 40.0% per mass of the probiotic formulation; lactobacillus reuteri comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus salivarius comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus paracasei comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus thermophiles comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus salivarius BLIS K-12 comprising 5.0% to 30.0% per mass of the probiotic formulation; streptococcus salivarius BLIS M-18 comprising 5.0% to 30.0% per mass of the probiotic formulation; zinc oxide comprising 0.2% to 5.0% per mass of the probiotic formulation; hydroxyapatite comprising 0.1% to 25.0% per mass of the probiotic formulation; and dicalcium phosphate comprising 0.1% to 5.0% per mass of the probiotic formulation. The probiotic formulation may be formed into a lozenge or a gum.

Abstract: Disclosed herein are compositions and methods of treating osteoporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: A two-part oral care system includes a first vessel containing an oxidative composition having a pH less than 7.5 and a second vessel containing a reductant composition having a pH greater than 7. The first and second vessels isolate the oxidative and reductant compositions from reacting with one another during storage and the vessels can dispense the oxidative and reductant compositions for combining to result in a final composition for use. The oxidative composition includes an ozonated oil and an oxidant. The reductant composition includes an aloe gel or aloe vera, a xylitol, a ferrous sulfate, a sodium bicarbonate, a calcium carbonate, a zinc gluconate, a salt comprising, a bromelain, a papain and at least one essential oil. A probiotic lozenge may also be used after the two-part oral care system to install good bacteria.

Abstract: The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.

Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.

Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, R1, R4, R5, and R6 are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.