Patents by Inventor Paul Patel

Paul Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240090755
    Abstract: A fluid management system includes a pump configured to pump fluid through the system at a fluid flow rate. The system includes a processor including a user interface, the user interface allowing a user to input a set of system operating parameters, the processor being configured to control the pump to maintain a target fluid flow rate based on the set of system operating parameters. The system further includes a scope device coupled to the pump to deliver fluid to a target surgical site, the scope device including an elongated shaft extending from a distal end thereof, the elongated shaft including at least one sensor, the sensor transmitting sensor data relating to target surgical site to the processor. The processor automatically signals to the pump to adjust the fluid flow rate based on the sensor data.
    Type: Application
    Filed: November 29, 2023
    Publication date: March 21, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Peter J. PEREIRA, Mayur Kiran PATEL, William STANHOPE, Eric WONG, Jozef SLANDA, Christopher P. GAUVIN, Chad SCHNEIDER, Brandon W. CRAFT, Kimberly DeGRAAF, Brian P. WATSCHKE, Timothy Paul HARRAH, Niraj Prasad RAUNIYAR, Sacha TANG
  • Publication number: 20240082242
    Abstract: The invention provides combination therapies that include CV-8972 and CV-8814. The combination therapies improve cardiac efficiency and thus are useful for treating cardiovascular conditions in a subject. The invention also provides methods of treating conditions using both CV-8972 and CV-8814 and pharmaceutical compositions that contain both CV-8972 and CV-8814.
    Type: Application
    Filed: January 5, 2022
    Publication date: March 14, 2024
    Inventors: Paul Chamberlin, Jaikrishna Patel
  • Publication number: 20240079955
    Abstract: A switched-capacitor DC-DC converter circuit may convert an input voltage into a desired output voltage level. A comparator may compare a desired voltage level to a divided version of the output voltage. A fully digital control circuit comprising a frequency divider circuit, a counter circuit, a digital control logic circuit and a gain selection circuit may generate a gain value, and a phase generator may convert the gain value into clock phase signals and control settings to control a switch array to select capacitors to produce a desired output voltage.
    Type: Application
    Filed: September 1, 2023
    Publication date: March 7, 2024
    Applicant: Microchip Technology Incorporated
    Inventors: Ajay Kumar, Paul Walker, Ibiyemi Omole, Daniel Meacham, Arvind Madan, Santosh Patel
  • Publication number: 20220137075
    Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.
    Type: Application
    Filed: September 9, 2021
    Publication date: May 5, 2022
    Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
  • Patent number: 11268130
    Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: March 8, 2022
    Assignee: Labrador Diagnostics LLC
    Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
  • Patent number: 11119110
    Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: September 14, 2021
    Assignee: Labrador Diagnotics LLC
    Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
  • Publication number: 20200166528
    Abstract: Methods for improving assays of biological samples are provided, including assays of small volume biological samples, such as blood samples obtained from a fingerstick. The methods include steps of selecting a baseline assay; providing a first revised assay by altering an aspect, a reagent, or a step of the baseline assay; comparing the results of the baseline assay and first revised assay; and identifying the first revised assay as an improved assay if the results of the first revised assay are similar to, are substantially the same as, or are better than, the results of the baseline assay. The methods may be iterated. Alterations include reducing sample volume; setting temperature; reducing step number and duration; altering reagent composition and number; and altering detection. Improved assays may reduce the duration, cost, or complexity of the assay, may improve assay sensitivity, accuracy, or reliability, and may provide synergistic improvements.
    Type: Application
    Filed: August 27, 2019
    Publication date: May 28, 2020
    Inventors: Paul Patel, Ian Gibbons, Elizabeth A. Holmes
  • Publication number: 20200063185
    Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 27, 2020
    Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
  • Publication number: 20190293665
    Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.
    Type: Application
    Filed: March 29, 2019
    Publication date: September 26, 2019
    Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes, Swapna Joshi
  • Patent number: 10422806
    Abstract: Methods for improving assays of biological samples are provided, including assays of small volume biological samples, such as blood samples obtained from a fingerstick. The methods include steps of selecting a baseline assay; providing a first revised assay by altering an aspect, a reagent, or a step of the baseline assay; comparing the results of the baseline assay and first revised assay; and identifying the first revised assay as an improved assay if the results of the first revised assay are similar to, are substantially the same as, or are better than, the results of the baseline assay. The methods may be iterated. Alterations include reducing sample volume; setting temperature; reducing step number and duration; altering reagent composition and number; and altering detection. Improved assays may reduce the duration, cost, or complexity of the assay, may improve assay sensitivity, accuracy, or reliability, and may provide synergistic improvements.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: September 24, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Paul Patel, Ian Gibbons, Elizabeth A. Holmes
  • Patent number: 10392650
    Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: August 27, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
  • Patent number: 10281479
    Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: May 7, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes, Swapna Joshi
  • Patent number: 9719990
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: August 1, 2017
    Assignee: Theranos, Inc.
    Inventors: Elizabeth A. Holmes, Ian Gibbons, Paul Patel, Samartha Anekal
  • Publication number: 20170175168
    Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.
    Type: Application
    Filed: November 30, 2016
    Publication date: June 22, 2017
    Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
  • Publication number: 20170038401
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Application
    Filed: May 23, 2016
    Publication date: February 9, 2017
    Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
  • Publication number: 20170023594
    Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.
    Type: Application
    Filed: May 27, 2016
    Publication date: January 26, 2017
    Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
  • Publication number: 20170023595
    Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.
    Type: Application
    Filed: June 10, 2016
    Publication date: January 26, 2017
    Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes
  • Patent number: 9546394
    Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: January 17, 2017
    Assignee: Theranos, Inc.
    Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
  • Patent number: 9538941
    Abstract: Systems and methods for the expression of bodily fluid from an incision in the skin include devices which bear against the skin in a manner to retain the fluid adjacent the incision site and urge the fluid inwardly toward the incision. Systems utilize a constricting member, a bi-stable expression member, or a pressing member. The present invention further encompasses combinations of the foregoing expression systems with each other, as well as with other expression devices known in the art. Moreover, the invention includes the combination of the expression systems with incising, sampling and/or testing systems, particularly in a single, integrated device. The present invention also contemplates the associated methods for expressing bodily fluid from an incision, including in combination with methods for incising, sampling and/or testing of the bodily fluid.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: January 10, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Edward Perez, Charles C. Raney, Paul Patel
  • Patent number: 9500639
    Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: November 22, 2016
    Assignee: Theranos, Inc.
    Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth Holmes