Patents by Inventor Paul Patel
Paul Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240090755Abstract: A fluid management system includes a pump configured to pump fluid through the system at a fluid flow rate. The system includes a processor including a user interface, the user interface allowing a user to input a set of system operating parameters, the processor being configured to control the pump to maintain a target fluid flow rate based on the set of system operating parameters. The system further includes a scope device coupled to the pump to deliver fluid to a target surgical site, the scope device including an elongated shaft extending from a distal end thereof, the elongated shaft including at least one sensor, the sensor transmitting sensor data relating to target surgical site to the processor. The processor automatically signals to the pump to adjust the fluid flow rate based on the sensor data.Type: ApplicationFiled: November 29, 2023Publication date: March 21, 2024Applicant: Boston Scientific Scimed, Inc.Inventors: Peter J. PEREIRA, Mayur Kiran PATEL, William STANHOPE, Eric WONG, Jozef SLANDA, Christopher P. GAUVIN, Chad SCHNEIDER, Brandon W. CRAFT, Kimberly DeGRAAF, Brian P. WATSCHKE, Timothy Paul HARRAH, Niraj Prasad RAUNIYAR, Sacha TANG
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Publication number: 20240082242Abstract: The invention provides combination therapies that include CV-8972 and CV-8814. The combination therapies improve cardiac efficiency and thus are useful for treating cardiovascular conditions in a subject. The invention also provides methods of treating conditions using both CV-8972 and CV-8814 and pharmaceutical compositions that contain both CV-8972 and CV-8814.Type: ApplicationFiled: January 5, 2022Publication date: March 14, 2024Inventors: Paul Chamberlin, Jaikrishna Patel
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Publication number: 20240079955Abstract: A switched-capacitor DC-DC converter circuit may convert an input voltage into a desired output voltage level. A comparator may compare a desired voltage level to a divided version of the output voltage. A fully digital control circuit comprising a frequency divider circuit, a counter circuit, a digital control logic circuit and a gain selection circuit may generate a gain value, and a phase generator may convert the gain value into clock phase signals and control settings to control a switch array to select capacitors to produce a desired output voltage.Type: ApplicationFiled: September 1, 2023Publication date: March 7, 2024Applicant: Microchip Technology IncorporatedInventors: Ajay Kumar, Paul Walker, Ibiyemi Omole, Daniel Meacham, Arvind Madan, Santosh Patel
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Publication number: 20220137075Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: ApplicationFiled: September 9, 2021Publication date: May 5, 2022Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
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Patent number: 11268130Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: GrantFiled: August 2, 2019Date of Patent: March 8, 2022Assignee: Labrador Diagnostics LLCInventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Patent number: 11119110Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: GrantFiled: January 16, 2015Date of Patent: September 14, 2021Assignee: Labrador Diagnotics LLCInventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
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Publication number: 20200166528Abstract: Methods for improving assays of biological samples are provided, including assays of small volume biological samples, such as blood samples obtained from a fingerstick. The methods include steps of selecting a baseline assay; providing a first revised assay by altering an aspect, a reagent, or a step of the baseline assay; comparing the results of the baseline assay and first revised assay; and identifying the first revised assay as an improved assay if the results of the first revised assay are similar to, are substantially the same as, or are better than, the results of the baseline assay. The methods may be iterated. Alterations include reducing sample volume; setting temperature; reducing step number and duration; altering reagent composition and number; and altering detection. Improved assays may reduce the duration, cost, or complexity of the assay, may improve assay sensitivity, accuracy, or reliability, and may provide synergistic improvements.Type: ApplicationFiled: August 27, 2019Publication date: May 28, 2020Inventors: Paul Patel, Ian Gibbons, Elizabeth A. Holmes
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Publication number: 20200063185Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: ApplicationFiled: August 2, 2019Publication date: February 27, 2020Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Publication number: 20190293665Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.Type: ApplicationFiled: March 29, 2019Publication date: September 26, 2019Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes, Swapna Joshi
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Patent number: 10422806Abstract: Methods for improving assays of biological samples are provided, including assays of small volume biological samples, such as blood samples obtained from a fingerstick. The methods include steps of selecting a baseline assay; providing a first revised assay by altering an aspect, a reagent, or a step of the baseline assay; comparing the results of the baseline assay and first revised assay; and identifying the first revised assay as an improved assay if the results of the first revised assay are similar to, are substantially the same as, or are better than, the results of the baseline assay. The methods may be iterated. Alterations include reducing sample volume; setting temperature; reducing step number and duration; altering reagent composition and number; and altering detection. Improved assays may reduce the duration, cost, or complexity of the assay, may improve assay sensitivity, accuracy, or reliability, and may provide synergistic improvements.Type: GrantFiled: July 25, 2014Date of Patent: September 24, 2019Assignee: Theranos IP Company, LLCInventors: Paul Patel, Ian Gibbons, Elizabeth A. Holmes
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Patent number: 10392650Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: GrantFiled: November 30, 2016Date of Patent: August 27, 2019Assignee: Theranos IP Company, LLCInventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Patent number: 10281479Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.Type: GrantFiled: January 16, 2015Date of Patent: May 7, 2019Assignee: Theranos IP Company, LLCInventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes, Swapna Joshi
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Patent number: 9719990Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: September 18, 2015Date of Patent: August 1, 2017Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Ian Gibbons, Paul Patel, Samartha Anekal
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Publication number: 20170175168Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: ApplicationFiled: November 30, 2016Publication date: June 22, 2017Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Publication number: 20170038401Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: May 23, 2016Publication date: February 9, 2017Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Publication number: 20170023594Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: ApplicationFiled: May 27, 2016Publication date: January 26, 2017Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
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Publication number: 20170023595Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.Type: ApplicationFiled: June 10, 2016Publication date: January 26, 2017Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes
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Patent number: 9546394Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: GrantFiled: January 23, 2015Date of Patent: January 17, 2017Assignee: Theranos, Inc.Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Patent number: 9538941Abstract: Systems and methods for the expression of bodily fluid from an incision in the skin include devices which bear against the skin in a manner to retain the fluid adjacent the incision site and urge the fluid inwardly toward the incision. Systems utilize a constricting member, a bi-stable expression member, or a pressing member. The present invention further encompasses combinations of the foregoing expression systems with each other, as well as with other expression devices known in the art. Moreover, the invention includes the combination of the expression systems with incising, sampling and/or testing systems, particularly in a single, integrated device. The present invention also contemplates the associated methods for expressing bodily fluid from an incision, including in combination with methods for incising, sampling and/or testing of the bodily fluid.Type: GrantFiled: June 10, 2010Date of Patent: January 10, 2017Assignee: Roche Diabetes Care, Inc.Inventors: Edward Perez, Charles C. Raney, Paul Patel
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Patent number: 9500639Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: GrantFiled: July 17, 2013Date of Patent: November 22, 2016Assignee: Theranos, Inc.Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth Holmes