Patents by Inventor Paul Patel
Paul Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9538941Abstract: Systems and methods for the expression of bodily fluid from an incision in the skin include devices which bear against the skin in a manner to retain the fluid adjacent the incision site and urge the fluid inwardly toward the incision. Systems utilize a constricting member, a bi-stable expression member, or a pressing member. The present invention further encompasses combinations of the foregoing expression systems with each other, as well as with other expression devices known in the art. Moreover, the invention includes the combination of the expression systems with incising, sampling and/or testing systems, particularly in a single, integrated device. The present invention also contemplates the associated methods for expressing bodily fluid from an incision, including in combination with methods for incising, sampling and/or testing of the bodily fluid.Type: GrantFiled: June 10, 2010Date of Patent: January 10, 2017Assignee: Roche Diabetes Care, Inc.Inventors: Edward Perez, Charles C. Raney, Paul Patel
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Patent number: 9500639Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: GrantFiled: July 17, 2013Date of Patent: November 22, 2016Assignee: Theranos, Inc.Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth Holmes
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Publication number: 20160320381Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: May 23, 2016Publication date: November 3, 2016Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Publication number: 20160266142Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.Type: ApplicationFiled: April 6, 2016Publication date: September 15, 2016Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes
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Patent number: 9389229Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.Type: GrantFiled: July 17, 2013Date of Patent: July 12, 2016Assignee: Theranos, Inc.Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes
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Publication number: 20160169923Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: December 10, 2015Publication date: June 16, 2016Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Patent number: 9326718Abstract: A system is proposed for detection of at least one analyte in a body fluid, in particular for detection of blood glucose. The system is designed to generate a sample of the body fluid and to transfer at least some of the sample to at least one test element, in particular a test panel. The system is designed such that a time period between the generation of the sample and the application to the test element is less than 1 second, preferably less than 500 ms.Type: GrantFiled: July 28, 2010Date of Patent: May 3, 2016Assignee: Roche Diabetes Care, Inc.Inventors: Wolfgang Petrich, Christian Vrancic, Daniel Wong, Paul Patel
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Publication number: 20160069919Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: August 13, 2015Publication date: March 10, 2016Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Gangakhedkar Surekha, Anekal Samartha, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Publication number: 20160033544Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: September 18, 2015Publication date: February 4, 2016Inventors: Elizabeth A. Holmes, Ian Gibbons, Paul Patel, Semartha Anekal
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Publication number: 20160024554Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: ApplicationFiled: January 23, 2015Publication date: January 28, 2016Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Publication number: 20150368717Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: July 1, 2015Publication date: December 24, 2015Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Publication number: 20150338428Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: July 1, 2015Publication date: November 26, 2015Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Patent number: 9186104Abstract: Instrument for producing a sample of body liquid for analysis by piercing the skin with a lancing element having a skin piercing tip. The instrument has a housing and a lancing drive for driving a lancing element connected thereto in a puncturing movement. A pressure ring surrounds a skin contact opening and is adapted for pressing against the skin such that the skin bulges into the opening for promoting expression of body fluid. The skin contact opening has an opening area corresponding to a circle with a diameter of at least 3 mm and at most 8 mm, and the instrument comprises a pressing force control device for controlling the pressing force between the pressure ring and the skin at the time of triggering the puncturing movement, to be at least 3 N and at most 8 N.Type: GrantFiled: April 29, 2013Date of Patent: November 17, 2015Assignee: Roche Diabetes Care, Inc.Inventors: Uwe Kraemer, Volker Zimmer, Wolfgang Roedel, Hans List, Stephan-Michael Frey, Christian Hoerauf, Paul Patel
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Publication number: 20150301018Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: ApplicationFiled: January 16, 2015Publication date: October 22, 2015Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth A. Holmes
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Publication number: 20150198591Abstract: Methods, compositions, systems, and devices are provided for performing and analyzing agglutination assays. In one aspect, methods for image analysis of agglutination assays are provided. In another aspects, methods for performing agglutination assays are provided. In one aspect, the methods may be used for the detection of various molecules, including viruses or antibodies against a virus. In another aspect, the methods can be used to determine effective immunization of a subject.Type: ApplicationFiled: January 16, 2015Publication date: July 16, 2015Inventors: Paul Patel, Samartha Anekal, Ian Gibbons, Elizabeth A. Holmes, Swapna Joshi
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Patent number: 9051599Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: GrantFiled: December 9, 2013Date of Patent: June 9, 2015Assignee: Theranos, Inc.Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Publication number: 20140308661Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: February 18, 2014Publication date: October 16, 2014Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Publication number: 20140296089Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: February 18, 2014Publication date: October 2, 2014Applicant: Theranos, Inc.Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Publication number: 20140170688Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: ApplicationFiled: December 9, 2013Publication date: June 19, 2014Applicant: Theranos, Inc.Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Publication number: 20140087403Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: ApplicationFiled: July 17, 2013Publication date: March 27, 2014Applicant: THERANOS, INC.Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth Holmes