Patents by Inventor Paul Polakis

Paul Polakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20140050744
    Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: July 18, 2013
    Publication date: February 20, 2014
    Inventors: Mark Dennis, William Mallet, Paul Polakis
  • Antibody-drug conjugates and methods
    Patent number: 8652479
    Abstract: The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p??I where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: February 18, 2014
    Assignee: Genentech, Inc.
    Inventors: Allen J. Ebens, Jr., Frederic S. Jacobson, Paul Polakis, Mark X. Sliwkowski, Susan D. Spencer
  • ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20140030280
    Abstract: The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 30, 2014
    Applicant: Genentech, Inc.
    Inventors: Paul Polakis, Andrew Polson, Susan Diane Spencer, Shang-Fan Yu
  • ANTI-CD22 ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20140030281
    Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 30, 2014
    Applicant: Genentech, Inc.
    Inventors: Paul Polakis, Andrew Polson, Susan Diane Spencer, Shang-Fan Yu, Bing Zheng
  • ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20140030282
    Abstract: The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 30, 2014
    Applicant: Genentech, Inc.
    Inventors: Paul Polakis, Andrew Polson, Susan Diane Spencer, Shang-Fan Yu, Bing Zheng
  • ANTI-CD22 ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20140030279
    Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 30, 2014
    Applicants: Spirogen Sarl, Genentech, Inc.
    Inventors: Paul Polakis, Andrew Polson, Susan Diane Spencer, Shang-Fan Yu, John A. Flygare, Janet L. Gunzner-Toste, Thomas Harden Pillow, Philip Wilson Howard, Luke Masterson
  • ANTI-LGR5 ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20130336885
    Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: March 29, 2013
    Publication date: December 19, 2013
    Applicant: GENENTECH INC.
    Inventors: Jo-Anne Hongo, Weiguang Mao, Paul Polakis, Andrew Polson, Rajesh Vij, Yan Wu, Wei-Ching Liang
  • ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR
    Publication number: 20130316402
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
    Type: Application
    Filed: February 13, 2013
    Publication date: November 28, 2013
    Applicant: GENENTECH, INC.
    Inventors: Mark S. Dennis, Bonnee Rubinfeld, Paul Polakis, Aya Jakobovits
  • ANTI-PMEL17 ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20130295007
    Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: April 30, 2013
    Publication date: November 7, 2013
    Applicant: GENENTECH, INC.
    Inventors: Youjun Chen, William Mallet, Paul Polakis, Christine Tan, Jyoti Asundi, Suzanna Clark
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8535675
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: September 17, 2013
    Assignee: Genentech, Inc.
    Inventors: Mark Dennis, Bonnee Rubinfeld, Paul Polakis
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8449883
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: May 28, 2013
    Assignee: Genentech, Inc.
    Inventors: Mark S. Dennis, William Mallet, Paul Polakis
  • Antibodies and immunoconjugates and uses therefor
    Patent number: 8436147
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: May 7, 2013
    Assignee: Genentech, Inc.
    Inventors: Mark S. Dennis, Bonnee Rubinfeld, Paul Polakis, Aya Jakobovits
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8398982
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. TAT113 polypeptides comprising the amino acid sequence of SEQ ID NO: 2 are disclosed. Antibodies that bind TAT113 polypeptides, including monoclonal, chimeric, humanized, single chain, and other antibodies, and fragments thereof, are disclosed. Methods of identifying antibodies that bind epitopes bound by such antibodies, including the antibodies produced by hybridoma cell lines disclosed in the application, are provided, wherein the ability of one antibody to block the binding of another antibody to a TAT113 polypeptide indicates that one antibody binds to an epitope bound by the other antibody.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: March 19, 2013
    Assignee: Genentech, Inc.
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Methods for the treatment of tumors expressing TAT123 or naturally occurring variants thereof
    Publication number: 20130064761
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: November 10, 2011
    Publication date: March 14, 2013
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
    Patent number: 8389697
    Abstract: The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: March 5, 2013
    Assignee: Genentech, Inc.
    Inventors: Italo Beria, Michele Caruso, John A. Flygare, Vittoria Lupi, Rita Perego, Paul Polakis, Andrew Polson, Matteo Salsa, Susan D. Spencer, Barbara Valsasina
  • PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
    Publication number: 20130028917
    Abstract: Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
    Type: Application
    Filed: April 15, 2011
    Publication date: January 31, 2013
    Applicant: SPIROGEN DEVELOPMENTS SÀRL
    Inventors: Philip Wilson Howard, Luke Masterson, Arnaud Tiberghien, John A. Flygare, Janet L. Gunzner, Paul Polakis, Andrew Polson, Helga E. Raab, Susan D. Spencer
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20130011402
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: April 13, 2009
    Publication date: January 10, 2013
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8278042
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: October 2, 2012
    Assignee: Genentech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • TUMOR TREATMENT
    Publication number: 20120201822
    Abstract: The invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of which is upregulated by the chemotherapeutic agent. The invention further concerns methods and means for the diagnosis and classification of tumors, and for the prognosis of the outcome of tumor treatment, and patient response to a particular treatment modality.
    Type: Application
    Filed: March 6, 2012
    Publication date: August 9, 2012
    Inventor: Paul Polakis
  • MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
    Publication number: 20120148610
    Abstract: Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 14, 2012
    Applicant: Seattle Genetics, Inc.
    Inventors: Svetlana O. Doronina, Peter D. Senter, Brian E. Toki, Allen J. Ebens, Toni Beth Kline, Paul Polakis, Mark X. Sliwkowski, Susan D. Spencer