Abstract: The present disclosure relates to a method for forming a catalyst article comprising: (a) forming a slurry having a solids content of up to 50 wt % by mixing together at least the following components a crystalline molecular sieve in an H+ or NH4+ form, an insoluble active metal precursor and an aqueous solvent at a temperature in the range 10 to 35° C.; (b) coating a substrate with the slurry formed in step (a); and (c) calcining the coated substrate formed in step (b) to form a catalyst layer on the substrate. The present disclosure further relates to a catalyst article, particularly a catalyst article which is suitable for use in the selective catalytic reduction of nitrogen oxides, and to an exhaust system.

Abstract: Various examples are provided related to mixed material magnetic cores, which can be utilized for shielding of eddy current induced excess losses. In one example, a magnetic core includes a ribbon core and leakage prevention or redirection shielding surrounding at least a portion of the ribbon core. The leakage prevention or redirection shielding can be positioned adjacent to the ribbon core and between the ribbon core and a magnetomotive force (MMF) source such as, e.g., a coil. The leakage prevention or redirection shielding extend beyond the ends of the MMF source and, in some implementations, can extend over the ends of the MMF source. In another example, a magnetic device can include a ribbon core, a MMF and leakage prevention or redirection shielding positioned between the MMF source and the ribbon core.

Abstract: A bioreactor comprising a housing defining a perfusion chamber, the housing including at least one port, wherein the at least one port is coupled to the housing, and a sample holder positioned within the perfusion chamber. A bioreactor and spheroid-based biofabrication method for making perfusible tissue constructs and perfusing them.

Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).

Abstract: Methods of characterizing an analyte using a detector such as a nanopore and an enzyme are provided. One aspect features methods for characterizing a double-stranded polynucleotide using a detector, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: An adapter assembly for connecting an end effector to an electrosurgical instrument is provided. The adapter assembly includes a drive transfer assembly, first and second pusher assemblies, a drive member, an extension assembly, and a trocar assembly. The drive transfer assembly includes first, second and third rotatable shafts. Each pusher assembly is operably connected to a rotatable shaft for converting rotational motion from one rotatable shaft to longitudinal movement to perform a different function. The drive member is operably connected to the third rotatable shaft for transferring rotational motion from the third rotatable shaft to perform a third function. The extension assembly is operably connected to a distal end of the adapter assembly and includes at least one flexible band assembly operably connected to one of the first and second pusher assemblies. The trocar assembly is configured for releasable engagement with the extension assembly.

Abstract: The present disclosure relates to a method for forming a catalyst article comprising: (a) forming a plastic mixture having a solids content of greater than 50% by weight by mixing together a crystalline small pore or medium pore molecular sieve in an H+ or NH4+ form, an insoluble active metal precursor, an inorganic matrix component, an organic auxiliary agent, an aqueous solvent and optionally inorganic fibres; (b) moulding the plastic mixture into a shaped article; and (c) calcining the shaped article to form a solid catalyst body. The present disclosure further relates to a catalyst article, particularly a catalyst article which is suitable for use in the selective catalytic reduction of nitrogen oxides, and to an exhaust system.

Abstract: An acid-generating fluid includes a thermally activated strong acid precursor. The thermally activated strong acid precursor can include a component selected from aldehydes, ketones, and combinations thereof, in combination with a precursor of a compound adapted to react to liberate sulfur dioxide; or it can include sulfur dioxide in combination with a precursor of a compound adapted to react to liberate a component selected from aldehydes, ketones, and combinations thereof.

Abstract: A processor-implemented method for the ownership transfer and tracking of tangible assets using a blockchain is described. In an embodiment, the method includes generating a root node associated with a tangible asset via a processor. The root node has a first hash value that represents a storage location of the root node, data associated with a tangible asset, and a second hash value that represents a storage location of the subsidiary node. The method also includes storing a hierarchical hash-linked tree structure in a non-transitory, processor-readable memory. The hierarchical hash-linked tree structure can include multiple nodes. The multiple nodes include the root node and the subsidiary node. The subsidiary node has the second hash value, and data associated with a tangible sub-asset of the tangible asset.

Abstract: A near-field probe (and associated method) compatible with near-infrared electromagnetic radiation and high temperature applications above 300° C. (or 500° C. in some applications) includes an optical waveguide and a photonic thermal emitting structure comprising a near-field thermally emissive material coupled to or part of the optical waveguide. The photonic thermal emitting structure is structured and configured to emit near-field energy responsive to at least one environmental parameter of interest, and the near-field probe is structured and configured to enable extraction of the near-field energy to a far-field by coupling the near-field energy into one or more guided modes of the optical waveguide.

Abstract: The present invention relates to bi-specific antigen binding molecules and associated fusion proteins and conjugates. In particular, the present invention relates to bi-specific antigen binding molecules with specificity for both receptor tyrosine kinase-like orphan receptor 1 (ROR1) and epidermal growth factor receptor (EGFR) and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: The present invention is directed to a racquet design with an inner and outer frame connected by an isolation system. Uniquely adapted to tennis racquets, the natural motion of the inner frame relative to the outer frame upon impact of the tennis ball on the inner frame will generate spin when the ball contacts the inner frame. The relationship between the inner frame, outer frame and isolation system can control the spin imparted to the ball for a given tennis swing. The tuning of the isolators relative to conventional racquet characteristics will increase the amount of ball spin caused by conventional racquets. The invention also increases the accuracy of the tennis ball's trajectory.

Abstract: One or more embodiments described herein disclose methods and systems that are directed at facilitating access to and retrieval of data concealed on a distributed ledger-based network (DLN) with the use of zero-knowledge proof (ZKP) techniques. The methods and systems allow for the encryption, using an encryption key, of data related to a transaction between participants of the DLN, the encryption of the encryption key using a public key of an auditor of the transaction, and the generation of a ZKP that the encryption key used to encrypt the data corresponds to the encryption key encrypted using the public key such that the encrypted encryption key and/or the encrypted data are available to the auditor after the ZKP is verified by a self-executing code segment of the DLN. The ZKP also includes a proof that the encrypted data includes the transaction data.

Abstract: An adapter assembly includes an elongated body, a switch, a sensor link, and an annular member. The elongated body includes a proximal portion configured to couple to a handle assembly and a distal portion configured to couple to a surgical loading unit. The switch is configured to be toggled in response to the surgical loading unit being coupled to the distal portion of the adapter assembly. The sensor link is disposed within the distal portion of the adapter assembly and biased toward a distal position. The sensor link is longitudinally movable between a proximal position and the distal position. The annular member is disposed within the distal portion and is rotatable between a first orientation, in which the annular member prevents distal movement of the sensor link, and a second orientation, in which the sensor link moves distally to toggle the switch.

Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).

Abstract: A method of preparing a catalyst composition for producing a stable ratio of NO2 to NO in an exhaust system of a compression ignition engine is described. The method comprises: (i) preparing a first composition comprising a platinum (Pt) compound disposed or supported on a support material; (ii) preparing a second composition by reducing the platinum (Pt) compound to platinum (Pt) with a reducing agent; and (iii) heating the second composition to at least 650° C.

Abstract: An adapter assembly for connecting an end effector to an electrosurgical instrument is provided. The adapter assembly includes a drive transfer assembly, first and second pusher assemblies, a drive member, an extension assembly, and a trocar assembly. The drive transfer assembly includes first, second and third rotatable shafts. Each pusher assembly is operably connected to a rotatable shaft for converting rotational motion from one rotatable shaft to longitudinal movement to perform a different function. The drive member is operably connected to the third rotatable shaft for transferring rotational motion from the third rotatable shaft to perform a third function. The extension assembly is operably connected to a distal end of the adapter assembly and includes at least one flexible band assembly operably connected to one of the first and second pusher assemblies. The trocar assembly is configured for releasable engagement with the extension assembly.

Abstract: Disclosed are syringes that allow one-handed operation for measuring and dispensing a medicament, provide consistent finger placement on the syringe barrel. The syringes have a generally oval exterior shape that comfortably fits a user's hand and prevents rolling of the syringe when placed on a surface. Due to the shape of the syringes, the dispensing tip will not touch a surface or substrate when the syringe is placed thereon, providing improved hygiene and reduced contamination. The syringes preferably have a dosage marking on the barrel that provides ease of seeing the withdrawn medicament. The dosage marking can be raised and/or colored and/or made light sensitive. The raised markings can provide an audible and/or tactile indication of the dose of medicament drawn into or out of the syringe.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.