Abstract: This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists or partial agonists.

Abstract: An acid-generating fluid includes a thermally activated strong acid precursor. The thermally activated strong acid precursor can include a component selected from aldehydes, ketones, and combinations thereof, in combination with a precursor of a compound adapted to react to liberate sulfur dioxide; or it can include sulfur dioxide in combination with a precursor of a compound adapted to react to liberate a component selected from aldehydes, ketones, and combinations thereof.

Abstract: A fluid ejection device includes a fluid slot, at least one fluid ejection chamber communicated with the fluid slot, a drop ejecting element within the at least one fluid ejection chamber, a fluid circulation channel communicated with the fluid slot and the at least one fluid ejection chamber, and a fluid circulating element communicated with the fluid circulation channel. The fluid circulating element is to provide on-demand circulation of fluid from the fluid slot through the fluid circulation channel and the at least one fluid ejection chamber.

Abstract: A drug delivery device for administering a drug is presented having a body adapted to retain a cartridge containing a drug, at least one electrical unit and a port for electrically contacting the electrical unit, an adapter for attaching an injection needle to the drug delivery device, a safety mechanism arranged to prevent contacting the electrical unit through the port whilst an injection needle is in fluid communication with the cartridge and arranged to prevent establishing a fluid communication between an injection needle and the cartridge whilst the port is configured to allow contacting the electrical unit.

Abstract: A patient rotation system for rotating the body of a patient comprises an air inflatable cushion having two elastic exterior surfaces, e.g. of stretch material, wherein one of said two elastic surfaces of said cushion forms the top surface, and the other one forms the bottom surface. In deflated state the cushion has a flat shape and in inflated state the two elastic surfaces bulge away from each other, such that inflation of the cushion causes the cushion to assume a wedge shape thereby rotating the body around said rotation axis. The cushion is embodied as a unitary, semi-rigid, portable board when in its deflated state, which enables the sliding of the deflated cushion in between the body of the patient and a horizontal surface, on which the body is lying in supine position, until its posterior support points are being supported by the cushion at its top elastic surface.

Abstract: The present disclosure relates to adapter assemblies for use with and to electrically and mechanically interconnect electromechanical surgical devices and surgical reloads, and to surgical systems including handheld electromechanical surgical devices and adapter assemblies for connecting surgical reloads to the handheld electromechanical surgical devices.

Abstract: Methods for production of ethanol, distiller's corn oil, and enhanced co-products are disclosed. Methods include obtaining a mixture of one or more co-products of an alcohol production process, which may include wet cake, performing hydrolysis of polysaccharides in the mixture to generate fermentable sugars, fermenting the fermentable sugars in the mixture to produce alcohol, distilling the mixture to remove alcohol from the mixture thereby producing alcohol-containing distillate and enhanced whole stillage, removing released oil from the fermented mixture before distillation and/or from the enhanced whole stillage after distillation, and recovering enhanced wet distiller's grains, enhanced thin stillage, and/or enhanced dried distiller's grains. Compositions disclosed herein include enhanced dried distiller's grains having a cmde protein content of at least 45% on a dry weight basis and having a total fat content of less than 10% on a dry weight basis.

Abstract: A processor-implemented method for the ownership transfer and tracking of tangible assets using a blockchain is described. In an embodiment, the method includes generating a root node associated with a tangible asset via a processor. The root node has a first hash value that represents a storage location of the root node, data associated with a tangible asset, and a second hash value that represents a storage location of the subsidiary node. The method also includes storing a hierarchical hash-linked tree structure in a non-transitory, processor-readable memory. The hierarchical hash-linked tree structure can include multiple nodes. The multiple nodes include the root node and the subsidiary node. The subsidiary node has the second hash value, and data associated with a tangible sub-asset of the tangible asset.

Abstract: A booster explosive (10) comprises a canister body 12 within which is a cap well (20) having disposed therein a detonator (24). A protective sleeve (28) encloses the cap well (20) except for that portion of the cap well, the active portion (20d), which encloses the explosive end section (24a) of detonator (24). The protective sleeve serves to attenuate the force of shock waves from nearby prior explosions acting on the detonator (24). An annular air space (32) may be provided between protective sleeve (28) and cap well (20) to further attenuate the force of such shock waves. Attenuation of the shock waves reduces the likelihood of damage to detonators (24) by prior nearby explosions.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: The present disclosure relates to a method for forming a catalyst article comprising: (a) forming a slurry having a solids content of up to 50 wt % by mixing together at least the following components a crystalline molecular sieve in an H+ or NH4+ form, an insoluble active metal precursor and an aqueous solvent at a temperature in the range 10 to 35° C.; (b) coating a substrate with the slurry formed in step (a); and (c) calcining the coated substrate formed in step (b) to form a catalyst layer on the substrate. The present disclosure further relates to a catalyst article, particularly a catalyst article which is suitable for use in the selective catalytic reduction of nitrogen oxides, and to an exhaust system.

Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).

Abstract: Various examples are provided related to mixed material magnetic cores, which can be utilized for shielding of eddy current induced excess losses. In one example, a magnetic core includes a ribbon core and leakage prevention or redirection shielding surrounding at least a portion of the ribbon core. The leakage prevention or redirection shielding can be positioned adjacent to the ribbon core and between the ribbon core and a magnetomotive force (MMF) source such as, e.g., a coil. The leakage prevention or redirection shielding extend beyond the ends of the MMF source and, in some implementations, can extend over the ends of the MMF source. In another example, a magnetic device can include a ribbon core, a MMF and leakage prevention or redirection shielding positioned between the MMF source and the ribbon core.

Abstract: A bioreactor comprising a housing defining a perfusion chamber, the housing including at least one port, wherein the at least one port is coupled to the housing, and a sample holder positioned within the perfusion chamber. A bioreactor and spheroid-based biofabrication method for making perfusible tissue constructs and perfusing them.

Abstract: An adapter assembly for connecting an end effector to an electrosurgical instrument is provided. The adapter assembly includes a drive transfer assembly, first and second pusher assemblies, a drive member, an extension assembly, and a trocar assembly. The drive transfer assembly includes first, second and third rotatable shafts. Each pusher assembly is operably connected to a rotatable shaft for converting rotational motion from one rotatable shaft to longitudinal movement to perform a different function. The drive member is operably connected to the third rotatable shaft for transferring rotational motion from the third rotatable shaft to perform a third function. The extension assembly is operably connected to a distal end of the adapter assembly and includes at least one flexible band assembly operably connected to one of the first and second pusher assemblies. The trocar assembly is configured for releasable engagement with the extension assembly.

Abstract: Methods of characterizing an analyte using a detector such as a nanopore and an enzyme are provided. One aspect features methods for characterizing a double-stranded polynucleotide using a detector, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: The present disclosure relates to a method for forming a catalyst article comprising: (a) forming a plastic mixture having a solids content of greater than 50% by weight by mixing together a crystalline small pore or medium pore molecular sieve in an H+ or NH4+ form, an insoluble active metal precursor, an inorganic matrix component, an organic auxiliary agent, an aqueous solvent and optionally inorganic fibres; (b) moulding the plastic mixture into a shaped article; and (c) calcining the shaped article to form a solid catalyst body. The present disclosure further relates to a catalyst article, particularly a catalyst article which is suitable for use in the selective catalytic reduction of nitrogen oxides, and to an exhaust system.

Abstract: An acid-generating fluid includes a thermally activated strong acid precursor. The thermally activated strong acid precursor can include a component selected from aldehydes, ketones, and combinations thereof, in combination with a precursor of a compound adapted to react to liberate sulfur dioxide; or it can include sulfur dioxide in combination with a precursor of a compound adapted to react to liberate a component selected from aldehydes, ketones, and combinations thereof.

Abstract: A processor-implemented method for the ownership transfer and tracking of tangible assets using a blockchain is described. In an embodiment, the method includes generating a root node associated with a tangible asset via a processor. The root node has a first hash value that represents a storage location of the root node, data associated with a tangible asset, and a second hash value that represents a storage location of the subsidiary node. The method also includes storing a hierarchical hash-linked tree structure in a non-transitory, processor-readable memory. The hierarchical hash-linked tree structure can include multiple nodes. The multiple nodes include the root node and the subsidiary node. The subsidiary node has the second hash value, and data associated with a tangible sub-asset of the tangible asset.

Abstract: A near-field probe (and associated method) compatible with near-infrared electromagnetic radiation and high temperature applications above 300° C. (or 500° C. in some applications) includes an optical waveguide and a photonic thermal emitting structure comprising a near-field thermally emissive material coupled to or part of the optical waveguide. The photonic thermal emitting structure is structured and configured to emit near-field energy responsive to at least one environmental parameter of interest, and the near-field probe is structured and configured to enable extraction of the near-field energy to a far-field by coupling the near-field energy into one or more guided modes of the optical waveguide.