Patents by Inventor Paul S. Weiss

Paul S. Weiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190187040
    Abstract: Systems and methods of fabricating and functionalizing patterned nanowire probes that are stable under fluid reservoir conditions and have imageable patterns are provided. Additional embodiments possess functionalized molecular groups to collect content data of desired chemical species from a fluid reservoir in order to detect even highly dilute quantities of the desire chemical species in the reservoir. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Applicant: The Regents of the University of California
    Inventors: Paul S. Weiss, Anne M. Andrews, Andrea L. Bertozzi, Stanley J. Osher
  • Publication number: 20190177677
    Abstract: A microfluidic device for processing cells for the intracellular delivery of molecules or other cargo includes a plurality of microchannels disposed in a substrate or chip and fluidically coupled to an inlet configured to receive a solution containing the cells and the molecules or other cargo to be delivered intracellularly to the cells. Each of the plurality of microchannels has one or more constriction regions therein, wherein the constriction regions comprise an omniphobic, superhydrophilic, or superhydrophobic surface. In some embodiments, multiple microfluidic devices operating in parallel are used to process large numbers of cells. The device and method has particularly applicability to delivering gene-editing molecules intracellularly to cells.
    Type: Application
    Filed: August 19, 2017
    Publication date: June 13, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, BRIGHAM AND WOMEN'S HOSPITAL
    Inventors: Steven J. Jonas, Paul S. Weiss, Xu Hou, Joanna Aizenberg, Alireza Khademhosseini
  • Patent number: 9630161
    Abstract: Methods and assemblies for the construction of liquid-phase alloy nanoparticles are presented. Particle formation is directed by molecular self-assembly and assisted by sonication. In some embodiments, eutectic gallium-indium (EGaIn) nanoparticles are formed. In these embodiments, the bulk liquid alloy is ultrasonically dispersed, fast thiolate self-assembly at the EGaIn interface protects the material against oxidation. The assembly shell has been designed to include intermolecular hydrogen bonds, which induce surface strain, assisting in cleavage of the alloy particles to the nanoscale. X-ray diffraction and TEM analyses reveal that the nanoscale particles are in an amorphous or liquid phase, with no observed faceting.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: April 25, 2017
    Assignee: The Regents of the University of California
    Inventors: James Nathan Hohman, Paul S. Weiss
  • Publication number: 20170052104
    Abstract: Systems and methods of fabricating and functionality patterned nanowire probes that are stable under fluid reservoir conditions and have imageable contrast are provided. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.
    Type: Application
    Filed: May 5, 2015
    Publication date: February 23, 2017
    Applicant: The Regents of the University of California
    Inventors: Paul S. Weiss, Anne M. Andrews, Andrea L. Bertozzi, Stanley J. Osher
  • Publication number: 20150328616
    Abstract: Surface mediated polymer synthesizing methods and related systems and materials are described where monomers are attached to monomer binding regions on a surface and subsequently form chemical bonds with adjacent monomers on the surface to form linear polymers selected from polynucleotide, polypeptides and polysaccharides.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 19, 2015
    Inventors: Matthew GETHERS, William A. GODDARD, III, Paul S WEISS, John RANDALL
  • Publication number: 20130244037
    Abstract: Methods and assemblies for the construction of liquid-phase alloy nanoparticles are presented. Particle formation is directed by molecular self-assembly and assisted by sonication. In some embodiments, eutectic gallium-indium (EGaIn) nanoparticles are formed. In these embodiments, the bulk liquid alloy is ultrasonically dispersed, fast thiolate self-assembly at the EGaIn interface protects the material against oxidation. The assembly shell has been designed to include intermolecular hydrogen bonds, which induce surface strain, assisting in cleavage of the alloy particles to the nanoscale. X-ray diffraction and TEM analyses reveal that the nanoscale particles are in an amorphous or liquid phase, with no observed faceting.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 19, 2013
    Applicant: The Regents of the University of California
    Inventors: James Nathan Hohman, Paul S. Weiss
  • Patent number: 7015062
    Abstract: The present invention is a method and apparatus relating to manufacturing nanostructure patterns and components using molecular science. The method includes overlaying a multilayer organic molecule resist on at least a portion of a parent structure selectively deposited on a substrate, depositing a layer over the parent structure and in contact with at least a portion of the multilayer organic resist, and removing the multilayer organic molecule resist to leave a residual structure.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: March 21, 2006
    Assignee: The Penn State Research Foundation
    Inventors: Paul S. Weiss, Anat Hatzor
  • Patent number: 6835534
    Abstract: The present invention discloses devices and methods relating to patterning substrates using chemical functionalization. The methods include covering the surface of a substrate with a first plurality of molecules, selecting at least one internal bond from the plurality of molecules, and reacting the at least one internal bond to form at least one second functional group. Either or both of the functional groups can then be further reacted.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 28, 2004
    Assignee: The Penn State Research Foundation
    Inventors: Paul S. Weiss, Ray L. Funk
  • Patent number: 6597194
    Abstract: A tunable high frequency AC scanning tunneling microscope (ACSTM) has been utilized to image and to record spectra for semiconductor characterization. A difference frequency mixing technique sensitive to dopant type and concentration is applied both to uniformly doped and to patterned semiconductor substrates. Uniformly doped silicon substrates were used to characterize the difference frequency spectral signature for both p- and n-type Si. Comparison of the measured difference frequency to such signature can be used for distinguishing between the two types of dopants in samples with unknown dopant type. Patterned substrates were then fabricated, and a spectroscopic imaging mode was used to map out dopant density at ultrahigh resolution, and to distinguish between areas of different concentration and different dopant type.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: July 22, 2003
    Assignees: The Penn State Research Foundation, Atolytics, Inc.
    Inventors: Paul S. Weiss, Gregory S. McCarty
  • Publication number: 20020127491
    Abstract: The present invention discloses devices and methods relating to patterning substrates using chemical functionalization. The methods include covering the surface of a substrate with a first plurality of molecules, selecting at least one internal bond from the plurality of molecules, and reacting the at least one internal bond to form at least one second functional group. Either or both of the functional groups can then be further reacted.
    Type: Application
    Filed: October 26, 2001
    Publication date: September 12, 2002
    Inventors: Paul S. Weiss, Ray L. Funk
  • Patent number: 6430511
    Abstract: A molecular computer is formed by establishing arrays of spaced-apart input and output pins on opposing sides of a containment, injecting moleware in solution into the containment and then allowing the moleware to bridge the input and output pins. Moleware includes molecular alligator clip-bearing 2-, 3-, and molecular 4-, or multi-terminal wires, carbon nanotube wires, molecular resonant tunneling diodes, molecular switches, molecular controllers that can be modulated via external electrical or magnetic fields, massive interconnect stations based on single nanometer-sized particles, and dynamic and static random access memory (DRAM and SRAM) components composed of molecular controller/nanoparticle or fullerene hybrids. The current-voltage characteristics that result from the bridging between input and output arrays can be ascertained using another computer to identify the bundles of inputs and corresponding outputs that provide a truth table for the specific functions of the computer.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: August 6, 2002
    Assignee: University of South Carolina
    Inventors: James M Tour, Mark A Reed, Jorge M Seminario, David L Allara, Paul S Weiss
  • Publication number: 20020033708
    Abstract: A tunable high frequency AC scanning tunneling microscope (ACSTM) has been utilized to image and to record spectra for semiconductor characterization. A difference frequency mixing technique sensitive to dopant type and concentration is applied both to uniformly doped and to patterned semiconductor substrates. Uniformly doped silicon substrates were used to characterize the difference frequency spectral signature for both p- and n-type Si. Comparison of the measured difference frequency to such signature can be used for distinguishing between the two types of dopants in samples with unknown dopant type. Patterned substrates were then fabricated, and a spectroscopic imaging mode was used to map out dopant density at ultrahigh resolution, and to distinguish between areas of different concentration and different dopant type.
    Type: Application
    Filed: June 15, 2001
    Publication date: March 21, 2002
    Inventors: Paul S. Weiss, Gregory S. McCarty
  • Patent number: 5858666
    Abstract: A transducer for detecting biomolecules comprises a bottom and a top unit. The bottom unit has a set of parallel electrically conductive transmission lines thereon and probes attached to selected locations along each transmission line for binding with the target molecule. The top unit has thereon a second set of parallel transmission lines transverse to those on the bottom unit. By applying AC signals sequentially to the two sets of transmission lines, each of the probe locations at the intersection of the two transmission lines can be addressed and the response of the probe in an unfilled detector location or a complex formed by the probe and the target in a filled detector location can be measured. If the target has been labelled, than the label at each of the locations may also be detected. The device can also be used for measuring binding constants between the probe and the target and concentrations of target solutions.
    Type: Grant
    Filed: August 29, 1996
    Date of Patent: January 12, 1999
    Assignees: Biotechnology Research and Development Corporation, The Penn State Research Foundation
    Inventor: Paul S. Weiss
  • Patent number: 5661301
    Abstract: In spectroscopic mode, the energy levels of an atom, molecule or surface feature are determined by scanning laser frequencies and/or microwave frequencies. Enhanced radiation in the microwave or optical frequency range is detected and the detected spectra characterize the energy levels. In the analytical mode, the laser and/or microwave frequencies are optimized to detect the presence of an atom, molecule or surface feature.
    Type: Grant
    Filed: February 7, 1996
    Date of Patent: August 26, 1997
    Assignee: The Penn State Research Foundation
    Inventor: Paul S. Weiss
  • Patent number: 5619035
    Abstract: A system for transporting in a vacuum chamber sample holders and samples between a holder tray and a location for use with a surface analytical instrument is disclosed. Also provided is a system including a microwave coaxial cable connecting the tip terminal of a scanning tunneling microscope to a microwave signal source and a system for clamping a heater to a sample holder in order to heat the sample.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: April 8, 1997
    Assignees: Biotechnology Research & Development Corporation, Penn State Research Foundation
    Inventors: Paul S. Weiss, Stephan J. Stranick
  • Patent number: 5581193
    Abstract: Multiple frequency sources are used to apply a time varying signal to a scanning tunneling microscope and a current or voltage passing between the electrodes of the microscope is measured by a microwave spectrum/network analyzer which detects simultaneously at the multiple input frequencies and combinations thereof. This permits multiple substances to be monitored simultaneously. By choosing appropriate frequencies of input signals to be mixed or combined before application to the sample, it is possible to measure at a difference frequency which may improve signal to noise ratio and possible to match generating and reaction potentials and relaxation times to render detection possible. When applied to an array of Coulomb blockade devices used as a current standard, accuracy of the standard can be tested and the signal-to-noise ratio can be improved in the measurements, or the thresholds of the devices can be detected.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: December 3, 1996
    Assignees: Penn State Research Foundation, Biotechnology Research and Development Corporation
    Inventors: Paul S. Weiss, Stephan J. Stranick
  • Patent number: 5559328
    Abstract: A sample and the tip portion of an alternating current scanning tunneling microscope are electrically enclosed within a cavity with electrically conductive walls. The dimensions of the cavity are smaller than the wavelength of a component of the AC signal applied by the probe to the sample so that the output signal detected by the probe from the sample will not be contaminated by resonant effects of the cavity.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: September 24, 1996
    Assignee: Biotechnology Research and Development Corporation
    Inventors: Paul S. Weiss, Lloyd A. Bumm, Barry G. Willis, Richard L. Baer
  • Patent number: 5504366
    Abstract: A system for transporting in a vacuum chamber sample holders and samples between a holder tray and a location for use with a surface analytical instrument is disclosed. Also provided is a system including a microwave coaxial cable connecting the tip terminal of a scanning tunneling microscope to a microwave signal source and a system for clamping a heater to a sample holder in order to heat the sample.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: April 2, 1996
    Assignees: Biotechnology Research and Development Corp., Penn State Research Foundation
    Inventors: Paul S. Weiss, Stephan J. Stranick
  • Patent number: 5434842
    Abstract: By applying a voltage or signal and withdrawing or injecting an electron or electrons to a layer of material, it is possible to write, erase or read data electrochemically. The layer of material has at least one portion that will reversibly change between charge states in response to the applied voltage or signal and the withdrawal or injection of an electron or electrons. Alternatively, the material of the layer may be such that the portion of the layer of material will dissociate into components in response to the applied voltage or signal and injection or withdrawal of an electron or electrons. The stored data may be read using a scanning tunneling microscope by applying a voltage or signal thereto and detecting the current through, voltage across or signal reflected from the layer to detect the different charge states or structures of different portions of the layer. The signal or voltage applied can be a DC or AC signal, a signal pulse or transient or various combinations thereof.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: July 18, 1995
    Assignees: Biotechnology Research and Development Corporation, The Penn State Research Foundation
    Inventors: Paul S. Weiss, Stephan J. Stranick
  • Patent number: 5281814
    Abstract: A microwave sweep oscillator is used to apply an AC signal from the probe tip of a scanning tunneling microscope to a sample, and the reflected signal from the sample is measured by a microwave spectrum/network analyzer, or another device capable of measuring amplitude versus frequency. The frequency of the signal applied by the oscillator may be swept across a spectrum and the optimum frequency of the spectrum is determined so that an improved image of the surface of a sample may be obtained. The spectrum of a known substance may also be recorded and used as a signature for identifying components of an unknown substance by comparison. When the amplitude of the AC signal applied is increased, a sudden change in the reThis invention was made with support from the National Science Foundation, United States Government, under Grant No. CHE-9158375. The government has rights in this invention.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: January 25, 1994
    Assignee: The Penn State Research Foundation, Penn State Rsrch Foundtn & Biotechnol. Rsch. & Dev. Corp.
    Inventors: Paul S. Weiss, Stephan J. Stranick