Abstract: Novel Process and Intermediates. A process for preparing a compound of formula (I) where R4 and R5 are as defined in the specification; and R6 is hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R4 and R5 and R6 are as defined in relation to formula (I), and R7 is nitrogen protecting group, and removing the group R7, and thereafter if desired, removing any protecting group R6. Novel intermediates and the use of these in the formation of pharmaceutical compounds is also described and claimed.

Abstract: A scroll compressor which comprises a scroll assembly comprising two scroll walls, and a drive for causing a relative orbiting motion between the scroll walls for compressing fluid on two fluid flow paths between an inlet and an exhaust of the scroll assembly. A first fluid flow path is formed between a wall surfaces of the scroll walls and a second fluid flow path is formed between another facing wall surfaces of the scroll walls. A first ambient clearance A1 is selected between the first two facing surfaces, and a second ambient clearance A2 is selected between the second two facing surfaces, and where the first and the second ambient clearances are selected independently from each other. Independent selection permits each ambient clearance to be designed according to its own performance requirements, to take into account thermal expansion and manufacturing tolerances.

Abstract: A scroll compressor which comprises a scroll assembly comprising two scroll walls, and a drive for causing a relative orbiting motion between the scroll walls for compressing fluid on two fluid flow paths between an inlet and an exhaust of the scroll assembly. A first fluid flow path is formed between a wall surfaces of the scroll walls and a second fluid flow path is formed between another facing wall surfaces of the scroll walls. A first ambient clearance A1 is selected between the first two facing surfaces, and a second ambient clearance A2 is selected between the second two facing surfaces, and where the first and the second ambient clearances are selected independently from each other. Independent selection permits each ambient clearance to be designed according to its own performance requirements, to take into account thermal expansion and manufacturing tolerances.

Abstract: Compounds of formula (I): are described wherein R1-R6 and m are as defined within. Processes for their preparation and their use as NPY 5 inhibitors is described.

Abstract: A compound vacuum pump includes a regenerative section and a Holweck section. An annular abutment is formed on the radially innermost rotating cylinder of the Holweck section. The abutment acts to cause dust and foreign particles entering an inlet of the pump to be trapped before entering an inlet of the regenerative section. A circular barrier may be used with the abutment to assist with trapping the dust and foreign particles.

Abstract: A screw pump has two parallel shafts mounted in a pump body, each shaft thereon and each rotor has at least one helical vane or thread. When the helical vanes or threads inter mesh causing a fluid to be pumped from an inlet towards an outlet of the pump. The bearings associated with each shaft are being positioned in cavities within the first and second rotors which are sealed at their ends closest to the pump inlet. A thermal shield is provided between the bearing arrangements and the internal cavity surfaces.

Abstract: A screw pump has two parallel shafts mounted in a pump body, each shaft thereon and each rotor has at least one helical vane or thread. When the helical vanes or threads intermesh causing a fluid to be pumped from an inlet towards an outlet of the pump. The bearings associated with each shaft are being positioned in cavities within the first and second rotors which are sealed at their ends closest to the pump inlet. A thermal shield is provided between the bearing arrangements and the internal cavity surfaces.

Abstract: A compound vacuum pump includes a pump body divided by a partition into upper and lower chambers. A screw pump section occupies the lower chamber and a Roots-type pump section occupies the upper chamber. The Roots-type pump section comprises two rotors each with a disc for rotation in a bore of the partition.

Abstract: A compound vacuum pump includes a regenerative section and a Holweck section. An annular abutment is formed on the radially innermost rotating cylinder of the Holweck section. The abutment acts to cause dust and foreign particles entering an inlet of the pump to be trapped before entering an inlet of the regenerative section. A circular barrier may be used with the abutment to assist with trapping the dust and foreign particles.

Abstract: A compound vacuum pump includes a pump body divided by a partition into upper and lower chambers. A screw pump section occupies the lower chamber and a Roots-type pump section occupies the upper chamber. The Roots-type pump section comprises two rotors each with a disc for rotation in a bore of the partition.

Abstract: A temperature control system for a vacuum pump comprising means through which can flow a temperature control fluid, and a thermal resistor located between said means and a surface of the vacuum pump whose temperature is to be controlled.

Abstract: A vacuum pump comprising a pump chamber having an inlet and an outlet and through which gas from an enclosure connectable to the inlet can be pumped to a pump exhaust. At least one rotor, adapted for high velocity rotation, is provided within the chamber and mounted on a shaft extending from the chamber and to a pump gearbox substantially isolated from the chamber by means of a shaft seal associated with the shaft. The shaft seal is of a close tolerance but non-contact design. During use of the pump, gas pressure in the vicinity of the shaft seals and arising from the changeable gas pressures associated with operation of the pump rotor is buffered.

Abstract: A screw pump provided with a first shaft and spaced therefrom and parallel thereto a second shaft mounted in a pump body. A first rotor is mounted on the first shaft and a second rotor mounted on the second shaft. Each of the first and second rotors having formed on an outer surface thereof one or more one helical vanes or threads intermeshing together so that rotary movement of the shafts will cause a fluid to be pumped. A first bearing arrangement is associated with the first shaft and a second bearing arrangement is associated with the second shaft. A bearing carrier is provided for each bearing arrangement and mounted within the pump body so as to be independent from each other.

Abstract: A vacuum pump incorporating a screw mechanism section and comprising two externally threaded rotors mounted on respective shafts in a pump body. The externally threaded rotors are adapted for counter-rotation in a first chamber within the pump body with intermeshing of the rotor threads in order to pump gas from a pump inlet by action of the rotors. The root diameter of each rotor increases and the thread diameter of each rotor decreases in a direction from pump inlet and in which the gas is pumped. The two externally threaded rotors are positioned in the pump body by means of shaft bearings located inside cavities in the rotors. The cavities are sealed at the ends closest to the pump inlet.

Abstract: A compound vacuum pump incorporating a screw mechanism section. The screw mechanism section comprising two externally threaded rotors mounted on respective shafts in a pump body. The rotors are adapted for counter-rotation in a first chamber within the pump body with intermeshing of the rotor threads to pump gas by action of the rotors. The root diameter of each rotor increases and the thread diameter of each rotor decreases in a direction taken from pump inlet and in which the gas is pumped. The pump additionally incorporates a roots mechanism section comprising two roots-type profile rotors also mounted on the respective shafts and adapted for counter-rotation in a second chamber within the pump body situated at an inlet end of the pump.

Abstract: A turbo-molecular vacuum pump comprising alternate first and second stages. The first stage comprises a plurality of blades arranged in an annular envelope with the blades depending radially from a disc and being angled about radial lines out of the plane of the disc. The second stage comprises a plurality of coaxial, concentric frusto-conical members arrayed in a plane parallel to that of the annular envelope such that at least some of the blades and at least some of the frusto-conical members are axially aligned and are adapted to remain so during rotation of one stage relative to the other.

Abstract: The invention relates to the use of IGF-II for the manufacture of a medicament for the treatment of tumours, and especially for the manufacture of a medicament for growth inhibition of melanoma cells and for the treatment of cutaneous melanomas. The medicament can be systemically or locally administered.

Abstract: A vacuum pump of the regenerative type comprising a rotor and a stator body in which the rotor is adapted for rotation. The rotor has a series of blades positioned in an annular array on a side of the rotor. The stator has an annular channel within which the blades can rotate having a cross-sectional area greater than that of the individual blades except for a small part of the channel which has a reduced cross-section providing a close clearance for the blades. Further, the rotor has at least two series of blades positioned in concentric annular arrays on a side of the rotor and the stator has a corresponding number of channels within which the blades of the arrays can rotate. The channels are linked to form a continuous passageway through which gas being evacuated by the pump can pass.

Abstract: A vacuum pump assembly which comprises at least two cylinders of different diameters and arranged coaxially relative to each other to define an annular space therebetween and a helical member positioned within the space to define a helical path between the cylinders. Rotation of the cylinders is effected relative to the helical member, or vice versa, about their longitudinal axis.

Abstract: A method of testing synchronous dynamic random access memories (SDRAMs) having a pair of memory banks, comprised of writing data into a first of the pair of memory banks at a first clock speed that can be used by a tester, transferring the data at a second clock speed much higher than the first clock speed from the first of the pair of memory banks to a second of the pair of memory banks, and then reading the second of the pair of memory banks at the first clock speed to the tester.