Patents by Inventor Paul Sheppard

Paul Sheppard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GROWTH FACTOR HOMOLOG ZVEGF3
    Publication number: 20070141056
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Application
    Filed: October 24, 2006
    Publication date: June 21, 2007
    Inventors: Zeren Gao, Charles Hart, Christopher Piddington, Paul Sheppard, Kimberly Shoemaker
  • CYTOKINE PROTEIN FAMILY
    Publication number: 20070141676
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 21, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • CYTOKINE PROTEIN FAMILY
    Publication number: 20070128205
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class TI cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 7, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • CYTOKINE PROTEIN FAMILY
    Publication number: 20070128158
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 7, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • CYTOKINE PROTEIN FAMILY
    Publication number: 20070129538
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 7, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070117967
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: May 24, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • USES OF HUMAN ZVEN ANTAGONISTS
    Publication number: 20070092912
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.
    Type: Application
    Filed: October 19, 2006
    Publication date: April 26, 2007
    Inventors: Penny Thompson, Paul Sheppard
  • Uses of human Zven proteins and polynucleotides
    Publication number: 20070087414
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 12, 2006
    Publication date: April 19, 2007
    Inventors: Penny Thompson, Katherine Lewis, Stephen Jaspers, Richard Garcia, Robert West, Susan Holderman, Chung Chan, Paul Sheppard, Anitra Wolf
  • Uses of human Zven proteins and polynucleotides
    Publication number: 20070078259
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 12, 2006
    Publication date: April 5, 2007
    Inventors: Penny Thompson, Katherine Lewis, Stephen Jaspers, Richard Garcia, Robert West, Susan Holderman, Chung Chan, Paul Sheppard, Anitra Wolf
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070073044
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 29, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • Uses of human Zven proteins and polynucleotides
    Publication number: 20070065403
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 12, 2006
    Publication date: March 22, 2007
    Inventors: Penny Thompson, Katherine Lewis, Stephen Jaspers, Richard Garcia, Robert West, Susan Holderman, Chung Chan, Paul Sheppard, Anitra Wolf
  • Uses of humans zven proteins and polynucleotides
    Publication number: 20070065404
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 12, 2006
    Publication date: March 22, 2007
    Inventors: Penny Thompson, Katherine Lewis, Stephen Jaspers, Richard Garcia, Robert West, Susan Holderman, Chung Chan, Paul Sheppard, Anitra Wolf
  • Uses of human Zven proteins and polynucleotides
    Publication number: 20070065405
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 12, 2006
    Publication date: March 22, 2007
    Inventors: Penny Thompson, Katherine Lewis, Stephen Jaspers, Richard Garcia, Robert West, Susan Holderman, Chung Chan, Paul Sheppard, Anitra Wolf
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070066810
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 22, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • ADIPOCYTE COMPLEMENT RELATED PROTEIN ZACRP3X2
    Publication number: 20070066811
    Abstract: Novel zacrp3x2 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp3x2 protein or fragments thereof.
    Type: Application
    Filed: November 13, 2006
    Publication date: March 22, 2007
    Inventors: Betty Haldeman, Edward Thayer, Paul Sheppard
  • Homogeneous preparations of IL-28 and IL-29
    Publication number: 20070065406
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 13, 2006
    Publication date: March 22, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Boukowski
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070059313
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 15, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • GROWTH FACTOR HOMOLOG ZVEGF3
    Publication number: 20070060507
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Application
    Filed: October 24, 2006
    Publication date: March 15, 2007
    Inventors: Zeren Gao, Charles Hart, Christopher Piddington, Paul Sheppard, Kimberly Shoemaker
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070059804
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 18, 2006
    Publication date: March 15, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070053875
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 17, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski