Patents by Inventor Paul Sheppard

Paul Sheppard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070055052
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070054375
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 17, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070055053
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • USES OF HUMAN ZVEN ANTAGONISTS
    Publication number: 20070053907
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 8, 2007
    Inventors: Penny Thompson, Paul Sheppard
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070055054
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070055051
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 16, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070054376
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 18, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • IL28 and IL29 TRUNCATED CYSTEINE MUTANTS AND ANTIVIRAL METHODS OF USING SAME
    Publication number: 20070053933
    Abstract: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
    Type: Application
    Filed: July 20, 2006
    Publication date: March 8, 2007
    Inventor: PAUL SHEPPARD
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070054377
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • USES OF HUMAN ZVEN ANTAGONISTS
    Publication number: 20070053908
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.
    Type: Application
    Filed: October 19, 2006
    Publication date: March 8, 2007
    Inventors: Penny Thompson, Paul Sheppard
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070054374
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 17, 2006
    Publication date: March 8, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • GROWTH FACTOR HOMOLOG ZVEGF4
    Publication number: 20070048829
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Application
    Filed: October 17, 2006
    Publication date: March 1, 2007
    Inventors: Teresa Gilbert, Charles Hart, Paul Sheppard
  • INTERFERON-LIKE PROTEIN ZCYTO21
    Publication number: 20070049736
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 1, 2007
    Inventors: Paul Sheppard, Scott Presnell, Brian Fox, Teresa Gilbert, Betty Haldeman, Francis Grant
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070048844
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 17, 2006
    Publication date: March 1, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29
    Publication number: 20070048275
    Abstract: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
    Type: Application
    Filed: October 16, 2006
    Publication date: March 1, 2007
    Inventors: Lowell Brady, Kevin Klucher, Chung Chan, Dennis Dong, Hong Liu, Paul Sheppard, Thomas Bukowski
  • Methods of using Zven antibodies
    Publication number: 20070048805
    Abstract: The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.
    Type: Application
    Filed: October 13, 2006
    Publication date: March 1, 2007
    Inventors: PAUL SHEPPARD, Paul Bishop, Theodore Whitmore, Penny Thompson
  • Human Zven polynucleotides
    Publication number: 20070048840
    Abstract: The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.
    Type: Application
    Filed: October 13, 2006
    Publication date: March 1, 2007
    Inventors: Paul Sheppard, Paul Bishop, Theodore Whitmore, Penny Thompson
  • INTERFERON-LIKE PROTEIN ZCYTO21
    Publication number: 20070048841
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 1, 2007
    Inventors: Paul Sheppard, Scott Presnell, Brian Fox, Teresa Gilbert, Betty Haldeman, Francis Grant
  • Uses of human Zven proteins and polynucleotides
    Publication number: 20070049526
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 12, 2006
    Publication date: March 1, 2007
    Inventors: Penny Thompson, Katherine Lewis, Stephen Jaspers, Richard Garcia, Robert West, Susan Holderman, Chung Chan, Paul Sheppard, Anitra Wolf
  • Use of human Zven proteins and polynucleotides
    Publication number: 20070048258
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
    Type: Application
    Filed: October 12, 2006
    Publication date: March 1, 2007
    Inventors: Penny Thompson, Katherine Lewis, Stephen Jaspers, Richard Garcia, Robert West, Susan Holderman, Chung Chan, Paul Sheppard, Anitra Wolf