Patents by Inventor Paul Slattum

Paul Slattum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intravascular delivery of non-viral nucleic acid
    Publication number: 20050153451
    Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
    Type: Application
    Filed: October 28, 2004
    Publication date: July 14, 2005
    Inventors: Jon Wolff, Vladimir Budker, James Hagstrom, Hans Herweijer, Julia Hegge, Paul Slattum, Sean Monahan, David Rozema
  • Polyampholytes for delivering polyions to a cell
    Publication number: 20050037496
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: July 26, 2004
    Publication date: February 17, 2005
    Inventors: David Rozema, Vladimir Budker, James Hagstrom, Vladimir Trubetskoy, Jon Wolff, Sean Monahan, Paul Slattum
  • Genetic vaccines for cancer therapy
    Publication number: 20050036995
    Abstract: The present invention relates to methods for delivering a genetic immunogen comprising a polynucleotide capable of expressing an antigen. The polynucleotide is delivered to the host via an intravascular route resulting in delivery to extravascular cells, expression of an encoded antigen and induction of an antigen-specific immune response. The methods may be used to enhance an immune response against a cancer cell related antigen.
    Type: Application
    Filed: July 16, 2004
    Publication date: February 17, 2005
    Inventors: Hans Herweijer, Mary Bates, Vladimir Budker, James Hagstrom, Sean Monahan, David Rozema, Paul Slattum, John Wolff
  • Compound containing a labile disulfide bond
    Publication number: 20050020518
    Abstract: A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
    Type: Application
    Filed: February 8, 2001
    Publication date: January 27, 2005
    Inventors: Jon Wolff, Sean Monahan, Vladimir Budker, Paul Slattum, David Rozema