Abstract: This disclosure relates to ruxolitinib, or a pharmaceutically acceptable salt thereof, and its use in treating prurigo nodularis.

Abstract: The invention refers to a method for producing expanded polymer pellets, which comprises the following steps: melting a polymer comprising a polyamide; adding at least one blowing agent; expanding the melt through at least one die for producing an expanded polymer; and pelletizing the expanded polymer. The invention further concerns polymer pellets produced with the method as well as their use, e.g. for the production of cushioning elements for sports apparel, such as for producing soles or parts of soles of sports shoes. A further aspect of the invention concerns a method for the manufacture of molded components, comprising loading pellets of an expanded polymer material into a mold, and connecting the pellets by providing heat energy, wherein the expanded polymer material of the pellets or beads comprises a chain extender. The molded components may be used in broad ranges of application.

Abstract: A firearm with a slide and a frame. The slide has a slide rail. The frame has a frame rail. The frame rail interfaces with the slide rail. The frame rail has a lubrication groove and a debris removal port. The lubrication groove extends along a surface of the frame rail that bears against the slide rail during operation of the firearm. The debris removal port has gap within the frame rail proximate to an end of the lubrication groove.

Abstract: An agent delivery device comprises: one or more agent containers at a proximal end of the agent delivery device, wherein the one or more agent containers are configured to contain one or more fluids; an insertion section comprising a tube defining one or more lumens, the insertion section coupled to the agent containers such that the one or more fluids may flow from the agent containers to the one or more lumens and out of one or more outlets of the one or more lumens; and a distal impingement structure at the distal end of the insertion section, the distal impingement structure comprising an impingement surface arranged relative to one or more outlets to impinge the one or more fluids dispensed from the one or more outlets to cause mixing of the one or more fluids for application of the fluids at a treatment site.

Abstract: A clipping system includes an adapter, a clip and a first extending member. The clip includes first and second jaws which are movable between an insertion configuration and an initial deployed configuration. The jaws are biased toward the initial configuration. The first member is releasably coupled to the clip and movably connected to the adapter. The first member includes a distal end releasably coupled to the first jaw such that longitudinal movement of the first member relative to the adapter moves the clip between the insertion configuration, the initial configuration and a review configuration. The first member is operable to retract the clip proximally over the adapter so that the clip is forced open as the clip is retracted over the adapter. A first releasable link connects the first member to the clip and releases when the first member is subject to a force exceeding a predetermined threshold value.

Abstract: The present disclosure relates to materials and systems to manage thermal runaway issues in energy storage systems. Exemplary embodiments include an insulation layer that is placed in the encapsulation material used to encapsulate a pouch battery cell. The encapsulation layer for a pouch battery cell is made from a laminate film that comprises an insulation layer.

Abstract: A pouring attachment device for a disposable package of nitrogenated beverage, e.g. an aluminium can P, that achieves a desirable foam head when the beverage is poured into a glass. The attachment comprises a main body or housing (11), an ultrasonic wave generator (27) and a means to couple the device to the package, such as a rim seal (2)0. A flow channel has a contoured inlet (26) configured for communicating beverage from the package to an outlet (21), via a resonance chamber (28), and is particularly configured for minimising turbulence.

Abstract: A medical device may comprise a handle, wherein the handle includes a movable body and a main body; a cap configured to be coupled to a distal end of a scope; a patch, wherein the patch is moveable relative to the cap; and a petal body. The patch may be removably coupled to the petal body. The medical device may further comprise an actuator body coupling the patch to the moveable body such that movement of the moveable body extends the patch from the cap. The petal body may be configured to transition between a closed configuration in which the patch is retracted, and an open configuration in which the patch is extended radially-outward from a central longitudinal axis of the scope.

Abstract: A medical device may include a needle, including a plurality of links and a distal tip, reciprocally movable between a first configuration and a second configuration, and a conduit including a lumen extending through the needle, the conduit being coupled to the distal tip, wherein longitudinal movement of the conduit is configured to transition the needle between the first configuration and the second configuration.

Abstract: A tissue fastening device includes a body including a plurality of sidewalls defining a channel, an anvil having a proximal end and a distal end and pivotally coupled to the body and the anvil moves between an open position and a closed position, and a locking mechanism to lock the anvil in the closed position.

Abstract: The technology described herein is directed to a food assembly and packaging robot for automating aspects of food assembly and packaging. The food assembly and packaging robot system may include a robot system include a conveyance system, a bowl dispenser, one or more food dispensers, one or more condiment dispensers, a lidder, and a bagger, and in some instances, other components. The bowl dispenser may be configured to deposit bowls onto the conveyance system. The one or more food dispensers may be configured to deposit one or more ingredients into the bowls and the one or more condiment dispensers may be configured to deposit one or more condiments into the bowls. The lidder may be configured to position lids atop the bowls and the bagger may be configured to place the bowls into bags.

Abstract: A clipping system includes an adapter and a clip. The adapter is mounted over a distal end of an insertion device to a distal end and has a first annular groove formed in a distal face of the adapter. The clip has a body; a central body having a coupling portion and a ring; and jaws having outer arms coupled to the body at an outer arm proximal end and inner arms disposed radially inward of the outer arms and coupled to the ring at an inner arm proximal end. The body includes an annular protrusion extending proximally from a proximal surface of the body. The protrusion is inserted into the first groove of the adapter to couple the clip to the adapter. Movement of the central body along an axis of the clip causes movement of the jaws between an insertion configuration and a deployment configuration.

Abstract: A medical system includes a medical device having a handle, a shaft, an actuation member, and medical system also includes a cartridge and a plunger. The handle includes an actuator movable relative to the handle, and the actuator is coupled to a distal end of the shaft via the actuation member. The cartridge contains a treatment agent, and the cartridge is couplable to the distal end of the shaft. The plunger is movable relative to the cartridge. Movement of the actuator controls movement of the actuation member. Movement of the actuation member controls movement of either the plunger or the cartridge to control a delivery of the treatment agent from the cartridge.

Abstract: A system includes an adapter mounted over a distal end of an insertion device, a clip and a first extending member. The clip includes jaws movable between an insertion configuration, with the jaws separated and an initial deployed configuration with the jaws drawn together. The clip is biased toward the initial configuration. The first jaw includes a connection element and a first member releasably coupled to the first jaw connection element permits movement of the adapter relative to the clip while the first member remains coupled to the clip to enhance visual observation of the clip. The first member retracts the clip proximally over the adapter so that the clip is forced open as the clip is retracted over the adapter freeing the clip from tissue on which it had been clipped.

Abstract: Handguns are disclosed including improved safety mechanisms, improved magazine catch mechanisms, improved slide stop mechanisms, and improved optics mounts. Selected embodiments may include one or more than one of such improvements. Embodiments may be particularly suited to semi-automatic handguns, including 1911-style handguns and/or 2011-style handguns. Other embodiments may also be implemented in the context of different types of handguns.

Abstract: Handguns are disclosed including improved safety mechanisms, improved magazine catch mechanisms, improved slide stop mechanisms, and improved optics mounts. Selected embodiments may include one or more than one of such improvements. Embodiments may be particularly suited to semi-automatic handguns, including 1911-style handguns and/or 2011-style handguns. Other embodiments may also be implemented in the context of different types of handguns.

Abstract: Handguns are disclosed including improved safety mechanisms, improved magazine catch mechanisms, improved slide stop mechanisms, and improved optics mounts. Selected embodiments may include one or more than one of such improvements. Embodiments may be particularly suited to semi-automatic handguns, including 1911-style handguns and/or 2011-style handguns. Other embodiments may also be implemented in the context of different types of handguns.

Abstract: The disclosure relates generally to the field of medical devices for accessing body lumens. In an embodiment, a catheter may include a shaft having a proximal end, a distal end, and a length along a longitudinal axis extending through the shaft. A plurality of lumens may extend along the length of the shaft. At least one reinforcing filament may extend along the length of the shaft and between at least two of the plurality of lumens.

Abstract: A suture device may include a suture translation assembly configured to be axially translatable within a lumen of a delivery system and a distal assembly configured to be securable to the distal end of the delivery system. The suture translation assembly and the distal assembly may cooperate to enable a user to pass a needle back and forth between the two in order to endoscopically suture a defect.

Abstract: A firearm with a slide and a frame. The slide has a slide rail. The frame has a frame rail. The frame rail interfaces with the slide rail. The frame rail has a lubrication groove and a debris removal port. The lubrication groove extends along a surface of the frame rail that bears against the slide rail during operation of the firearm. The debris removal port has gap within the frame rail proximate to an end of the lubrication groove.