Abstract: Coordinated application processing includes obtaining a plurality of images and distributing them to processing engines to perform image processing. The plurality of images cover an image area, with different sub-areas, in which a biological sample to be sequenced is present. The image processing proceeds across multiple cycles to process a respective set of images, of the plurality of images, of each sub-area of the different sub-areas, and therefore of the respective area, of the flow cell, to which that sub-area correlates. The distributing the plurality of images includes, for each sub-area of the different sub-areas, distributing, across the multiple cycles of the image processing, the images of the respective set of images of that sub-area to a respective processing engine, of a plurality of processing engines, associated with, and selected for, processing images of that sub-area.

Abstract: Modular connectors and methods are disclosed that provide two sides of a connector in modular and interchangeable fashion. The modular design can be enhanced to add various useful features to one or both sides of the connectors, including the use of rods, hooks, rod receivers of various configurations, etc. This modular approach can allow the assembly of various unique connectors from a pool of components that are interchangeable while minimizing manufacturing cost and complexity.

Abstract: Surgical instruments for interfacing with implants can include an inserter configured to dock to a unilateral portion of an implant. The inserter can include a control shaft that is configured to lock or unlock the inserter coupling with the implant. Actuation of the control shaft can occur by way of a knob that can control movement of the control shaft. The inserter can facilitate positioning of the implant relative to a surgical site and allow for application of counter-torque when imparting torque for tightening a set screw, etc. Additional instruments can also be used to manipulate the implant. For example, auxiliary instruments can be coupled to the inserter, such as a reducer instrument, to facilitate rod reduction, etc. Alternatively or in addition, a holder instrument can be used that has a threaded distal engagement feature for coupling to the implant to facilitate positioning thereof.

Abstract: Provided herein are purification, production and manufacturing methods for recombinant viral vector particles such as recombinant adeno-associated viral (rAAV) vector particles substantially free of empty viral particles; a population of recombinant adeno-associated vims (rAAV) particles purified using the method described herein, and a pharmaceutical composition comprising the purified rAAV.

Abstract: Apparatuses and methods for creating phobic and philic surfaces (for example, superphobic and superphilic surfaces) are disclosed. Embodiments include methods for determining a heat treatment technique that increases the likelihood that a uniformly etched surface with minimal pitting will be formed when the surface of a material is subject to etching. Additional embodiments include evaluating the PRE number of the material, performing an anodic polarization sweep of the material, evaluating the polarization curve (current vs. potential) for the material, performing different etching protocols depending on the range of values the PRE number of the material belongs, and/or pulsing the current applied to the material during the etching process. Additional embodiments include apparatuses and methods for predictably etching a surface (such as a surface of a metal alloy) of a material, which can include etching interior portions of a hollow work piece.

Abstract: A shingle coating asphalt composition is provided that is produced from a paving grade asphalt. The asphalt composition comprises a paving-grade asphalt that has been modified with one or more polymer additives; and a secondary additive comprising one or more of a viscosity reducing agent, a wax, a salt of a fatty acid ester, and an amide of a fatty acid. The shingle coating asphalt coating composition is used to make a shingle. The shingle includes a substrate, the asphalt, and roofing granules.

Abstract: This disclosure relates to ruxolitinib, or a pharmaceutically acceptable salt thereof, and its use in treating prurigo nodularis.

Abstract: A medical device including an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The medical device may further include an end-effector disposed at the distal end of the elongate member. The end-effector may include a plurality of arms pivotally connected to one another, wherein each arm includes a tissue-contacting surface, a first portion of the tissue-contacting surface including a plurality of ridges configured to grasp tissue. Further, the tissue-contacting surface may include a channel oriented substantially parallel to a longitudinal axis of the medical device.

Abstract: Inductive position sensors for sensing relative position (e.g., relative rotary position) between members are provided. In one example implementation, the inductive position sensor includes a transmit aerial having at least one transmit winding. The inductive position sensor can include a receive aerial having one or more receive windings. The inductive position sensor can include a coupling element operable to be disposed on the second member. The inductive position sensor can include processing circuitry configured to provide one or more signals indicative of the position of the first member relative to the second member based on current induced in the one or more receive windings resulting from an oscillating signal provided to the transmit winding. The inductive position sensor includes at least one electrostatic shield. The electrostatic shield can include a plurality of conductive traces arranged so that no current loops are formed in the electrostatic shield.

Abstract: A device includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough. The capsule is releasably coupled to a proximal portion of the device. Device also includes a first arm rigidly fixed to the distal end of the capsule to extend distally therefrom. In addition, Device includes a second arm, a proximal end of which is slidably received within the capsule so that the second arm is movable between an open configuration, in which the second arm is moved laterally away from the first arm and a distal end of the second arm is moved distally past the distal end of the first arm, and a closed configuration, in which the second arm is moved toward the first arm and the distal end of the second arm is moved proximally toward the distal end of the first arm.

Abstract: A semiconductor device includes a cell array having tracks and rows formed on a substrate. The tracks extend perpendicularly to the rows. A logic cell is formed across two adjacent rows within the cell array. The logic cell includes a cross-couple (XC) in each row and a plurality of poly tracks across the two adjacent rows. Each XC includes two cross-coupled complementary field-effect-transistors. Each poly track is configured to function as an inter-row gate for the XCs. A pair of signal tracks is positioned on opposing boundaries of the logic cell and electrically coupled to the plurality of poly tracks.

Abstract: The present application provides combination therapies comprising a JAK inhibitor and a ROCK inhibitor, and methods of using the same to treat disorders such as graft versus host disease (GVHD), restrictive allograft syndrome (RAS), chronic lung allograft dysfunction (CLAD), and systemic sclerosis (scleroderma).

Abstract: A method for coupling a first medical device component to a second medical device component comprising altering the first medical device component from a natural state to an altered state, by reducing a cross-sectional dimension of the first medical device, fitting a first portion of the first medical device component in the altered state into a first opening of the second medical device component, wherein the first medical device component includes second portions not within the first opening of the second medical device component, and allowing the second portions of the first medical device component to revert back to the natural state.

Abstract: A carrier card for reduced width circuit card assemblies are described. The carrier card includes a U-shaped design. A daughter card mounts in a void in the carrier card in a co-planar fashion. The carrier card includes an upper member; a lateral member, a lower member and a front panel with optional snout. The lateral member or other member includes a carrier card electrical and/or optical connector. The lower member or other member includes a mating electrical and/or optical connector to connect with the daughter card. The upper member, the lateral member, and the lower member form or define the void. A front panel connects with the upper and lower member and, optionally, the daughter card to provide structural integrity and provides additional I/O for the assembly.

Abstract: Methods and systems for coupling gas and water supply tubes to a container. An illustrative container and tube set may comprise a container configured to contain a fluid, the container having a bottom portion and a top portion, a water supply tube including a first end, a second end, and a first lumen, a gas supply tube including a first end, a second end, and a second lumen, and a weight coupled to the first end of the water supply tube and a first end of the gas supply tube. The first lumen may be in selective fluid communication with the bottom portion of the container and the second end of the water supply tube positioned external to the container. The second lumen may be in operative fluid communication with the container and the second end of the gas supply tube is positioned external to the container.

Abstract: A fluid management and medical device system may include a fluid management system and a medical device having one or more sensors proximate the distal end of the elongate shaft of the medical device. The controller of the fluid management system may be configured to calculate a fluid deficit when the distal end of the elongate shaft is disposed within a patient and configured to automatically pause fluid deficit calculation when the distal end of the elongate shaft is removed from the patient. In some instances the controller is configured to calculate the fluid deficit using rotational speed of the inflow pump in combination with a difference between a change in weight of a fluid supply source supplying fluid to the fluid management system and a change in weight of a collection container collecting fluid from the fluid management system.

Abstract: Technologies and implementations for a defibrillator electrode having communicative capabilities are generally disclosed.

Abstract: A flexible service-based architecture (SBA) for next generation communication networks is described. In an embodiment, a method performed by a system comprising a processor comprises receiving a service request for provision of a data communication service to a communication device via a communication network comprising a plurality of different network resources defined by resource components and sub-components of the resource components. In response to receiving the service request, accessing network resource abstraction information that identifies the resource components, and the sub-components respectively associated with the resource components, and selecting a subset of the different network resources for the provision of the data communication service to the communication device based a service criterion associated with the data communication service.