Abstract: A crankcase assembly for an engine is provided. The crankcase assembly includes a crankcase comprising a crank sump, the crank sump including a primary sump volume and a secondary sump volume, one or more crankcase oil catchers, the crankcase oil catchers comprising one or more surfaces configured to catch dispersed oil in the crankcase and direct the oil along the surfaces of the crankcase oil catcher away from a crankcase casing wall and towards the crank sump, wherein the crankcase oil catchers are provided above a crankshaft and below an associated piston of the engine, and one or more guides configured to collect oil captured by the crankcase oil catchers and guide the oil to the primary sump volume.

Abstract: The invention relates to a multiparticulate modified release composition that, upon administration to a patient, delivers at least one active ingredient in a bimodal or multimodal manner. The multiparticulate modified release composition comprises a first component and at least one subsequent component; the first component comprising a first population of active ingredient containing particles and the at least one subsequent component comprising a second population of active ingredient containing particles wherein the combination of the components exhibit a bimodal or multimodal release profile. The invention also relates to a solid oral dosage form containing such a multiparticulate modified release composition.

Abstract: A bearing block assembly in an engine is provided. The bearing block assembly includes at least one bearing block to rotatably support an oil lubricated shaft and fastening apparatus to attach the at least one bearing block to a flat mounting surface on a large engine component and a thermal barrier positioned between the shaft and the flat mounting surface configured to reduce the loss of heat to the large engine component from oil used to lubricate the shaft.

Abstract: An article and method for reducing somnolence in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release multiparticulate composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

Abstract: An engine block has one or more bores configured for receiving one or more respective pistons; one or more coolant passages; and one or more lubricant passages. At least portions of the coolant passages and lubricant passages are disposed adjacent to and about the bores so as to cool the bores. The coolant passage portion extends over a first lengthwise portion of the bores and the lubricant passage portion extending over a second lengthwise portion of the bores. The first and second lengthwise portions are longitudinally spaced apart along the bores.

Abstract: A crankcase oil catcher configured for placement above a crankshaft and below a piston is described. In one particular example, the crankcase oil catcher has a contour that catches dispersed oil within the crankcase while directing the oil away from a casing wall and towards a crank sump along the contoured surface of the crankcase oil catcher. Inclusion of an aperture within the surface allows for passage of a connecting rod of the crankshaft while providing for a protruding lip around the perimeter of the aperture that prevents oil on the top surface from falling through the aperture.

Abstract: An apparatus for heating a fluid such as engine oil includes an auxiliary pump, a conduit connected to the auxiliary pump and provides fluid communication from the auxiliary pump and an aperture in the conduit. In use the auxiliary pump contains the fluid. A first portion of the fluid is pumped into the conduit by the auxiliary pump and a second portion of the fluid remains in the auxiliary pump. The aperture restricts the flow of the first portion of the fluid in the conduit. The second portion of the fluid is heated due to friction between the second portion of the fluid and the pump. There is also described a method of heating a fluid.

Abstract: An engine system is disclosed in which the transfer of heat from pressurized oil flowing through an integrally formed oil transfer passage of the engine is reduced by providing a thermal barrier between the oil and the engine. In one example the thermal barrier is provided by the use of a thick walled plastic tube and in other embodiments ribs are used to separate an oil flow passage from the engine.

Abstract: The present invention relates to formulations comprising therapeutically effective amounts of at least one acid-stable, carrier-mediated transport statin, at least one poorly water-soluble, carrier-mediated transport statin, or at least one large molecular weight, carrier-mediated transport statin, such as atorvastatin and rosuvastatin, or a pharmaceutically acceptable salt thereof, and methods of their use. The present formulations and methods are designed to exhibit a controlled-release of a therapeutic amount of the statin in the small intestine, thereby limiting systemic exposure of the statin and maximizing liver-specific absorption of the drug. The formulations and methods of the present invention are particularly useful for treating and/or preventing conditions that are benefited by decreasing levels of lipids and/or cholesterol in the body.

Abstract: The present invention relates to formulations comprising therapeutically effective amounts of at least one acid-stable, carrier-mediated transport statin, at least one poorly water-soluble, carrier-mediated transport statin, or at least one large molecular weight, carrier-mediated transport statin, such as atorvastatin and rosuvastatin, or a pharmaceutically acceptable salt thereof, and methods of their use. The present formulations and methods are designed to exhibit a controlled-release of a therapeutic amount of the statin in the small intestine, thereby limiting systemic exposure of the statin and maximizing liver-specific absorption of the drug. The formulations and methods of the present invention are particularly useful for treating and/or preventing conditions that are benefited by decreasing levels of lipids and/or cholesterol in the body.

Abstract: An article and method for increasing the extent of tizanidine absorption in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release tablet composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

Abstract: An article and method for reducing somnolence in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release multiparticulate composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

Abstract: A bearing block assembly in an engine is provided. The bearing block assembly includes at least one bearing block to rotatably support an oil lubricated shaft and fastening apparatus to attach the at least one bearing block to a flat mounting surface on a large engine component and a thermal barrier positioned between the shaft and the flat mounting surface configured to reduce the loss of heat to the large engine component from oil used to lubricate the shaft.

Abstract: An apparatus for heating a fluid such as engine oil includes an auxiliary pump, a conduit connected to the auxiliary pump and provides fluid communication from the auxiliary pump and an aperture in the conduit. In use the auxiliary pump contains the fluid. A first portion of the fluid is pumped into the conduit by the auxiliary pump and a second portion of the fluid remains in the auxiliary pump. The aperture restricts the flow of the first portion of the fluid in the conduit. The second portion of the fluid is heated due to friction between the second portion of the fluid and the pump. There is also described a method of heating a fluid.

Abstract: An engine system is disclosed in which the transfer of heat from oil flowing through an integrally formed oil transfer passage of the engine is reduced by providing a thermal barrier between the oil and the engine. In one example the thermal barrier is provided by the use of a thick walled plastic tube and in other embodiments ribs are used to separate an oil flow passage from the engine.

Abstract: An article and method for reducing somnolence in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release multiparticulate composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

Abstract: An article and method for increasing the extent of tizanidine absorption in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release tablet composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

Abstract: An article and method for increasing the extent of tizanidine absorption in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release tablet composition at or around the time food is consumed. The composition may be packaged in a container for distribution.

Abstract: The present invention provides a composition comprising a cefditoren, or a salt, derivative, prodrug, or other form thereof, for example, cefditoren pivoxil, useful in the treatment and prevention of infections and related conditions. The invention provides a composition which comprises nanoparticulate particles comprising the cefditoren, or a salt, derivative, prodrug, or other form thereof and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. The invention provides also a composition that delivers a cefditoren, or a salt, derivative, prodrug, or other form thereof, or nanoparticles comprising the same, in a pulsatile or continuous manner.

Abstract: An article and method for reducing somnolence in a patient receiving tizanidine therapy. Tizanidine may be administered in the form of an immediate release multiparticulate composition at or around the time food is consumed. The composition may be packaged in a container for distribution.