Patents by Inventor Paul W. Collins
Paul W. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5504215Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: June 1, 1995Date of Patent: April 2, 1996Assignee: G. D. Searle & Co.Inventors: John J. Talley, Thomas D. Penning, Paul W. Collins, Donald J. Rogier, Jr., James W. Malecha, Julie M. Miyashiro, Stephen R. Bertenshaw, Ish K. Khanna, Matthew J. Graneto, Roland S. Rogers, Jeffery S. Carter
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Patent number: 5466823Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: November 30, 1993Date of Patent: November 14, 1995Assignee: G.D. Searle & Co.Inventors: John J. Talley, Thomas D. Penning, Paul W. Collins, Donald J. Rogier, Jr., James W. Malecha, Julie M. Miyashiro, Stephen R. Bertenshaw, Ish K. Khanna, Matthew J. Graneto, Roland S. Rogers, Jeffery S. Carter
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Patent number: 5218139Abstract: A method is described for inhibiting IgE production which comprises administering, in an amount effective to inhibit IgE production, a prostaglandin of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof, in which R is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, or mono, di- or tri-substituted phenyl in which the substituents are selected form the group consisting of bromo, chloro, fluoro, iodo, C.sub.1 -C.sub.5 alkyl, hydroxy, nitro, acetyl, alkoxy, carboxy, acetoxy, amino, mono- or di- alkyl amino, amido and acetamido; R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.5 alkyl, n.sub.3, n.sub.4, n.sub.5, n.sub.6, n.sub.7, and n.sub.8 independently are zero or one; when n's are zeros, R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, R.sub.5 and R.sub.6 together, and R.sub.7 and R.sub.8 together are double bonds; when n's are ones, R.sub.3, R.sub.5, R.sub.6 R.sub.7 and R.sub.8 independently are hydrogen, R.sub.Type: GrantFiled: June 3, 1992Date of Patent: June 8, 1993Assignee: G. D. Searle & Co.Inventors: Alan D. Levine, Paul W. Collins
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Patent number: 5177251Abstract: The present invention relates to a novel class of halogenated tetraenyl prostaglandin compounds represented by the following general formula ##STR1##or a pharmaceutically acceptable salt thereof, whereinY is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --;R.sub.1 is H or a lower alkyl of 1 to 6 carbons;n is an integer from 0 to 3;m is an integer from 0 to 3 and n+m=3; X is Cl or F provided that when X is Cl, n is 2 and m is 1;R.sub.2 and R.sub.3 are independently H, lower alkyl from 1 to 6 carbons, Cl, --CH.sub.2 Cl, --CH.sub.2 F, --CHCl.sub.2, --CCl.sub.3, or taken together form a cycloalkyl of 3 to 6 carbons;R.sub.4 is H, lower alkyl from 1 to 6 carbons, Cl, F or taken together with R.sub.3 form a cycloalkenyl of 4 to 6 carbons; and provided that at least one of --CH.sub.n X.sub.m, R.sub.2, R.sub.3 and R.sub.4 includes a chlorine or fluorine atom.Type: GrantFiled: December 24, 1991Date of Patent: January 5, 1993Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Steven W. Kramer, Robert L. Shone
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Patent number: 5157052Abstract: A method is described for inhibiting IgE production which comprises administering, in an amount effective to inhibit IgE production, a prostaglandin of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof, in which R is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, or mono, di- or tri-substituted phenyl in which the substituents, are selected from the group consisting of bromo, chloro, fluoro, iodo, C.sub.1 -C.sub.5 alkyl, hydroxy, nitro, acetyl, alkoxy, carboxy, acetoxy, amino, mono- or di- alkyl amino, amido and acetamido; R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.5 alkyl, n.sub.3, n.sub.4, n.sub.5, n.sub.6, n.sub.7, and n.sub.8 independently are zero or one; when n's are zeros, R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, R.sub.5 and R.sub.6 together, and R.sub.7 and R.sub.8 together are double bonds; when n's are ones, R.sub.3, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 independently are hydrogen, R.sub.Type: GrantFiled: December 27, 1990Date of Patent: October 20, 1992Assignee: Monsanto CompanyInventors: Alan D. Levine, Paul W. Collins
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Patent number: 5153220Abstract: Tetraenyl Prostanoic Acid derivatives which are useful as prodrugs for the treatment of peptic ulcer disease and are represented by the following general formula ##STR1## are disclosed.Type: GrantFiled: November 4, 1991Date of Patent: October 6, 1992Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 5089524Abstract: Tetraenyl Prostanoic Acid derivatives which are useful as prodrugs for the treatment of peptic ulcer disease and are represented by the following general formula ##STR1## are disclosed.Type: GrantFiled: June 28, 1990Date of Patent: February 18, 1992Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 5055569Abstract: The present invention relates to N-(6)-substituted adenosine compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Z is an amine and R.sub.1 and R.sub.2 are independently hydrogen, hydroxyl, halogen, alkyl, phenyl, alkoxy, morpholino, piperidino, piperazino, phenoxy, thiophenoxy or amino optionally substituted by alkyl, aralkyl or phenyl.Type: GrantFiled: October 19, 1989Date of Patent: October 8, 1991Assignee: G. D. Searle & Co.Inventors: Daniel P. Becker, Paul W. Collins, Daniel L. Flynn
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Patent number: 4863961Abstract: This invention encompasses prostaglandins of the formula ##STR1## wherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R.sub.1 represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R.sub.2, R.sub.3, and R.sub.4 are hydrogen or lower alkyl having 1 to 4 carbon atoms or R.sub.2 and R.sub.3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R.sub.3 and R.sub.4 together with carbons X and Y form a cycloalkenyl having 4 to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly lower diarrheogenic side effects.Type: GrantFiled: July 28, 1988Date of Patent: September 5, 1989Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 4847293Abstract: This invention encompasses prostaglandins of the formula ##STR1## wherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R.sub.1 represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and a wavy line represents R or S stereochemistry; R.sub.2, R.sub.3, and R.sub.4 are hydrogen or lower alkyl having 1 to 4 carbon atoms or R.sub.2 and R.sub.3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R.sub.3 and R.sub.4 together with carbons X and Y form a cycloalkenyl having 4 to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly low diarrheogenic side effects.Type: GrantFiled: June 10, 1988Date of Patent: July 11, 1989Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 4820728Abstract: This invention encompasses prostaglandins of the formula ##STR1## wherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R.sub.1 represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R.sub.2, R.sub.3, and R.sub.4 are hydrogen or lower alkyl having 1 to 4 carbom atoms or R.sub.2 and R.sub.3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R.sub.3 and R.sub.4 together with carbons X and Y form a cycloalkenyl having 4 to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly low diarrheogenic side effects.Type: GrantFiled: June 30, 1987Date of Patent: April 11, 1989Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 4754059Abstract: This invention encompasses prostaglandins of the formula I ##STR1## wherein X represents cis or trans --CH.dbd.CH--, --C.tbd.C--, methylene or ethylene;R.sub.1 represents a cycloalkyl group of the formula ##STR2## where m is 1 to 3 inclusive;R.sub.2 represents hydrogen or lower alkyl with the proviso that the sum of the carbon atoms in X and R.sub.1 is 7 or less;R' represents lower alkyl containing 1 to 6 carbon atoms, vinyl or ethynyl;wherein R'" represents hydroxymethyl, hydroxyacetyl or --CO.sub.2 R""wherein R"" represents hydrogen or lower alkyl containing 1 to 6 carbon atoms and the wavy line represents optional R or S stereochemistry.Type: GrantFiled: November 7, 1984Date of Patent: June 28, 1988Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 4713477Abstract: This invention encompasses prostaglandins of the formula I ##STR1## wherein R represents hydrogen or lower alkyl containing 1 to 6 carbon atoms;X represents --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 --C.tbd.C--, --CH.sub.2 --CH.dbd.CH-- --CH.sub.2 --CH.sub.2 --CH.sub.2, --CH.dbd.CH--CH.sub.2 --, --C.tbd.C--CH.sub.2 --; andR.sub.1 represents cyclopropyl, cyclobutyl, cyclopentyl, 1-methylcyclopropyl or 1-methylcyclobutyl or XR.sub.1 together represent 1-methyl-1-cyclopropylethyl or 1-methyl-1-cyclobutylethyl; and R.sub.2 is lower alkyl having 1 to 4 carbon atoms or vinyl or ethynyl; the wavy line represents optional R or S sterochemistryThese compounds are potent antisecretory agents.Type: GrantFiled: November 14, 1985Date of Patent: December 15, 1987Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 4689419Abstract: This invention relates to the production of novel intermediate compounds which are useful in the process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives, the antisecretory agents of U.S. Pat. No. 4,178,457.Type: GrantFiled: November 14, 1986Date of Patent: August 25, 1987Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Richard M. Weier
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Patent number: 4683328Abstract: This invention encompasses prostaglandins of the formula ##STR1## wherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R.sub.1 represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R.sub.2, R.sub.3, and R.sub.4 are hydrogen or lower alkyl having 1 to 4 carbon atoms or R.sub.2 and R.sub.3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R.sub.3 and R.sub.4 together with carbons X and Y form a cycloalkenyl having 4 to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly low diarrheogenic side effects.Type: GrantFiled: November 25, 1985Date of Patent: July 28, 1987Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki
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Patent number: 4617411Abstract: This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E.sub.2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypertensive activity. In addition the invention also discloses certain novel trialkylsilyl acetylenic intermediates.Type: GrantFiled: March 25, 1985Date of Patent: October 14, 1986Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Richard M. Weier
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Patent number: 4578505Abstract: This invention relates to novel allenic prostanoic acid derivatives having the following formula ##STR1## wherein R is hydrogen; or straight or branched chain alkyl of 1 to 6 carbon atoms, inclusivewherein R.sub.1 is hydrogen; or straight or branched chain alkyl of 1 to 6 carbon atoms, inclusive; or vinyl (--CH.dbd.CH.sub.2)wherein R.sub.2 is straight or branched chain alkyl of 1 to 6 carbon atoms; or cycloalkyl group containing 3 to 6 carbon atoms; or phenyl; or phenoxywherein R.sub.3 is hydrogen; or straight chain alkyl of 1 to 3 carbon atomswherein m is an integer of from 1 to 4, inclusive,wherein n is an integer of from 1 to 3, inclusive with the proviso that the sum of m and n does not exceed 5,wherein y is an integer of from 1 to 3.These compounds are useful by reason of their gastric antisecretory and cytoprotective activity.Type: GrantFiled: September 4, 1984Date of Patent: March 25, 1986Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Richard M. Weier
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Patent number: 4536592Abstract: The present invention encompasses 16-alkyl, 16-hydroxy-2-substituted prostaglandins which exhibit cytoprotective and antisecretory activity with greatly reduced diarrhea side effects.Type: GrantFiled: February 16, 1984Date of Patent: August 20, 1985Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki, Richard M. Weier
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Patent number: 4529812Abstract: This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E.sub.2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypertensive activity. In addition the invention also discloses certain novel trialkylsilyl acetylenic intermediates.Type: GrantFiled: December 6, 1983Date of Patent: July 16, 1985Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Richard M. Weier
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Patent number: 4499296Abstract: This invention encompasses prostaglandins of the formula I ##STR1## wherein R'" represents hydroxymethyl, hydroxyacetyl or --CO.sub.2 R"" wherein R"" represents hydrogen or lower alkyl containing 1 to 6 carbon atoms;R' represents lower alkyl containing 1 to 6 carbon atoms, vinyl or ethynyl;R" represents cycloalkyl containing 3 to 5 carbon atoms; and the wavy line represents optional R,S stereochemistry.These compounds are potent antisecretory compounds and cytoprotective agents with reduced diarrhea side effects.Type: GrantFiled: November 14, 1983Date of Patent: February 12, 1985Assignee: G. D. Searle & Co.Inventors: Paul W. Collins, Alan F. Gasiecki