Abstract: A compound of the formula ##STR1## wherein R is hydrogen or lower alkyl having 1-7 carbon atoms; R', R", and R'" are each individually hydrogen or methyl; n is 0-3; and Ar is phenyl, halosubstituted phenyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1-4 carbon atoms, lower alkoxy substituted phenyl wherein the lower alkoxy contains 1-4 carbon atoms, p-biphenyl, or trifluoromethyl substituted phenyl. Compounds of the present invention are useful as antifertility agents.

Abstract: 4,5-Unsaturated 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g. gastric antisecretory, are described herein.

Abstract: .alpha. Diene 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g., gastric antisecretory, are described herein.

Abstract: 4,5-Unsaturated 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g. gastric antisecretory, are described herein.

Abstract: Compounds of the formula ##STR1## wherein R is phenyl cyclohexyl or lower alkyl containing 1-6 carbon atoms; R" is hydrogen or methyl; R'" is alkenyl or alkynyl having 3-5 carbon atoms; R' is hydrogen, tetrahydrofuran-2-yl tetrahydropyran-2-yl or trialkylsilyl wherein the alkyl contains 1-4 carbon atoms. Compounds of the present invention are useful in synthesizing prostaglandin like molecules which are active anti-secretory agents.

Abstract: The present invention encompasses compounds of the formula: ##STR1## wherein n is 0 or 1; Y represents ethylene or vinylene; R represents hydrogen or lower alkyl having 1-7 carbon atoms; R', R", R'" each individually represent hydrogen or methyl; Ar represents phenyl, halosubstituted phenyl, alkyl substituted phenyl wherein the alkyl contains 1-4 carbon atoms, alkoxy substituted phenyl wherein the alkoxy contains 1-4 carbon atoms, trifluoromethylphenyl, or biphenyl; and the wavy line indicates R or S stereochemistry.

Abstract: The present invention encompasses novel intermediates of the formula: ##STR1## wherein R is phenyl, cyclohexyl or lower alkyl having 1-6 carbon atoms; R' is trialkylsilyl wherein the alkyls have 1-4 carbon atoms, tetrahydropyran-2-yl, or tetrahydrofuran-2-yl; and R" is lower alkyl having 1 to 3 carbon atoms. Compounds of the present invention are useful in synthesizing prostaglandin-like molecules which are active anti-secretory agents.

Abstract: 7-{3-Hydroxy-2.beta.-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1.alpha.-yl}hept-5-cis-enoic acids, displaying valuable pharmacological properties, e.g., gastric anti-secretory, are produced by the reaction of 7-(3-oxygenated-5-oxocyclopent-1-en-1-yl)hept-5-cis-enoic acid or ester with the appropriate organometallic reagent.

Abstract: The present invention encompasses compounds of the formula: ##STR1## wherein one of A and B is methyl and the other is hydrogen, the wavy line represents R or S stereochemistry, n is 2-5, and R is hydrogen or lower alkyl having 1-7 carbon atoms.

Abstract: 7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl{heptanoic acids and esters, displaying valuable pharmacological properties, e.g., gastric anti-secretory, are produced by the reaction of a 7-(3-oxygenated-5-oxocyclopent-1-en-1-yl)heptanoic acid or ester with the appropriate organometallic reagent.

Abstract: 3-(Optionally oxygenated)-5-oxocyclopent-1-enealkanoic acids and their alkyl esters are allowed to react with appropriate alkenyl copper, alkenyl boron, alkynyl boron, alkynyl gallium or alkynyl aluminum compounds to produce the corresponding 2-(3-hydroxy-3-[optionally alkylated]-1-alkenyl)cyclopentanealkanoic acids, 2-(3-hydroxy-3-[optionally alkylated]-1-alkynyl)cyclopentanealkanoic acids and their esters. The prostaglandin derivatives so produced are valuable and useful as pharmacological agents as is evidenced by their central nervous system-affective, anti-bacterial, anti-fungal and prostaglandin antagonist activity.

Abstract: 16-Oxygenated prostanoic acid derivatives, displaying valuable pharmacological properties, e.g. gastric anti-secretory, are produced by reaction of an (optionally 3-oxygenated)-5-oxocyclopent-1-enealkanoic/alkenoic acid or ester with the appropriate organometallic reagent.