Abstract: Described herein are methods and compositions for the treatment of skin conditions associated the dysbiosis. Further described herein is the use of metabolites for treatment of dysregulated microbiota in a subject. Such metabolites can be produced by microorganisms present in a higher abundance in the skin of healthy subjects as compared to the skin of a subject having dysbiosis of the skin. In addition, compositions and methods provided herein describe the use of metabolites as part of a combination therapy.

Abstract: A method for processing radar data is described herein. In accordance with one embodiment, the method includes the calculation of a Range Map based on a digital radar signal received from a radar receiver. The Range Map includes spectral values for a plurality of discrete frequency values and a plurality of discrete time values, wherein each spectral value is represented by at least a first parameter. Further, the method includes applying an operation to at least the first parameters in the Range Map for at least one discrete frequency value to smooth or analyze at least a portion of the Range Map.

Abstract: A method includes: receiving, in a first tag, a first security certificate for a second tag and a session token corresponding to an arrangement involving the first and second tags; determining, by the first tag, that the second tag satisfies a proximity criterion with regard to the first tag; receiving, in the first tag and from the second tag, the first security certificate and the session token; and generating, by the first tag and in response to the determination and the receipt of the first security certificate and the session token, a first output corresponding to verification of a custodian of the second tag as a participant in the arrangement.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: This invention relates to a device for insertion of a deep-in-the-canal hearing aid—alternatively designatable as extended wear hearing aid—into an ear canal of an individual user, at a pre-determined insertion depth (d) thereof. The insertion device comprises a customized support comprising an outer profile conforming to the shapes of at least a portion of a conchal cavity and of an ear canal of said individual user; and a guide channel, disposed internal to said outer profile, extending between a lateral entry opening thereof, for loading said hearing aid; and a medial exit opening thereof, for releasing said hearing aid into said ear canal. The present invention also relates to a method of manufacturing an insertion device for inserting a hearing aid deep into an ear canal of an individual hearing aid user, at a pre-determined insertion depth (d) thereof.

Abstract: Systems and methods are described for implementing execution guarantees in an on-demand code execution system or other distributed code execution environment, such that the on-demand code execution system attempts to execute code only a desired number of times. The on-demand code execution system can utilize execution identifiers to distinguish between new and duplicative requests, and can decline to allocate computing resources for duplicative requests. The on-demand code execution system can further detect errors during execution, and rollback the execution to undo the execution's effects. The on-demand code execution system can then restart execution until the code has been execute the desired number of times.

Abstract: Techniques for monitoring user experience for cloud-based services, availed via an entity, are described. Server computing device(s) can receive, from a user device using a cloud-based service, data associated with component(s) of the user device, wherein the data is indicative of a user experience associated with the user device while using the cloud-based service. The server computing device(s) can monitor, using rule(s) and based at least partly on the data, changes to a state of the user device. The server computing device(s) can determine, based at least partly on the monitoring, an occurrence of a trigger event associated with a remedial action and can effectuate the remedial action. As a result, techniques described herein enable near real-time—and in some examples, automatic—reporting and/or remediation for preventing and/or correcting changes to the state of the user device that can cause poor user experiences.

Abstract: A method for operation of a central office point of delivery includes: in response to a pluggable interface module being plugged into an access node port of a line termination node of the central office point of delivery, transmitting, by the line termination node, a request message to a control node of the central office point of delivery, wherein the request message comprises interface module information related to the pluggable interface module, and wherein an activation clearance is requested, via the request message, from the control node; receiving, by the line termination node, from the control node, an acknowledgement message related to the activation clearance requested by the request message, wherein the acknowledgement message corresponds to a verification operation and/or activation clearance operation having been successful; and activating, by the line termination node and/or by the access port node, the pluggable interface module.

Abstract: An electronic device, an electronic module comprising the electronic device and methods for fabricating the same are disclosed. In one example, the electronic device includes a semiconductor substrate and a metal stack disposed on the semiconductor substrate, wherein the metal stack comprises a first layer, wherein the first layer comprises NiSi.

Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon agonist linker conjugate Z-L1-L2-L-Y—R20, wherein Y represents an GLP-1/Glucagon agonist moiety; and -L is a linker moiety—by formula (Ia), wherein the dashed line indicates the attachment to one of the amino groups of the GLP-1/Glucagon agonist moiety by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by GLP-1/Glucagon agonist.

Abstract: A household appliance includes a plug for electrical contacting. The plug includes a body for mechanically retaining an electrically conductive contact. A protective hood extends at least largely over the body and has a burning point which is higher than a burning point of a material of the body of the plug.

Abstract: The present invention relates to a conjugate or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon receptor agonist, a linker and a hyaluronic acid hydrogel bearing -L1-L2-L-Y—R20 groups, wherein Y represents an GLP-1/Glucagon receptor agonist moiety; and -L is a linker moiety—by formula (Ia), wherein the dashed line indicates the attachment to one of the amino groups of the GLP-1/Glucagon receptor agonist moiety by forming an amide bond. The invention further relates to pharmaceutical compositions comprising the conjugates as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by GLP-1/Glucagon receptor agonist.

Abstract: Hearing devices, configured to fit within the ear canal, having a hearing device core defining an exterior surface with a medial end and a medial corner, and including a battery, a microphone and a receiver, at least one seal, defining a seal compliance, carried on the hearing device core, and a medial bumper, defining a medial bumper compliance that is greater than the seal compliance, carried on the hearing device core.

Abstract: A system for integrating an endpoint management system and a virtual compute system is provided. The system may be configured to receive a first request to execute a proxy application programming interface (API) associated with a first resource of a plurality of resources maintained by the endpoint management system, determine, based at least in part on the first request and the proxy API, an API mapping definition associated with the proxy API, output a second request to execute a program code on the virtual compute system based on the API mapping definition associated with the proxy API, wherein the second request contains information associated with the first resource, receive a first response from the virtual compute system, wherein the first response contains information regarding the first resource, and output a second response based on the first response received from the virtual compute system.

Abstract: A planetary gearing includes a sun gear rotating about a rotation axis and driven by a sun shaft; planet gears driven by the sun gear; a ring gear engaging the planet gears; and a plurality of planet pins that respectively include an outer-side abutment surface having an axially forward end and an axially rearward end. Respectively, one planet pin is arranged inside a planet gear, and the planet pin and the planet gear form a lubricated journal bearing. At an axially forward face side and/or axially rearward face side, each planet gear forms a recess that extends inside the planet gear starting from the face side. The planet pins respectively form a crowning at their abutment surface such that their outer diameter decreases from a maximum outer diameter towards at least one axial end of the abutment surface, and has a minimum at the axial end.

Abstract: A vehicle axle includes, an axle gear unit housing and axle tubes adjoining the latter. The axle gear unit housing has an opening which is surrounded by a flange. Threaded blind bore holes extend beyond the thickness of the flange into the region of the wall of the axle gear unit housing which has radially outwardly on the side of the flange facing the axle gear unit housing a wall thickening which extends annularly radially circumferentially along the flange and which is configured in a continuously annular manner or so as to form spot faces partially in the areas of the threaded blind bore holes, wherein a joint flash extends in a central plane along the axle tubes and toward the flange 4 in the region of the axle gear unit housing and at the flange along the radially outer contour of the wall thickening.

Abstract: Disclosed herein are multi-bed rapid cycle pressure swing adsorption (RCPSA) processes for separating O2 from N2 and/or Ar, wherein the process utilizes at least five adsorption beds each comprising a kinetically selective adsorbent for O2 having an O2 adsorption rate (1/s) of at least 0.20 as determined by linear driving force model at 1 atma and 86° F.

Abstract: A grappling dummy having a generally human shape includes a trunk with a head, arms, and legs extending from the trunk. The legs can be connected together by a connecting leg segment forming a leg enclosure. The grappling dummy also includes padding disposed about the trunk, the head, the arms, and the legs. The trunk defines a midline, and the head can extend longitudinally from the trunk angled in a forward direction from the midline at about forty-five degrees. Each of the arms can extend from the trunk at about forty-five degrees. Each of the arms can lie in a generally transverse plane with respect to the midline. Each of the legs can extend from the trunk at about forty-five degrees. Each of the legs can lie in a second plane angled in a forward direction from the midline of the trunk at about forty-five degrees.

Abstract: An electronic device, an electronic module comprising the electronic device and methods for fabricating the same are disclosed. In one example, the electronic device includes a semiconductor substrate and a metal stack disposed on the semiconductor substrate, wherein the metal stack comprises a first layer, wherein the first layer comprises NiSi.

Abstract: A reamer head for a reamer includes one or more blades separated by flutes. Each flute has a front core region proximate a front end of the cutting portion, a rear portion proximate a rear end of the cutting portion and the middle core region therebetween. The front core region has a thickness, T1, the middle core region has a thickness, T2, and the rear core region has a thickness, T3. The thickness, T2, of the middle core region is greater than the thickness, T1, of the front core region and the thickness, T3, of the rear core region. A method of making the reamer head is also disclosed.