Patents by Inventor Paula J. Bates

Paula J. Bates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES
    Publication number: 20140220013
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Application
    Filed: October 21, 2013
    Publication date: August 7, 2014
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Paula J. Bates, Donald M. Miller, John Q. Trent, Xiaohua Xu
  • ANTI-NUCLEOLIN AGENT-CONJUGATED NANOPARTICLES
    Publication number: 20140170076
    Abstract: A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 1, 2012
    Publication date: June 19, 2014
    Applicant: THE UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC
    Inventors: Paula J. Bates, Mohammad Tariq Malik, Kyung A. Kang
  • Therapeutic compounds
    Patent number: 8703829
    Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: April 22, 2014
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Patent number: 8648051
    Abstract: The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: February 11, 2014
    Assignee: Advanced Cancer Therapeutics, LLC
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent
  • Method for the diagnosis and prognosis of malignant diseases
    Patent number: 8586717
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: November 19, 2013
    Assignee: University of Louisville Research Foundation, Inc
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • METHODS OF INCREASING MACROPINOCYTOSIS IN CANCER CELLS
    Publication number: 20130065227
    Abstract: This disclosure describes methods of stimulating macropinocytosis in cancer cells.
    Type: Application
    Filed: March 4, 2011
    Publication date: March 14, 2013
    Inventors: Paula J. Bates, Elsa Merit Reyes-Reyes
  • THERAPEUTIC COMPOUNDS
    Publication number: 20120329866
    Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Application
    Filed: May 23, 2012
    Publication date: December 27, 2012
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION
    Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
  • Therapeutic compounds
    Patent number: 8207381
    Abstract: The invention provides compounds of Formula (I): wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: June 26, 2012
    Assignee: University of Louisville Research Foundation
    Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Patent number: 8114850
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: February 14, 2012
    Assignee: Advanced Cancer Therapeutics, LLC
    Inventors: John O. Trent, Paula J. Bates, Donald J. Miller
  • METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES
    Publication number: 20120014942
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Application
    Filed: May 26, 2011
    Publication date: January 19, 2012
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • Method for the diagnosis and prognosis of malignant diseases
    Patent number: 8029784
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: October 4, 2011
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20110178161
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic; hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 21, 2011
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Patent number: 7960540
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 14, 2011
    Assignee: Advanced Cancer Therapeutics, LLC
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • METHOD FOR THE DETECTION OF APOPTOSIS
    Publication number: 20110065121
    Abstract: Methods for the detection of apoptosis by measuring apoptotic bodies shed by apoptotic cells are provided, as are kits to carry out such methods.
    Type: Application
    Filed: October 22, 2009
    Publication date: March 17, 2011
    Inventors: Paula J. Bates, Yingchang Mi
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20090326047
    Abstract: The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.
    Type: Application
    Filed: October 29, 2004
    Publication date: December 31, 2009
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent
  • METHODS AND PRODUCTS TO TARGET, CAPTURE AND CHARACTERIZE STEM CELLS
    Publication number: 20090226914
    Abstract: A method for identifying cancer stem cells, comprises reacting a plurality of cells comprising cancer stem cells with an anti-nucleolin agent to bind the anti-nucleolin agent to the cancer stem cells; and identifying the cancer stem cells that are bound to the anti-nucleolin agent from remaining cells of the plurality of cells.
    Type: Application
    Filed: December 29, 2008
    Publication date: September 10, 2009
    Inventors: Paula J. Bates, Enid Choi
  • Method for the diagnosis and prognosis of malignant diseases
    Patent number: 7541150
    Abstract: Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: June 2, 2009
    Assignee: University of Louisville Research Foundation, Inc
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent, Xiaohua Xu
  • METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES
    Publication number: 20090017009
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Application
    Filed: March 4, 2008
    Publication date: January 15, 2009
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318889
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318890
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller