Patents by Inventor Paula J. Bates

Paula J. Bates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318887
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
    Publication number: 20080318888
    Abstract: Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Antisoma Research Limited
    Inventors: John O. Trent, Paula J. Bates, Donald M. Miller
  • THERAPEUTIC COMPOUNDS
    Publication number: 20080188570
    Abstract: The invention provides compounds of Formula (I): wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Application
    Filed: February 6, 2008
    Publication date: August 7, 2008
    Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
  • Method for the diagnosis and prognosis of malignant diseases
    Patent number: 7357928
    Abstract: Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: April 15, 2008
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Paula J. Bates, Donald M. Miller, John O. Trent, Xiaohua Xu
  • Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
    Patent number: 7314926
    Abstract: The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin-like in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: January 1, 2008
    Assignee: Antisoma Research Limited
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent
  • Method for the detection of apoptosis
    Publication number: 20040132049
    Abstract: Methods for the detection of apoptosis by measuring apoptotic bodies shed by apoptotic cells are provided, as are kits to carry out such methods.
    Type: Application
    Filed: June 26, 2003
    Publication date: July 8, 2004
    Inventors: Paula J. Bates, Yingchang Mi
  • Method for the diagnosis and prognosis of malignant diseases
    Publication number: 20030194754
    Abstract: Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.
    Type: Application
    Filed: April 8, 2002
    Publication date: October 16, 2003
    Inventors: Donald M. Miller, Paula J. Bates, John O. Trent, Xiaohua Xu