Abstract: The invention relates to the fields of vaccines and vaccine adjuvants, and generally relates to polynucleotide adjuvants, polynucleotide vaccines and vaccine compositions. More specifically, the invention relates to said polynucleotides and vaccine compositions for use in inducing or enhancing a prophylactic or therapeutic immune response in a mammalian subject. Furthermore, it relates to said polynucleotides and vaccine compositions for use in the prophylactic or therapeutic treatment of an infectious disease, such as in the prophylactic or therapeutic treatment of leishmaniasis.

Abstract: A method 100 of determining a flow rate of a fluid flowing in a pipe. The method 100 includes measuring a pressure of fluid at least two locations in the pipe 101, the pressure being measured by sensors that are positioned on or in the pipe. A wave speed of fluid is determined 102 based on measured pressure of fluid at a location in the pipe. The flow rate of fluid is determined 106 based on the determined wave speed and based on the measured pressures at two locations in the pipe. An apparatus for determining a flow rate of fluid flowing in a pipe is configured to perform the method 100.

Abstract: Separating system for separating a support and a product arranged on the support. According to one embodiment the system includes conveying means adapted for receiving the product arranged on its support and for conveying the products in a first conveyance direction. The conveying means includes two product support elements separated from one another in at least one point by a width less than a width of the product (the width of the product being transverse to the first conveyance direction) and greater than the width of its support (with the width of the support being transverse to the first conveyance direction), such that the product is supported by, and conveyed on, the product support elements of the conveying means, and the support is separated from the product upon the product being supported on the product support elements.

Abstract: A package includes a first panel and a second panel, wherein each of the first and second panels defines a right side edge portion, a left side edge portion, a first end portion, and a second end portion. The package includes a pleat that interconnects between the first end portions of the first and second panels. The pleat defines a right side edge portion and a left side edge portion and includes a handle aperture forming a handle. A first seam joins the right side edge portions of the first panel, the second panel, and the pleat and a second seam joins the left side edge portions of the first panel, the second panel, and the pleat. A third seam joins the second end portion of the first panel with the second end portion of the second panel. The first panel, the second panel, and the pleat are integrally formed.

Abstract: Aspects of the present disclosure relate to a capillary fluidic device comprising at least two inlets, a microfluidic channel and an outlet. The device allows for the autonomous and programmable sequential flow of the same or different fluids using capillary fluidics for autonomous pumping of liquids to other downstream fluidic structures. External pumping and valving systems are not required, thus reducing complexity and increasing portability of stand-alone microfluidic systems. Aspects of the present disclosure can be applied to other fluidic structures for performing analytical biological assays. The integration has at least one reaction chamber and at least one capillary pump. The device is integrated with at least one sensor for detection and quantification of the biological assay signals.

Abstract: An offline semantic processor of a resource-constrained voice-enabled device such as a mobile device utilizes an offline grammar model with reduced resource requirements to parse voice-based queries. In various implementations, a query issued at a resource-constrained device may be semantically processed to identify candidate responsive actions that are performable by the resource-constrained device. Candidate responsive action performance statistics may be analyzed to select, from the one or more candidate responsive actions, a qualifying responsive action. In various implementations, the candidate responsive action performance statistics may relate to performance of the one or more candidate responsive actions by the resource-constrained device following issuance of the query.

Abstract: An offline semantic processor of a resource-constrained voice-enabled device such as a mobile device utilizes an offline grammar model with reduced resource requirements to parse voice-based queries. In various implementations, a query issued at a resource-constrained device may be semantically processed to identify candidate responsive actions that are performable by the resource-constrained device. Candidate responsive action performance statistics may be analyzed to select, from the one or more candidate responsive actions, a qualifying responsive action. In various implementations, the candidate responsive action performance statistics may relate to performance of the one or more candidate responsive actions by the resource-constrained device following issuance of the query.

Abstract: It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ?7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P<0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: The present invention provides for a mounting envelope (1) for receiving a curtain-airbag and for attaching the curtain-airbag to the interior of a vehicle, in particular to the roof frame of a vehicle. The mounting envelope (1) comprises a longitudinal tear-line (3) which is configured to break in the event of a curtain air-bag deployment and extends in a longitudinal direction (L) of the mounting envelope. The mounting envelope is characterized in that it covers at least a major part of a curtain-airbag and in that it comprises at least additional vertical tear-line (7), preferably extending in a direction (V) substantially perpendicular to the longitudinal direction (L).

Abstract: The present invention is based on the surprising discovery that the overexpression of the SCL gene, of nucleotide sequence SEQ ID NO: 1, increases the production of megakaryocytes and platelets from stem cells. Likewise, it has been proven that this increase also occurs using PSCs which, unlike CD34+ HSC cells which have a limited expansion capacity, are characterized by an unlimited growth capacity, and can result in the unlimited production of platelets for the use thereof in clinics.

Abstract: A high-speed railway aerodynamic sleeper (1) including one central area (2), two support areas (3) on each side of the central area (2), on which the rails are placed, and two outer areas (4), located at the ends of the sleeper (1), following the support areas (3). The cross-section of the sleeper (1) includes, on the central area (2), and the support areas (3), and the two outer areas (4), a first bottom section (5) comprising a first polygon (7) having at least 4 sides and a second top section (6) having at least one second polygon (8) of n sides, n being?4, the first bottom section (5) and the second top section (6) being attached to each other, and the top base (10) of the first polygon (7) and the bottom base (9) of the second polygon (8) share their sides.

Abstract: Systems and methods are disclosed for detecting compounds in a sample using a tandem mass spectrometer. A sample comprising a plurality of detectable compounds that have been separated in time over a time interval is introduced into a tandem mass spectrometer. A sample product ion spectra is obtained. The presence of one or more known compounds of interest in the sample product ion spectra is determined. A compound is identified as present in the sample if the score associated with said compound meets a threshold value set as indicative of the likely presence of the compound in the sample.

Abstract: The invention relates to an inflatable airbag (10) of a curtain airbag comprising an upper edge (11) and a lower edge (12), comprising a front side window portion (13) and a rear side window portion (14) as well as an inner layer (16) facing the interior compartment and an outer layer (16) facing the side windows (45). In accordance with the invention, the airbag (10) includes at least one mechanical reinforcing element (20, 20?) which in the inflated state of the airbag (10) is arranged to be spaced both from the upper edge (11) and from the lower edge (12) in a central area (17) of the height (H) of the airbag (10), the mechanical reinforcing element (20, 20?) being strip-shaped.

Abstract: Systems and methods are disclosed for quantitating detectable compounds of a sample. Sample product ion spectra are received for each mass selection window for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving the known product ion spectra from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectra, generating product ion traces in time for the sample product ion spectra for the known product ion spectra, calculating a score for the product ion traces and product ion spectra that represents how well known product ions and sample product ions match, and calculating a quantitative value for the known compound from the product ion traces when the score exceeds a threshold value.

Abstract: Systems and methods are disclosed for identifying detectable compounds of a sample. Sample product ion spectra are received for each mass selection window of precursor mass selection windows for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving a known product ion spectrum from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectrum, generating product ion traces in time for the retrieved sample product ion spectra, calculating a score for the product ion traces and the retrieved sample product ion spectra that represents how well the retrieved sample product ion spectra and the known product ion spectrum match, and confirming the identity of a precursor ion using the score.

Abstract: Dental implant having a body provided with an external thread and a head. The head has -at least a frustoconical outer portion with an increasing section, starting from the upper end of the head and having a tapering between 6° and 20° and a height between 0.5 mm and 2.0 mm; and a blind axial housing, in which there are defined: a frustoconical inner section, with a decreasing section, starting from the upper end of the head and having a tapering comprised between 15° and 30° and a height between 0.5 mm and 2.0 mm; a middle section for coupling an actuating tool; and a lower threaded section intended to receive an anchor screw of a dental prosthesis.

Abstract: Brake disc for vehicles comprising a set of through holes (8), each through hole (8) comprising in turn, a first diameter (ØM) and a second diameter (Øm), this second diameter (Øm) being lower than the first diameter (ØM). Furthermore, the through holes (8) comprise a first center (M) and a second center (m) of first diameter (ØM) and the second diameter (Øm), respectively, being offset from each other with respect to a perpendicular of the first friction surface (6.1), while the projection of the second diameter (Øm) being contained within the first diameter (ØM).

Abstract: Systems and methods are disclosed for quantitating detectable compounds of a sample. Sample product ion spectra are received for each mass selection window for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving the known product ion spectra from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectra, generating product ion traces in time for the sample product ion spectra for the known product ion spectra, calculating a score for the product ion traces and product ion spectra that represents how well known product ions and sample product ions match, and calculating a quantitative value for the known compound from the product ion traces when the score exceeds a threshold value.

Abstract: Systems and methods are disclosed for identifying detectable compounds of a sample. Sample product ion spectra are received for each mass selection window of precursor mass selection windows for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving a known product ion spectrum from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectrum, generating product ion traces in time for the retrieved sample product ion spectra, calculating a score for the product ion traces and the retrieved sample product ion spectra that represents how well the retrieved sample product ion spectra and the known product ion spectrum match, and confirming the identity of a precursor ion using the score.