Abstract: The invention proposes the photosensitized generation of nitric oxide (NO) from alanosine (3-(hydroxynitrosoamino)-D,L-alanine) by aluminum phthalocyanine tetrasulfonate (AlPcS4). While NO is obtained in nitrogen-saturated solutions, the invention proposes that both NO and peroxynitrite are produced in air-saturated solutions. Enhancement of NO production occurs in the presence of ubiquinone-0. The invention evidence that NO is produced by the photosensitized oxidation of alanosine. Both NO and peroxynitrite are detected during photoirradiation of AlPcS4 in the presence of 2-methyl-2-nitrosopropane (MNP) and hypoxanthine, but not in the absence of hypoxanthine, in air-saturated solutions, where HX is acting as sacrificial electron donor, thus promoting superoxide formation.

Abstract: The present invention provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes: multigene-family 360 genes 9L, 10L, 11L, 12L, 13L and 14L; and multigene-family 505 genes 1R, 2R, 3R and 4R. The invention further provides an attenuated African Swine Fever (ASF) virus which Lacks a functional version of the DP148R gene. The present invention also provides a vaccine comprising such an attenuated virus and its use to prevent ASF. Further, the invention relates to intranasal administration of an attenuated ASF virus.

Abstract: A specialized in-wall mounting apparatus encapsulates a virtualized hardware box and related electronic components in a uniquely-vertical and inverse orientation. The specialized in-wall mounting apparatus holds the virtualized hardware box vertically and inversely (i.e. upside down) with mounting brackets to position the front plate of the virtualized hardware box to face the ground, the rear plate to face up, and the body of the virtualized hardware box to be parallel to a vertical wall. Preferably, the specialized in-wall mounting apparatus is partially embedded in the vertical wall, with a carved-in section on the vertical wall. The apparatus may also optionally incorporate a thermal dissipation meshed screen front door.

Abstract: The present invention is concerned with a massage device having a drive unit for generating a translational back-and-forth movement of the applicator along a first axis having an amplitude of 0.2 mm to 1.5 mm. The amplitude can be varied between two different operation modes of the device.

Abstract: The present invention provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes: multigene-family 360 genes 9L, 10L, 11L, 12L, 13L and 14L; and multigene-family 505 genes 1R, 2R, 3R and 4R. The invention further provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the DP148R gene. The present invention also provides a vaccine comprising such an attenuated virus and its use to prevent ASF. Further, the invention relates to intranasal administration of an attenuated ASF virus.

Abstract: The present disclosure is concerned with epilator having an epilator head that has a head housing and a skin contacting unit arranged for being pivotable with respect to the head housing around a first axis and a handle arranged for being held by a user's hand, wherein the epilator head is pivotably connected with the handle and is arranged for being pivotable with respect to the handle around a second axis, the first axis and the second axis being essentially perpendicular to each other and the first axis and the second axis have a distance to each other.

Abstract: An epilating device having a frame, a pair of clamping elements with a first clamp and a second clamp mounted in the frame, wherein each clamp has a skin contact surface facing towards the user's skin. The first clamp and the second clamp being inclined with respect to each other in the open position and being parallel to each other in the closed position.

Abstract: The present disclosure is concerned with an attachment for an epilator or an epilator having an axle arranged for driven movement around a center axle axis, an end plate arranged at a first end of the axle for rotation together with the axle, the end plate having at least a first functional surface, a first clamping element having a functional surface, the first functional surface of the end plate being arranged face-to-face with the functional surface of the first clamping element, and the first clamping element being arranged for repeatedly being moved towards and away from the end plate such that repeatedly a closed position is obtained in which the two functional surfaces abut on each other, wherein the end plate is an outer part of the epilator or the attachment for an epilator.

Abstract: The present disclosure is concerned with an attachment for an epilator or an epilator having an axle arranged for driven movement around a center axle axis, an end plate arranged at a first end of the axle for rotation together with the axle, the end plate having at least a first functional surface, a first clamping element having a functional surface, the first functional surface of the end plate being arranged face-to-face with the functional surface of the first clamping element, and the first clamping element being arranged for repeatedly being moved towards and away from the end plate such that repeatedly a closed position is obtained in which the two functional surfaces abut on each other, wherein the end plate is an outer part of the epilator or the attachment for an epilator.

Abstract: A cosmetic device with an exchangeable application head and a device body is disclosed, wherein the device body contains a motor and drive mechanism, an actuating switch, a power supply, a head recognition element and a control element adapted to control the motor and drive mechanism based on an actuation of the actuation switch and the application head recognized by the head recognition element. It is provided that the head recognition element comprises at least one mechanical switch disposed on a carrier fixed at the device body. Further, a flexible actuation area is disposed in front of the at least one mechanical switch. The exchangeable application head has at least one recognition generating protrusion actuating through the flexible actuation area on one of the at least one mechanical switches when the exchangeable application head is mounted at the device body.

Abstract: The present invention is concerned with a massage device for the treatment of skin. The device comprises a body and an applicator for contacting the skin of a user. The applicator is mounted on the body. Further, a drive unit is provided for generating a translational back-and-forth movement of the applicator along a first axis having an amplitude of 0.2 mm to 1.5 mm. Finally, the amplitude can be varied between two different operation modes of the device.

Abstract: The present invention provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes: multigene-family 360 genes 9L, 10L, 11L, 12L, 13L and 14L; and multigene-family 505 genes 1R, 2R, 3R and 4R. The invention further provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the DP148R gene. The present invention also provides a vaccine comprising such an attenuated virus and its use to prevent ASF. Further, the invention relates to intranasal administration of an attenuated ASF virus.

Abstract: A bow and arrow hunting accessory device having a mounting post assembly with a sidewall, and mounting screws that insert into a tree. Further having a swivel bar assembly, and a mounting arm assembly with an accessory support arm to support a hunting bow. The mounting post assembly further has a shaft. The swivel bar assembly has a housing with a hole. The hole receives the shaft when the swivel bar assembly mounts onto the mounting post assembly. The swivel bar assembly has an elongated housing with extension holes. The mounting arm assembly has a mounting arm having an actuating pin. The elongated housing receives the mounting arm, and any of the extension holes receives the actuating pin. The mounting arm assembly has a wind vane. Further having a clamp assembly that secures an umbrella.

Abstract: The present disclosure provides compositions and methods for regulating gene expression via RNA-mediated silencing. The present disclosure also provides compositions and methods to optimize the processing of a dsRNA molecule into small RNA duplexes. The present disclosure further provides compositions and methods to improve the efficiency of a dsRNA molecule in producing desired small RNAs and promoting the silencing of a gene of interest.

Abstract: An epilator (100) comprising an epilating unit (1) for plucking and/or pulling hair (51) out of the skin (50) over an epilating width (E). Such an epilator is disadvantageous in that typically not all of the hairs are detected by the epilating unit (1) and some remain in the skin after the epilation. A subsequent epilation would then be required. In order to solve this problem, the epilator (100) has a hair removal unit (2) following the epilating unit (1) in the direction (B) of use, such that, in at least one operating mode, the hair removal unit (2) removes the hairs (51) that have not been pulled out by the epilating unit (1).

Abstract: The present disclosure is concerned with an attachment for an epilator or an epilator having an axle arranged for driven movement around a centre axle axis, an end plate arranged at a first end of the axle for rotation together with the axle, the end plate having at least a first functional surface, a first clamping element having a functional surface, the first functional surface of the end plate being arranged face-to-face with the functional surface of the first clamping element, and the first clamping element being arranged for repeatedly being moved towards and away from the end plate such that repeatedly a closed position is obtained in which the two functional surfaces abut on each other, wherein the end plate is an outer part of the epilator or the attachment for an epilator.

Abstract: The present disclosure is concerned with an attachment for an epilator or an epilator having an axle arranged for driven movement around a centre axle axis, an end plate arranged at a first end of the axle for rotation together with the axle, the end plate having at least a first functional surface, a first clamping element having a functional surface, the first functional surface of the end plate being arranged face-to-face with the functional surface of the first clamping element, and the first clamping element being arranged for repeatedly being moved towards and away from the end plate such that repeatedly a closed position is obtained in which the two functional surfaces abut on each other, wherein the end plate is an outer part of the epilator or the attachment for an epilator.

Abstract: The present disclosure is concerned with an attachment for an epilator or an epilator having an axle arranged for driven movement around a centre axle axis, an end plate arranged at a first end of the axle for rotation together with the axle, the end plate having at least a first functional surface, a first clamping element having a functional surface, the first functional surface of the end plate being arranged face-to-face with the functional surface of the first clamping element, and the first clamping element being arranged for repeatedly being moved towards and away from the end plate such that repeatedly a closed position is obtained in which the two functional surfaces abut on each other, wherein the end plate is an outer part of the epilator or the attachment for an epilator.

Abstract: An epilation device is proposed that has at least an epilation element having a skin side intended for contacting the skin in an operation state of the epilation device, the epilation element having at least two adjoining clamping elements that are arranged on a base structure and that each have a clamping surface so that the clamping surfaces lie opposite to each other, a support in which the epilation element is mounted, and an actuation arrangement that during operation of the epilation device repeatedly actuates the epilation element between a first bending state in which the base structure has a first curvature and a second bending state in which the base structure has a second curvature different to the first curvature, wherein the clamping surfaces the clamping elements are separated by a gap at the skin side in the first bending stage and are in clamping contact in the second bending stage.

Abstract: The present invention provides methods for assessing the responsiveness or sensitivity of a patient to bevacizumab, compositions comprising bevacizumab and methods of treating patients with bevacizumab.