Patents by Inventor Pei FAN
Pei FAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160362488Abstract: The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.Type: ApplicationFiled: April 15, 2016Publication date: December 15, 2016Inventors: Maria-Cristina LOOMIS, Leon F. Garcia-Martinez, Benjamin H. Dutzar, Daniel S. Allison, Lee Hendricks, Ethan W. Ojala, Pei Fan, Jeffrey T.L. Smith, John A. Latham, Charlie Karasek, Jenny Mulligan, Michelle Scalley-Kim, Erica Stewart, Vanessa Lisbeth Rubin, Jens J. Billgren
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Patent number: 9499611Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.Type: GrantFiled: December 1, 2011Date of Patent: November 22, 2016Assignee: ALDERBIO HOLDINGS LLCInventors: Benjamin H. Dutzar, Brian R. Kovacevich, Patricia Dianne McNeill, Danielle M. Mitchell, Ethan W. Ojala, Pei Fan, Jens Billgren, Erica A. Stewart, Corinne C. Akatsuka, Betty Yu-Ching Chang, John A. Latham, Leon F. Garcia-Martinez
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Publication number: 20160304604Abstract: The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.Type: ApplicationFiled: April 15, 2016Publication date: October 20, 2016Inventors: Maria-Cristina LOOMIS, Leon F. Garcia-Martinez, Benjamin H. Dutzar, Daniel S. Allison, Lee Hendricks, Ethan W. Ojala, Pei Fan, Jeffrey T.L. Smith, John A. Latham, Charlie Karasek, Jenny Mulligan, Michelle Scalley-Kim, Erica Stewart, Vanessa Lisbeth Rubin, Jens J. Billgren
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Publication number: 20160215049Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof.Type: ApplicationFiled: December 18, 2015Publication date: July 28, 2016Inventors: Andrew Lawrence Feldhaus, Leon F. Garcia-Martinez, Benjamin H. Dutzar, Daniel S. Allison, Katie Olson Anderson, Ethan Wayne Ojala, Pei Fan, Charlie Karasek, Jenny A. Mulligan, Danielle Marie Mitchell, Patricia Dianne McNeill, Michelle L. Scalley-Kim, Erica Stewart, Jeffrey T.L. Smith, John Latham
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Publication number: 20160071789Abstract: A method for forming a pass-through layer of an interposer of a packaged semiconductor device in which conducting structures are extended between first and second ends of a casing. The conducting structures are subsequently encapsulated in a molding compound to form a molded bar, and the molded bar is sliced to obtain the pass-through layer. The pass-through layer has conducting vias, each corresponding to a sliced section of one of the conducting structures. The cost of pass-through layers formed in this manner may be less than that of comparable silicon or glass pass-through layers.Type: ApplicationFiled: September 8, 2014Publication date: March 10, 2016Applicant: Freescale Semiconductor, Inc.Inventors: Pei Fan Tong, Boon Yew Low, Lan Chu Tan
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Patent number: 9255154Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.Type: GrantFiled: March 12, 2013Date of Patent: February 9, 2016Assignee: ALDERBIO HOLDINGS, LLCInventors: Andrew Lawrence Feldhaus, Leon F. Garcia-Martinez, Benjamin H. Dutzar, Ethan Wayne Ojala, Brian Robert Kovacevich, Katie Olson Anderson, Pei Fan, Jens Billgren, Erica Ann Stewart, Corinne C. Akatsuka, Patricia Dianne McNeill, Danielle Marie Mitchell, Dan Scott Allison, John A. Latham
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Patent number: 9196578Abstract: A semiconductor package has multiple dies and an interior power bar that extends within an interior space formed within the die flag between the dies. The bond pads located on the interior side of each die are wire-bonded to the interior power bar. Some embodiments may have more than two dies and/or more than one interior power bar between each pair of adjacent dies.Type: GrantFiled: August 14, 2014Date of Patent: November 24, 2015Assignee: FREESCALE SEMICONDUCTOR, INC.Inventors: Sheau Mei Lim, Meng Kong Lye, Pei Fan Tong
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Publication number: 20150329625Abstract: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.Type: ApplicationFiled: March 23, 2015Publication date: November 19, 2015Inventors: LEON F. GARCIA-MARTINEZ, JOHN A. LATHAM, ETHAN W. OJALA, CORINNE C. AKATSUKA, PEI FAN, JEFFREY T.L. SMITH, BENJAMIN H. DUTZAR
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Publication number: 20150306167Abstract: Disclosed herein is the use of an extract from Alpinia spp. for the preparation of a medicament for the treatment of irritable bowel syndrome (IBS). The extract is prepared by extracting fresh and/or dried fruits of Alpinia spp. plant with a solvent such as a supercritical fluid, water, 10-95% (v/v) ethanol, acetone, ethyl acetate or n-hexane, to obtain an extract suitable for the preparation of IBS medicaments. In some embodiments, active compounds with anti-abnormal defecation activity and/or analgesia effect are isolated from the water extract of Alpinia spp.; these compounds are therefore potential lead compounds for use as medicaments for treating IBS.Type: ApplicationFiled: December 30, 2013Publication date: October 29, 2015Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Jui-Ching CHEN, Che-Yi LIN, Chih-Sheng HUNG, Pei-Fan WU, Fen CHEN
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Publication number: 20150259414Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof.Type: ApplicationFiled: February 20, 2015Publication date: September 17, 2015Inventors: Andrew Lawrence FELDHAUS, Leon GARCIA-MARTINEZ, Benjamin H. DUTZAR, Daniel S. ALLISON, Katie Olson ANDERSON, Ethan Wayne OJALA, Pei FAN, Charlie KARASEK, Jenny MULLIGAN, Michelle SCALLEY-KIM, Erica STEWART, Jeffrey T.L. SMITH, John LATHAM
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Patent number: 9067988Abstract: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.Type: GrantFiled: March 15, 2013Date of Patent: June 30, 2015Assignee: ALDERBIO HOLDINGS LLCInventors: Leon F. Garcia-Martinez, John Latham, Ethan W. Ojala, Corinne C. Akatsuka, Pei Fan, Jeffrey T. L. Smith, Benjamin H. Dutzar
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Patent number: 8728473Abstract: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.Type: GrantFiled: December 1, 2011Date of Patent: May 20, 2014Assignee: Alderbio Holdings LLCInventors: Leon F. Garcia-Martinez, John A. Latham, Ethan W. Ojala, Corinne C. Akatsuka, Pei Fan, Jeffrey T. L. Smith, Benjamin H. Dutzar
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Publication number: 20140004116Abstract: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.Type: ApplicationFiled: March 15, 2013Publication date: January 2, 2014Inventors: Leon F. Garcia-Martinez, John A. Latham, Ethan W. Ojala, Corinne C. Akatsuka, Pei Fan, Jeffrey T.L. Smith, Benjamin H. Dutzar
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Publication number: 20130336975Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.Type: ApplicationFiled: March 15, 2013Publication date: December 19, 2013Inventors: Benjamin H. Dutzar, Brian R. Kovacevich, Patricia Dianne McNeill, Danielle M. Mitchell, Ethan W. Ojala, Pei Fan, Jens Billgren, Erica A. Stewart, Corinne C. Akatsuka, Betty Yu-Ching Chang, John A. Latham, Leon F. Garcia-Martinez
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Publication number: 20130302399Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.Type: ApplicationFiled: March 12, 2013Publication date: November 14, 2013Inventors: Andrew Lawrence Feldhaus, Leon F. Garcia-Martinez, Benjamin H. Dutzar, Ethan Wayne Ojala, Brian Robert Kovacevich, Katie Olson, Pei Fan, Jens Billgren, Erica Ann Stewart, Corinne C. Akatsuka, Patricia Dianne McNeill, Danielle Marie Mitchell, Dan Scott Allison, John A. Latham
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Patent number: 8430219Abstract: A power acquisition equipment, including at least: a power supplying portion, including at least: a pair of first posts, multiple second posts, multiple upper brackets, multiple lower brackets, multiple tightening devices, a cathode slide line, and an anode slide line, a power acquisition portion, including at least: a slide plate, a driving device, an adjusting device, a first base, and a linkage mechanism, and a control portion, including at least: a pair of front laser range sensors, a pair of back laser range sensors, multiple photoelectric detecting plates, a PLC controller, and an inverter driving system. The equipment features simple operation and high efficiency, and is retractable, stable, safe, cost-effective, and environmental friendly.Type: GrantFiled: December 26, 2009Date of Patent: April 30, 2013Assignees: Wuhan Guide Electric Co., Ltd., Wuhan Guide Electromechanical Engineering Co., Ltd., Chiwan Container Terminal Co., Ltd.Inventors: Aiguo Xiang, Haiming Xiong, Pei Fan
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Publication number: 20120148490Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.Type: ApplicationFiled: December 1, 2011Publication date: June 14, 2012Inventors: Benjamin H. Dutzar, Brian R. Kovacevich, Patricia Dianne NcNeill, Danielle M. Mitchell, Ethan W. Ojala, Pei Fan, Jens Billgren, Erica A. Stewart, Corinne C. Akatsuka, Betty Yu-Ching Chang, John A. Latham, Leon F. Garcia-Martinez
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Publication number: 20120141485Abstract: Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.Type: ApplicationFiled: December 1, 2011Publication date: June 7, 2012Inventors: Leon F. Garcia-Martinez, John A. Latham, Ethan W. Ojala, Corinne C. Akatsuka, Pei Fan, Jeffrey T.L. Smith, Benjamin H. Dutzar
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Publication number: 20110197609Abstract: A heat transfer system and method for maintaining or controlling a temperature of a device under test (DUT) with heat generating capability. The heat transfer system comprises a temperature control unit (TCU) for thermal coupling to the DUT, the TCU arranged for flow of a heat transfer medium therethrough; an automatic expansion valve disposed upstream of the TCU; a flow-regulating valve disposed downstream of the TCU; and a controller coupled to the TCU for receiving an input signal representative of a temperature of the DUT; wherein the controller is further coupled to the flow-regulating valve to change a flow area of the flow-regulating valve based on the signal representative of the temperature of the DUT.Type: ApplicationFiled: April 28, 2008Publication date: August 18, 2011Inventors: Kim Tiow Ooi, Yong Liang Teh, Tiew Toon Phay, Pei Fan Florence Ng
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Publication number: 20110011564Abstract: A heat transfer device for maintaining a temperature of a device under test with heat generating capability at a prescribed temperature, the heat transfer device comprising an inlet flow-duct; an outlet flow-duct; a conductor block comprising a plurality of through-holes, the through-holes receiving a fluid from the inlet flow-duct and delivering the fluid to the outlet flow-duct; and inserts disposed in the respective through-holes for reducing a cross-sectional area of the respective through-holes to improve heat transfer efficiency.Type: ApplicationFiled: December 7, 2007Publication date: January 20, 2011Inventors: Kim Tiow Ooi, Yong Liang Teh, Pei Fan Florence Ng, Tiew Toon Phay