Patents by Inventor Pei Huo
Pei Huo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170355743Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.Type: ApplicationFiled: November 19, 2015Publication date: December 14, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Songnian Lin, Lin Yan, Pei Huo, Dmitri Pissarnitski, Danqing Feng, Ravi Nargund, Yuping Zhu, Ahmet Kekec, Christina B. Madsen-Duggan, Zhi-Cai Shi, Zhicai Wu, Yingjun Mu
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Publication number: 20170107268Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.Type: ApplicationFiled: November 19, 2015Publication date: April 20, 2017Applicant: MERCK SHARP & DOHME CORP.Inventors: Songnian Lin, Lin Yan, Pei Huo, Dmitri Pissarnitski, Danqing Feng, Ravi Nargund, Yuping Zhu, Ahmet Kekec, Christina B. Madsen-Duggan, Zhi-Cai Shi, Zhicai Wu, Yingjun Mu
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Publication number: 20160303244Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.Type: ApplicationFiled: June 24, 2016Publication date: October 20, 2016Applicant: Merck Sharp & Dohme Corp.Inventors: Songnian Lin, Lin Yan, Ahmet Kekec, Yuping Zhu, David N. Hunter, Pei Huo, Danqing Feng, Ravi P. Nargund, Christopher R. Moyes, Zhiqiang Zhao, Brenda Pipik, Dmitri Pissarnitski, Joseph L. Duffy, Erin N. Guidry
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Publication number: 20160251407Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.Type: ApplicationFiled: October 2, 2014Publication date: September 1, 2016Applicant: Merck Sharp & Dohme Corp.Inventors: Songnian Lin, Lin Yan, Ahmet Kekec, Yuping Zhu, David N. Hunter, Pei Huo, Danqing Feng, Ravi P. Nargund, Christopher R. Moyes, Zhiqiang Zhao, Brenda Pipik, Dmitri Pissarnitski, Joseph L. Duffy, Erin Guidry
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Patent number: 9427475Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.Type: GrantFiled: October 2, 2014Date of Patent: August 30, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Songnian Lin, Lin Yan, Pei Huo
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Publication number: 20150105317Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.Type: ApplicationFiled: October 2, 2014Publication date: April 16, 2015Inventors: Songnian Lin, Lin Yan, Ahmet Kekec, Yuping Zhu, David N. Hunter, Pei Huo, Danqing Feng, Ravi P. Nargund, Christopher R. Moyes, Zhiqiang Zhao, Brenda Pipik, Dmitri Pissarnitski, Joseph L. Duffy, Erin N. Guidry
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Patent number: 8747587Abstract: A multi-layered material and a method for making the same are provided. The multi-layered material includes a first foamed layer, a substrate, a second foamed layer, and a surface layer. The first foamed layer has a plurality of first cells. The substrate is a fabric. The second foamed layer has a plurality of second cells. The foaming method of the second foamed layer is different from that of the first foamed layer. The size of the second cells is different from that of the first cells. The variation in size of the second cells is different from that of the first cells. The surface layer is disposed on the second foamed layer. Thus, when the multi-layered material is used as a surface cover of a ball, it can provide excellent resilience and control, and improve manufacturing efficiency.Type: GrantFiled: April 6, 2011Date of Patent: June 10, 2014Assignee: San Fang Chemical Industry Co., Ltd.Inventors: Chung-Chih Feng, Yung-Yu Fu, Kun-Lin Chiang, Jung-Ching Chang, Chih-Chenh Lin, Chun-Wei Wu, Pei-Huo Huang, I-Peng Yao
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Publication number: 20140147635Abstract: A composite coating material for covering an electronic device includes a surface layer with a surface pattern printed by a release paper, said surface layer being an outer layer of said composite coating material; structure layer made of polyurethane (PU) material, said structure layer being a middle portion of said composite coating material, and connected to said surface layer; substrate layer made of polyurethane (PU) material, said substrate layer being a lower layer of said composite coating material and connected to said structure layer.Type: ApplicationFiled: November 29, 2012Publication date: May 29, 2014Inventors: Chung-Ching Feng, I-Peng Yao, Pei-Huo Huang, Ko-Feng Wang, Yong-Song Lin, Kai-Feng Kang
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Patent number: 8623846Abstract: A compound having the structure (I) or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, deuterium, —OH, —OC1-6alkyl, or halogen; R8 is hydrogen, deuterium, or C1-6alkyl; R11 and R12 are independently hydrogen, —C1-6alkyl, —OH, —OC1-6alkyl, or halogen; R13 and R14 are independently —C1-6alkyl, —(CH2)1-2OH, or —OC1-6alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or —C1-6alkyl; R15 is —C(O)OH, —C(O)OCH2CH2N+CH3)3 wherein n is 0, 1 or 2, —C(O)NHCH(R17)OR16, or —C(O)NHCH(R17)C(O)NHCH(R18)C(O)OR16; R16 is hydrogen, C1-6alkyl, or (CH2)1-2N+R19R20R21; R1, R2, R4, R5, R6, R7, R9, R10, R17, R18, R19, R20, and R21 are independently hydrogen or —C1-6alkyl; and stereoisomers thereof, and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts of stereoisomers thereof.Type: GrantFiled: May 16, 2011Date of Patent: January 7, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Lin Yan, Pei Huo, Ravi Nargund
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Publication number: 20130059823Abstract: A compound having the structure (I) or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, deuterium, —OH, —OC1-6alkyl, or halogen; R8 is hydrogen, deuterium, or C1-6alkyl; R11 and R12 are independently hydrogen, —C1-6alkyl, —OH, —OC1-6alkyl, or halogen; R13 and R14 are independently —C1-6alkyl, —(CH2)1-2OH, or —OC1-6alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or —C1-6alkyl; R15 is (CR1R2)nC(O)OR16, wherein n is 0, 1 or 2, —C(O)NHCH(R17)OR16, or —C(O)NHCH(R17)C(O)NHCH(R18)C(O)OR16; R16 is hydrogen, C1-6alkyl, or (CH2)1-2N+R19R20R21; R1, R2, R4, R5, R6, R7, R9, R10, R17, R18, R19, R20, and R21 are independently hydrogen or —C1-6alkyl; and stereoisomers thereof, and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts of stereoisomers thereof.Type: ApplicationFiled: May 16, 2011Publication date: March 7, 2013Inventors: Amjad Ali, Lin Yan, Pei Huo, Ravi Nargund
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Patent number: 8354394Abstract: A compound having the structure (I) wherein R is selected from the group consisting of 1) and 2), or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.Type: GrantFiled: October 22, 2010Date of Patent: January 15, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Christopher Franklin, Ravi Nargund, Michael Man-Chu Lo, Lin Yan, Pei Huo
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Publication number: 20120234479Abstract: The production method of the coating material comprising the steps of applying and drying liquid polyurethane (PU) material onto a release paper in order to form three polyurethane (PU) layers, rolling the composite layer and separating the release paper to form the composite coating material for covering the outer shells of electronic devices. The polyurethane (PU) composite coating material thereby produced comprises at least a colored surface layer and a substrate layer. The surface of the composite coating material is colored and has a relief-like pattern, which can provide users with a better visual or touch effect.Type: ApplicationFiled: May 28, 2012Publication date: September 20, 2012Inventors: Chung-Ching Feng, I-Peng Yao, Pei-Huo Huang, Ko-Feng Wang, Yong-Song Lin, Kai-Feng Kang
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Publication number: 20120208838Abstract: A compound having the structure (I) wherein R is selected from the group consisting of 1) and 2), or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.Type: ApplicationFiled: October 22, 2010Publication date: August 16, 2012Inventors: Amjad Ali, Christopher Franklin, Ravi Nargund, Michael Man-Chu Lo, Lin Yan, Pei Huo
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Patent number: 8119806Abstract: A compound having the structure wherein X is selected from the group consisting of: a bond, —NHCH2(CH2)nCH2OC(O)—, —CH2NHC(O)CH2NHC(O)—, —CH2OC(O)—, —OCH(CH3)OC(O)—, —OCH2OC(O)—, —O—, —NR1—, —CR1R3—, —(CH2)p—, —(CH2)qNR1C(O)—, —CHR5NR2C(O)—, —(CH2)qC(O)—, —(CH2)qC(O)NR1—, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.Type: GrantFiled: July 27, 2009Date of Patent: February 21, 2012Assignee: Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Iyassu K. Sebhat, Christopher L. Franklin, Kathleen M. Rupprecht, Robert K. Baker, Ravi P. Nargund, Lin Yan, Pei Huo, Dong-Ming Shen, Nicoletta Almirante, Stefano Biondi, Massimiliano Ferrario, Alessia Nicotra
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Publication number: 20120021662Abstract: The present invention relates to a laminated material and a method for making the same. The laminated material includes a main layer, a surface layer and an adhesion layer. The main layer at least includes a first polymer resin. The surface layer is disposed on the main layer, the material of the surface layer is a second polymer resin, and the solid content of the second polymer resin is less than that of the first polymer resin. The adhesion layer is disposed under the main layer, and the material of the adhesion layer is thermoplastic resin which is adhesive when being heated, so that the laminated material can be directly attached to another element, thereby simplifying the process and reducing cost.Type: ApplicationFiled: June 28, 2011Publication date: January 26, 2012Applicant: SAN FANG CHEMICAL INDUSTRY CO., LTD.Inventors: CHUNG-CHIH FENG, YUNG-YU FU, KUN-LIN CHIANG, JUNG-CHING CHANG, CHIH-CHENH LIN, CHUN-WEI WU, PEI-HUO HUANG, I-PENG YAO
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Publication number: 20110250811Abstract: A multi-layered material and a method for making the same are provided. The multi-layered material includes a first foamed layer, a substrate, a second foamed layer, and a surface layer. The first foamed layer has a plurality of first cells. The substrate is a fabric. The second foamed layer has a plurality of second cells. The foaming method of the second foamed layer is different from that of the first foamed layer. The size of the second cells is different from that of the first cells. The variation in size of the second cells is different from that of the first cells. The surface layer is disposed on the second foamed layer. Thus, when the multi-layered material is used as a surface cover of a ball, it can provide excellent resilience and control, and improve manufacturing efficiency.Type: ApplicationFiled: April 6, 2011Publication date: October 13, 2011Applicant: SAN FANG CHEMICAL INDUSTRY CO., LTD.Inventors: CHUNG-CHIH FENG, YUNG-YU FU, KUN-LIN CHIANG, JUNG-CHING CHANG, CHIH-CHENH LIN, CHUN-WEI WU, PEI-HUO HUANG, I-PENG YAO
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Patent number: 7999107Abstract: Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia.Type: GrantFiled: January 16, 2008Date of Patent: August 16, 2011Assignee: Merck Sharp & Dohme Corp.Inventors: John S. Debenham, Jeffrey J. Hale, Pei Huo, Christina B. Madsen-Duggan, Thomas F. Walsh, Lin Yan
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Publication number: 20100029678Abstract: A compound having the structure wherein X is selected from the group consisting of: a bond, —NHCH2(CH2)nCH2OC(O)—, —CH2NHC(O)CH2NHC(O)—, —CH2OC(O)—, —OCH(CH3)OC(O)—, —OCH2OC(O)—, —O—, —NR1—, —CR1R3—, —(CH2)p—, —(CH2)qNR1C(O)—, —CHR5NR2C(O)—, —(CH2)qC(O)—, —(CH2)qC(O)—, —(CH2)qC(O)NR1—, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating, hypertension.Type: ApplicationFiled: July 27, 2009Publication date: February 4, 2010Inventors: Amjad ALI, Iyassu K. Sebhat, Cristopher L. Franklin, Kathleen M. Rupprecht, Robert K. Baker, Ravi P. Nargund, Lin Yan, Pei Huo, Dong-Ming Shen, Nicoletta Almirante, Stefano Biondi, Massimiliano Ferrario, Alessia Nicotra
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Patent number: 7605171Abstract: The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.Type: GrantFiled: December 13, 2004Date of Patent: October 20, 2009Assignee: Merck & Co., Inc.Inventors: Vincent J. Colandrea, George A. Doherty, Jeffrey J. Hale, Pei Huo, Irene E. Legiec, Leslie Toth, Petr Vachal, Lin Yan
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Publication number: 20090258136Abstract: The production method of the coating material comprising the steps of applying and drying liquid polyurethane (PU) material onto a release paper in order to form three polyurethane (PU) layers, rolling the composite layer and separating the release paper to form the composite coating material for covering the outer shells of electronic devices. The polyurethane (PU) composite coating material thereby produced comprises at least a colored surface layer and a substrate layer. The surface of the composite coating material is colored and has a relief-like pattern, which can provide users with a better visual or touch effect.Type: ApplicationFiled: June 18, 2009Publication date: October 15, 2009Inventors: Chung-Ching Feng, I-Peng Yao, Pei-Huo Huang, Ko-Feng Wang, Yong-Song Lin, Kai-Feng Kang