Abstract: Disclosed are a nanopore-optical electronic device and a method for sequencing a biomolecule and modifications thereof. The nanopore-optical electronic device includes: a cis-fluidic chamber and a trans-fluidic chamber fabricated in a planar substrate; a nano-fluidic channel in between and connecting the cis-fluidic chamber and the trans-fluidic chamber; a first electrode and a second electrode sealed in the nano-fluidic channel and forming a nanogap/nanopore therebetween; a third electrode and fourth electrode disposed in the cis-fluidic chamber and the trans-fluidic chamber, respectively; an optical coupling element coupling an electromagnetic beam with the nanogap; an optical detector detecting an optical signal from the nanogap when a biomolecule translocates through the nanopore; and a current-measuring circuit concurrently measuring a tunneling current and ionic current when the biomolecule translocates through the nanopore.

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer.

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of L1 and L2.

Abstract: This invention is related to a nanogap device for the electronic sensing of biomolecules.

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising atop surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.

Abstract: This invention provides a device and assays for the detection of pathogens.

Abstract: The present disclosure relates to a device, system and method for sensing functional motions of a single protein molecule via direct attachment of one or more electrodes to the molecule. The present disclosure also relates to an array, a system comprising an array and method for sequencing a biopolymer using an array.

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

Abstract: Provided herein, in one aspect, is an improved nanotrain for use in connection with a nanopore device for single-molecule detection. Methods for making and using the same are also provided.

Abstract: The present disclosure relates to a device, system and method for sensing functional motions of a single protein molecule via direct attachment of one or more electrodes to the molecule. The present disclosure also relates to an array, a system comprising an array and method for sequencing a biopolymer using an array.

Abstract: This disclosure provides, in one aspect, a platform and related methods to detect diagnostic markers or biomarkers for various diseases. In some embodiments, the platform can be a lateral flow test strip having a hydrogel composition deposited on one or more test zones.

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

Abstract: The present invention is related to engineered nucleic acid bases for use in molecular electronics, such as nanosensors, molecular-scale transistors, FET devices, molecular motors, logic and memory devices, and nanogap electronic measuring devices for the identification and/or sequencing of biopolymers.

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

Abstract: The present invention provides methods to engineer enzymes for their integration into a molecular nanowire as a fum-tional component for biopolymer sequencing/identification. The enzymes include but are not limited to DNA polymerase, RNA poly-merase, DNA helicase, DNA ligase, DNA exonuclease, reverse transcriptase, RNA primase, ribosome, sucrase, or lactase, which are either natural, mutated, or synthesized.

Abstract: The present invention relates to methods for creating conductive nanojunctions using metalized or conductive polymer joined to a DNA nanowire in a nanodevice for chemosensing and biosensing.

Abstract: The present invention relates to a nanopore device with a motion control mechanism to control the speed of a polymeric molecule translocating through the nanopore for a tunneling nanogap to read out its sequences or components.

Abstract: This invention provides methods to identify or sequence a DNA or RNA molecule electronically in a single molecule level based on polymerase synthesis.

Abstract: This invention provides a device for sequencing and identification of biopolymers electronically.

Abstract: This invention provides a nanostructure device and method for the sequencing or identification of biomolecules based on in vitro template-directed enzymatic replication or synthesis.