Patents by Inventor Peizhi Luo

Peizhi Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8030469
    Abstract: The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: October 4, 2011
    Assignee: SBI Incubation Co., Ltd.
    Inventors: Teikichi Aoyagi, Peter Peizhi Luo, Pingyu Zhong, Mark Hsieh, Yan Li, Kevin Caili Wang, Chikao Morimoto
  • Publication number: 20110124528
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 26, 2011
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Patent number: 7667004
    Abstract: Methods are provided for designing and selecting antibodies against human antigens with high affinity and specificity in silico and in vitro. In some particular embodiments, methods are provided for designing and selecting humanized or fully human antibodies against vascular endothelial growth factor (VEGF) with high affinity and specificity. In another aspect of the invention, monoclonal antibodies against VEGF are provided. In particular, humanized or human anti-VEGF monoclonal antibodies are provided with ability to bind to human VEGF with high affinity, inhibit VEGF-induced proliferation of endothelial cells in vitro and inhibit VEGF-induced angiogenesis in vivo. These antibodies and their derivative can be used in a wide variety of applications such as diagnosis, prevention, and treatment of diseases such as cancer, AMD, diabetic retinopathy, and other diseases derived from pathological angiogenesis.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: February 23, 2010
    Assignee: Abmaxis, Inc.
    Inventors: Pingyu Zhong, Peizhi Luo, Kevin C. Wang, Mark Hsieh, Yan Li
  • Publication number: 20090163379
    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.
    Type: Application
    Filed: November 14, 2008
    Publication date: June 25, 2009
    Inventors: Kevin Caili Wang, Peter Peizhi Luo, Pingyu Zhong, Jian Wang
  • Publication number: 20090136523
    Abstract: The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
    Type: Application
    Filed: November 3, 2008
    Publication date: May 28, 2009
    Applicant: Y's Therapeutics Co, Ltd.
    Inventors: Teikichi Aoyagi, Peter Peizhi Luo, Pingyu Zhong, Mark Hsieh, Yan Li, Kevin Caili Wang, Chikao Morimoto
  • Publication number: 20090082221
    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for multi-species and cross-species display of polypeptides on the outer surface of prokaryotic genetic packages and/or eukaryotic host cells. The multi-species and cross-species display systems can be practiced using the vector sets of the invention without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of phage, bacterial host cells, yeast cells, and mammalian cells.
    Type: Application
    Filed: May 3, 2007
    Publication date: March 26, 2009
    Inventors: Kevin Caili Wang, Pingyu Zhong, Peter Peizhi Luo
  • Patent number: 7462698
    Abstract: The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: December 9, 2008
    Assignee: Y's Therapeutics Co., Ltd.
    Inventors: Teikichi Aoyagi, Peter Peizhi Luo, Pingyu Zhong, Mark Hsieh, Yan Li, Kevin Caili Wang, Chikao Morimoto
  • Patent number: 7429652
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: September 30, 2008
    Assignee: Abmaxis, Inc.
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Patent number: 7208473
    Abstract: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: April 24, 2007
    Assignee: Xencor, Inc.
    Inventors: Bassil I. Dahiyat, Peizhi Luo
  • Publication number: 20070037214
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: August 10, 2006
    Publication date: February 15, 2007
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Publication number: 20070037217
    Abstract: The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as antibodies with high binding affinity and low immunogenicity in humans. In one embodiment, a method is provided for constructing a library of antibody sequences based on a three dimensional structure of a lead antibody.
    Type: Application
    Filed: August 17, 2006
    Publication date: February 15, 2007
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang
  • Patent number: 7144987
    Abstract: The invention relates to novel proteins with TNF-receptor antagonist activity and nucleic acids encoding these proteins. The invention further relates to TNF-receptor proteins with reduced immunogenicity and the use of these novel proteins in the treatment of TNF related disorders.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: December 5, 2006
    Assignee: Xencor
    Inventors: Arthur J. Chirino, Peizhi Luo, Peter Colon McDonnell, Umesh Muchhal, Malu Lourdes Tansey
  • Patent number: 7117096
    Abstract: The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as antibodies with high binding affinity and low immunogenicity in humans. In one embodiment, a method is provided for constructing a library of antibody sequences based on a three dimensional structure of a lead antibody.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: October 3, 2006
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang
  • Publication number: 20050148001
    Abstract: Methods and systems are provided for constructing recombinant antibody libraries based on three-dimensional structures of antibodies from various species including human. In one aspect, a library of antibodies with diverse sequences is efficiently constructed in silico to represent the structural repertoire of the vertebrate antibodies. Such a functionally representative library provides a structurally diverse and yet functionally more relevant source of antibody candidates which can then be screened for high affinity binding to a wide variety of target molecules, including but not limited to biomacromolecules such as protein, peptide, and nucleic acids, and small molecules.
    Type: Application
    Filed: November 22, 2004
    Publication date: July 7, 2005
    Inventors: Peizhi Luo, Mark Hsieh
  • Patent number: 6864359
    Abstract: The invention relates to novel non-naturally occurring cell surface receptor analogs, ligand analogs and nucleic acids encoding them. The invention further provides methods for screening of ligand analogs and bioactive agents capable of modulating the signaling activity of a non-naturally occurring cell surface receptor analog or capable of binding to a non-naturally occurring cell surface receptor analog.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: March 8, 2005
    Assignee: Xencor
    Inventor: Peizhi Luo
  • Publication number: 20050009139
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Application
    Filed: August 3, 2004
    Publication date: January 13, 2005
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Patent number: 6833441
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: December 21, 2004
    Assignee: Abmaxis, Inc.
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Publication number: 20040133357
    Abstract: Methods are provided for designing and selecting antibodies against human antigens with high affinity and specificity in silico and in vitro. In some particular embodiments, methods are provided for designing and selecting humanized or fully human antibodies against vascular endothelial growth factor (VEGF) with high affinity and specificity. In another aspect of the invention, monoclonal antibodies against VEGF are provided. In particular, humanized or human anti-VEGF monoclonal antibodies are provided with ability to bind to human VEGF with high affinity, inhibit VEGF-induced proliferation of endothelial cells in vitro and inhibit VEGF-induced angiogenesis in vivo. These antibodies and their derivative can be used in a wide variety of applications such as diagnosis, prevention, and treatment of diseases such as cancer, AMD, diabetic retinopathy, and other diseases derived from pathological angiogenesis.
    Type: Application
    Filed: November 26, 2003
    Publication date: July 8, 2004
    Applicant: Abmaxis, Inc.
    Inventors: Pingyu Zhong, Peizhi Luo, Kevin C. Wang, Mark Hsieh, Yan Li
  • Publication number: 20040096945
    Abstract: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
    Type: Application
    Filed: August 1, 2003
    Publication date: May 20, 2004
    Inventors: Bassil I. Dahiyat, Peizhi Luo
  • Publication number: 20040010376
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: May 20, 2003
    Publication date: January 15, 2004
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu