Patents by Inventor Peizhi Luo

Peizhi Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6627186
    Abstract: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: September 30, 2003
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Peizhi Luo
  • Publication number: 20030054407
    Abstract: Methods and systems are provided for constructing recombinant antibody libraries based on three-dimensional structures of antibodies from various species including human. In one aspect, a library of antibodies with diverse sequences is efficiently constructed in silico to represent the structural repertoire of the vertebrate antibodies. Such a functionally representative library provides a structurally diverse and yet functionally more relevant source of antibody candidates which can then be screened for high affinity binding to a wide variety of target molecules, including but not limited to biomacromolecules such as protein, peptide, and nucleic acids, and small molecules.
    Type: Application
    Filed: April 17, 2002
    Publication date: March 20, 2003
    Inventor: Peizhi Luo
  • Publication number: 20030027247
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Application
    Filed: August 1, 2001
    Publication date: February 6, 2003
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Publication number: 20030022240
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human. In one embodiment, a method is provided for constructing a library of antibody sequences based on the amino acid sequence of a lead antibody.
    Type: Application
    Filed: May 20, 2002
    Publication date: January 30, 2003
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Publication number: 20020177170
    Abstract: The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as antibodies with high binding affinity and low immunogenicity in humans. In one embodiment, a method is provided for constructing a library of antibody sequences based on a three dimensional structure of a lead antibody.
    Type: Application
    Filed: May 20, 2002
    Publication date: November 28, 2002
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang