Abstract: An anti-CTLA4 (cytotoxic T lymphocyte associated antigen 4) and anti-PD-1 (programmed cell death 1) bifunctional antibody. a pharmaceutical composition thereof and use thereof. Particularly, the anti-CLTA4 and anti-PD-1 bifunctional antibody comprises a first protein functional domain that targets PD-1 and a second protein functional domain that targets CTLA-4. The bifunctional antibody can bind to CTLA-4 and PD-1 specifically, relieve immunosuppression of CTLA4 and PD-1 on an organism specifically, activate T lymphocytes, and thus has good application prospects.

Abstract: Embodiments of the present disclosure relate to a method, system and computer program product for semantic search based on a graph database. In some embodiments, a method is disclosed. According to the method, the user jobs of a user are obtained from a first software product. Based on the user jobs, target test cases are selected from a plurality of test cases associated with the first software product and a second software product. The target test cases are applied to the first software product and the second software product, and in accordance with a determination that a result of applying the target test cases satisfies a predetermined criterion, an instruction is provided to indicate migrating from the first software product to the second software product. In other embodiments, a system and a computer program product are disclosed.

Abstract: A signal transmission method and a communication apparatus, to resolve a problem that an analog beam configuration switching process affects receiving and sending of a normal signal. The method includes: a terminal device receives first information from a network device, where the first information is used to schedule a first time domain resource and a second time domain resource, the first time domain resource is used to carry a first-type signal, the second time domain resource is used to carry a second-type signal, and a first beam configuration of the first-type signal is different from a second beam configuration of the second-type signal. The terminal device sends or receives a signal based on the first information, where the second-type signal is carried on a time domain resource other than N time domain units before and/or after the first time domain resource.

Abstract: A turbine engine gas-inlet cooling system and a turbine engine apparatus are disclosed. The turbine engine includes a gas-inlet end and a gas-outlet end, and the turbine engine gas-inlet cooling system includes a gas-inlet cooling device. The gas-inlet cooling device includes a gas-input end and a gas-output end, and is configured to cool working gas being input from the gas-input end. The gas-output end is connected with the gas-inlet end of the turbine engine.

Abstract: A three-dimensional memory device includes an alternating stack of insulating layers and electrically conductive layers located over a substrate, an array of memory opening fill structures located within an array of memory openings vertically extending through the alternating stack, and a drain-select-level isolation structure vertically extending through drain-select-level electrically conductive layers between two rows of memory opening fill structures. The drain-select-level isolation structure may comprise a low-k dielectric material or an air gap.

Abstract: Display panel and display device are provided. The display panel includes a display area and a non-display area. The display panel includes a plurality of first subpixels on the substrate. A first subpixel of the plurality of first subpixels includes a first pixel circuit and a light-emitting element electrically connected to the first pixel circuit. The first pixel circuit at least includes a first type of double-gate transistor. A first gate of the first type of double-gate transistor is connected to a first control line. A second gate of the first type of double-gate transistor is connected to a second control line. The display panel further includes a second detection line having a same width as the second control line.

Abstract: An ant-TIGIT antibody, and a pharmaceutical composition and the use thereof. The present invention relates to an anti-TIGIT antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region of the antibody comprises HCDR1-HCDR3 having amino acid sequences as shown in SEQ ID NOs: 3-5, respectively; and a light chain variable region of the antibody comprises LCDR1-LCDR3 having amino acid sequences as shown in SEQ ID NOs: 8-10, respectively. The antibody can effectively bind to TIGIT and has the potential for use in tumor prevention and treatment.

Abstract: Computer technology for protecting data security in a computerized system for recommending content to users where, a processing unit generates an identifier for a first data record relating to a user device based on a first machine learning model. Then, the processing unit sends the identifier to a service provider, and the service provider uses the identifier to determine one or more contents to be sent to the user device. Creating and using a decision tree machine learning (ML) model and a cluster ML model with training records and a transformed records.

Abstract: A method for extracting spatial resolution and/or velocity resolution of a single-input single-output radar acquiring raw radar data with a frequency scanning antenna is provided. The method includes steering a radar beam with the aid of the frequency scanning antenna with respect to an area to be illuminated by the radar, and dividing the area into at least two angular sectors. In this context, the at least two angular sectors are configured in a manner that the at least two angular sectors overlap with respect to each other.

Abstract: A storage system includes a management node and multiple storage nodes. Each storage node includes a first storage device of a first type (e.g., DRAM) and a second storage device of a second type (e.g., SCM), and a performance level of the first storage device is higher than the second storage device. The management node creates a globe cache including a first tier comprising the first storage device in each storage node, and a second tier comprising the second storage device in each storage node. The first tier is for storing data with a high access frequency, and the second tier is for storing data with a low access frequency. The management node monitors an access frequency of target data stored in the first tier. When the access frequency of the target data is lower than a threshold, the management node instructs the first storage node to migrate the target data from the first tier to the second tier of the globe cache.

Abstract: The present disclosure relates to a radio frequency power amplifier (RFPA) control device. The RFPA control device may include an input signal processing module configured to process an input signal into two signals. A first signal may be used for signal detection, and a second signal may be used for signal amplification. The RFPA control device may also include a delay module. The delay module may be disposed between the input signal processing module and an adjustment module. The delay module may be configured to determine a delay of the second signal such that the second signal and the control signal roughly simultaneously reach the adjustment module.

Abstract: The present disclosure discloses a method for synthesizing a speech. The method includes generating the speech based on a text with a speech synthesis model, wherein the speech synthesis model includes an embedding layer, a speech synthesis layer, and a position layer; and training the speech synthesis model when an evaluation index meets a preset condition, wherein the evaluation index includes one or more quality indexes determined based on at least a part of the text and at least a part of the speech.

Abstract: Display panel and display device are provided. The display panel includes an array substrate and a cover plate disposed opposite to the array substrate, touch electrode layers on a side of the cover plate facing the array substrate, and a plurality of first touch pads and a plurality of second touch pads disposed opposite to the plurality of the first touch pads. Each of the array substrate and the cover plate include a display area and a non-display area at least partially surrounding the display area. The non-display area of the array substrate includes a step area provided with bonding pads. The non-display area of the array substrate includes at least one irregularly-shaped area adjacent to the step area. A first touch pad is electrically connected to a second touch pad.

Abstract: Display panel and display device are provided. The display panel includes a display area and a non-display area. The display panel includes a plurality of first subpixels on the substrate. A first subpixel of the plurality of first subpixels includes a first pixel circuit and a light-emitting element electrically connected to the first pixel circuit. The first pixel circuit at least includes a first type of double-gate transistor. A first gate of the first type of double-gate transistor is connected to a first control line. A second gate of the first type of double-gate transistor is connected to a second control line. The display panel further includes a second detection line having a same width as the second control line.

Abstract: Display panel and display device are provided. The display panel includes an array substrate and a cover plate disposed opposite to the array substrate, touch electrode layers on a side of the cover plate facing the array substrate, and a plurality of first touch pads and a plurality of second touch pads disposed opposite to the plurality of the first touch pads. Each of the array substrate and the cover plate include a display area and a non-display area at least partially surrounding the display area. The non-display area of the array substrate includes a step area provided with bonding pads. The non-display area of the array substrate includes at least one irregularly-shaped area adjacent to the step area. A first touch pad is electrically connected to a second touch pad.

Abstract: The present disclosure relates to a fiber-reinforced copper-based brake pad for high-speed railway train, and preparation and friction braking performance thereof. The fiber-reinforced copper-based brake pad for high-speed railway train comprises 80-98.5 wt. % metal powder, 1-15 wt. % non-metal powder and 0.5-5 wt. % fiber component. In addition, some components are added in a specific proportion to achieve optimal performance. The copper-based powder metallurgy brake pad is obtained by powder mixing, cold-pressing and sintering with constant pressure. The friction braking performance of the obtained brake pad is tested according to a braking procedure consisting of three stages, i.e., the first stage with low-pressure and low-speed, the second stage with high-pressure high-speed and the continuous emergency braking third stage with high-pressure and high-speed.

Abstract: An operation method of a turbine fracturing device and a turbine fracturing device are provided. The turbine fracturing device includes a turbine engine, a speed reducer, a brake mechanism, and a fracturing pump, the method includes: driving, by the turbine engine, the fracturing pump to perform a fracturing operation through the speed reducer so as to keep the fracturing pump in an operating state, the fracturing pump being configured to suck fluid of a first pressure and discharge fluid of a second pressure, the second pressure being greater than the first pressure; and in response to an idling instruction, the turbine engine entering an idling state and triggering a brake operation so as to keep the fracturing pump in a non-operating state.

Abstract: Some embodiments of the present disclosure provide a power system and a fracturing device. The power system includes an oil tank, a reduction gearbox and a hydraulic system. The reduction gearbox is provided with a lubricating system, and the lubricating system is communicated with the oil tank. The hydraulic system includes a hydraulic actuating member, and the hydraulic actuating member is communicated with the oil tank.

Abstract: The present disclosure relates to the field of communications technologies, and discloses a channel quality information determining method, an apparatus, and a system. The method may include: a terminal device obtains a configured TBS, and/or determines channel quality information of each of K segments of frequency domain resources based on the configured TBS and/or a time domain resource range. A frequency domain resource of the terminal device may be divided into N segments, where both N and K are integers greater than or equal to 1, and K is less than or equal to N. In some embodiments, the configured TBS may be fully considered when the channel quality information is determined, so that a network device properly may determine, based on the channel quality information, a frequency domain resource used to transmit a data packet.

Abstract: A touch panel and a display apparatus are provided. The touch panel includes a first component region and a touch region, first-type touch electrode blocks, and m2 first connecting lines. First and second touch regions are respectively located at two sides of the first component region along a first direction. The first-type touch electrode blocks include first touch electrode blocks in the first touch region and second touch electrode blocks in the second touch region. m1 first touch electrode groups are arranged in the first touch region along a second direction. First connecting lines are respectively electrically connected to the first touch electrode groups and the second touch electrode blocks.