Abstract: The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n where n is 0, 1 or 2; R1, R2, R3, R4 and R5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4 and R5 may together form a methylenedioxy or ethylenedioxy moiety; R6, R7, R8 and R9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.

Abstract: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances.

Abstract: A microfluidic device (1) comprising a hydrophilic microchannel structure (2) in which there is a functional unit that comprises a microconduit I (17) in which there is an inlet end (16), an outlet end (18), and a capillary stop function I (24) in the form of a local non-wettable surface area (44). The capillary stop function (24) defines a segment of microconduit I (17). Microconduit I (17) is within at least a part of this segment (46) divided into two or more microchannels (42). A part of the non-wettable surface area (44a,b) is associated with an inner wall of each of the microchannels (42).

Abstract: A centrifugal-based microfluidic device (1) that comprises a hydrophilic microchannel structure (2) in which there is a A) a separation microcavity I (4) that comprises i) a liquid inlet I (5), and ii) a liquid outlet I (6) that is at a level below the level of liquid inlet I (5) and above the level of the bottom (8) of the microcavity (4) thereby defining a lower part (4b) and an upper part (4a) of the microcavity (4), and B) a microconduit I (17) that has an inlet end I (16) directly connected to liquid outlet I (6), and an outlet end I (18) that is at a lower level than inlet end I (6). A capillary valve I (24) is associated with microconduit I (17). The flow direction through liquid outlet I (6) is directed upwards and/or liquid outlet I (6) is placed in a downwardly turned part of an inner wall of the separation microcavity (4), and/or the part of microconduit I (17) next to liquid outlet I (6) is directed upwards.

Abstract: A method for maintaining a current view of a cluster's membership comprising the steps of maintaining a list of member nodes and updating the list when a modification thereto is noticed by a first node by receiving a first update message from the first node in a second node, thereafter, sending a second update message from the second node to a third node to propagate the modification and sending to the first node a first confirm message from the second or the third node. A node member of a cluster capable of maintaining a first list of neighboring nodes, maintaining a second list of neighboring nodes sharing a current view therewith and ensuring that the first list matches the second by exchanging messages with neighboring nodes, wherein each message comprises topology information. Upon confirmation that both lists match, the node being capable of sending a confirmation message toward neighboring nodes.

Abstract: A pipe line for a turbocharger system for an internal combustion engine has at least one exhaust line for the evacuation of exhaust gases from the combustion chamber of the engine to the turbocharger system and at least one inlet line for the supply of air to the combustion chamber. The turbocharger system includes at least one turbine, which cooperates with at least one compressor to extract energy from the exhaust flow of the engine and pressurize the inlet air of the engine. To allow a compact installation with low pressure losses, the inlet line connects with a curved line section of an outlet from the compressor, at least a part-section of the curved line section having a non-circular cross section. A diffuser is placed less than five pipe diameters downstream of the curved line section.

Abstract: A microfluidic device comprising a hydrophilic microchannel structure in which there is a functional unit that comprises a microconduit which a) is intended for the transportation of liquid aliquots, and b) has an inlet end and an outlet end between which there is a capillary valve I, which preferably is based on the presence of a local non-wettable surface area. Microconduit I further comprises one or more additional capillary valves, typically one. At least one of the additional valves is upstream of capillary valve I, such as at the inlet end of the microconduit.

Abstract: The present invention relates to microfluidic systems using rotating microfluidic disc platforms comprising microchannel structures. More specifically, the present invention relates to a method and an arrangement for controlling magnetic particles in microchannel structures of a microfluidic device. The invention is based on the counterbalancing of the magnetic force and the centrifugal force on the beads when rotating the microchannel structures at different speeds close to an array of magnets.

Abstract: A node member of a cluster in a network comprising a plurality of nodes and a method related to the capabilities of the node, which is capable of maintaining a stable view of the cluster's membership, maintaining a list of neighboring nodes sharing a same updated view of the cluster's membership and receiving a confirmation message from a second node confirming that a new view received therein should replace the stable view and become a new stable view. The node is further capable of verifying that the new view is up to date in comparison to the same view and, if the new view is not up to date, discarding the confirmation message.

Abstract: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).

Abstract: An arrangement for a reciprocating internal combustion engines is provide that includes a reciprocating main piston and a smaller cell piston which works in cooperation with the main piston to vary the compression ratio of and igniting a fuel-air mixture in a homogenous compression ignition engine. An actuator controls movement of the smaller cell piston relative to movement of the main piston.

Abstract: A turbocharger system for an internal combustion engine having at least one exhaust line for evacuating exhaust gases from the combustion chamber of the engine and at least one inlet line for supplying air to the combustion chamber. A high-pressure turbine interacts with a high-pressure compressor forming a high-pressure turbo unit with a common rotation axis. A low-pressure turbine interacts with a low-pressure compressor forming a low-pressure turbo unit with a common rotation axis. The high-pressure turbo unit and the low-pressure turbo unit are serially placed with the rotation axes essentially concentric and with the high-pressure turbine and the low-pressure turbine placed adjacent to each other and coupled together by an intermediate piece configured as a flow duct. The low-pressure turbo unit (22) is attached to one part of the internal combustion engine, while the high-pressure turbo unit is attached to another part of the engine.

Abstract: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).

Abstract: Microstructure for fluids provided in a rotatable disc (D) having a U-shaped volume-defining structure (7) connected at its base to an inlet arm of a U-shaped chamber (10).

Abstract: Method of manufacturing a microscale nozzle, comprising the steps of forming a microscale channel in the top surface of a substrate, said microscale channel comprising an inlet end and a nozzle-end, depositing a nozzle-forming layer in a section of the microscale channel, and removing material from the substrate at the nozzle-end of the microscale channel to expose at least a portion of said nozzle-forming layer. The manufactured microscale nozzle may be used for transferring a liquid sample form a microchip fluidic system into an external analytical device.

Abstract: A microfluidic device which comprises two or more microchannel structures (set 1), each of which comprises a structural unit which comprises (i) one or more inlet microconduits, and (ii) an outlet microconduit downstream said one or more inlet microconduits, and (iii) a flow path for a liquid passing through either of said inlet microconduits and said outlet microconduit. The device is characterized in that each outlet microconduit in said two or more microchannel structures is a restriction microconduit. There may also be a microcavity between the inlet microconduit(s) and the restriction microconduit in each microchannel structure. Typically common flow control is used for driving a liquid flow within the device. The innovative design is useful for creating flow with low inter-channel variation with respect to the microchannel structures of the device.

Abstract: A flow through dispenser for the drop-wise dispensation of liquid which arrangement comprises: a housing (104) comprising: (i) a flow through microconduit (105) with an upstream end (106) and a downstream end (outlet) (107); and (ii) a dispenser orifice (108) between these two ends, and an inlet tube (110) which is attached to the upstream end (106) and provides an inlet (111) that can be connected to a liquid storage (112) for liquid (113) that is to be transported in flow through microconduit (105) and inlet tube (110) and/or dispensed through the orifice (108). The inner volume between the inlet and the downstream end is is ?10 ?l. An instrument set-up for drop-wise dispensation of liquid to target areas of a microdevice.

Abstract: A microfluidic device which comprises two or more microchannel structures (set 1), each of which comprises a structural unit which comprises (i) one or more inlet microconduits, and (ii) an outlet microconduit downstream said one or more inlet microconduits, and (iii) a flow path for a liquid passing through either of said inlet microconduits and said outlet microconduit. The device is characterized in that each outlet microconduit in said two or more microchannel structures is a restriction microconduit. There may also be a microcavity between the inlet microconduit(s) and the restriction microconduit in each microchannel structure. Typically common flow control is used for driving a liquid flow within the device. The innovative design is useful for creating flow with low inter-channel variation with respect to the microchannel structures of the device.

Abstract: The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n where n is 0, 1 or 2; R1, R2, R3, R4 and R5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4 and R5 may together form a methylenedioxy or ethylenedioxy moiety; R6, R7, R8 and R9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.

Abstract: The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen from O, N, S and (CH2)n, where n is 0, 1, 2, 3, 4, or 5, or a combination of these and may contain carbon-carbon multiple bonds and branched chains as well as alicyclic and heterocyclic groups; Q is H or OH; R1 and R2 can be either the same or different and are chosen from hydrogen or the residue of an aromatic group as listed in Scheme 1 and the pharmacologically active salts thereof