Abstract: Method of manufacturing a microscale nozzle (52), comprising the steps of forming a microscale channel (32) in the top surface (34) of a substrate (30), said microscale channel (32) comprising an inlet end (36) and a nozzle-end (38), depositing a nozzle-forming layer (50) in a section of the microscale channel (32), removing material from the substrate (30) at the nozzle-end (38) of the microscale channel (32) to expose at least a portion of said nozzle-forming layer (50). The manufactured microscale nozzle may be used for transferring a liquid sample form a microchip fluidic system into an external analytical device. Whereby the transfer is performed by droplet, spray or steam.

Abstract: Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel and an outlet channel, a cover plate positioned over the base plate to define the chambers and connecting channels. Means are incorporated in the cell growth chambers, for cell attachment and cell growth. In particular, the invention provides a rotatable disc microfabricated for performing cell growth and cell based assays. The apparatus and method can be used for the growth of cells and the detection and measurement of a variety of biochemical processes and products using non-invasive techniques, that is techniques which do not compromise the integrity or viability of cells.

Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.

Abstract: The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen from O, N, S and (CH2)n, where n is 0, 1, 2, 3, 4, or 5, or a combination of these and may contain carbon-carbon multiple bonds and branched chains as well as alicyclic and heterocyclic groups; Q is H or OH; R1 and R2 can be either the same or different and are chosen from hydrogen or the residue of an aromatic group as listed in Scheme 1 and the pharmacologically active salts thereof.

Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.

Abstract: This invention relates to a novel microfluidic device and methods of using this device to conduct in vitro studies on the reaction and effects of various compounds on cells. More particularly, it relates to a method for using stop flow in a microfluidic system to study the effect of compounds on individual cells.

Abstract: Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel for supplying liquid sample thereto and an outlet channel for removal of liquid sample therefrom, a cover plate positioned over the base plate to define the chambers and connecting channels, the cover plate being supplied with holes to provide access to the channels. Means are incorporated in the cell growth chambers, for cell attachment and cell growth. In particular, the invention provides a rotatable disc microfabricated for performing cell growth and cell based assays. The apparatus and method can be used for the growth of cells and the detection and measurement of a variety of biochemical processes and products using non-invasive techniques, that is techniques which do not compromise the integrity or viability of cells.

Abstract: The invention relates to a method and an arrangement for multicasting, i.e. point to multipoint transmission of a data packet. A packet is copied and transmitted to multiple addresses. In the multicasting arrangement, switch core and input and output port are connected to input and output links, respectively, for transmitting data packets. According to the invention, the input port is adapted to detect a multicasting packet received on an input link or from an output port and send the multicasting packet to an output port. The output port is adapted to detect the multicasting packet, copy the data packet, modify an address portion of the multicasting packet, send one packet on the output link and return one packet with the modified address portion to an input port. Preferably, the input port and the output port are integrated in a link interface having a direct channel for returning the data packet.

Abstract: Disclosed is a method for performing the steps of nucleic acid template purification, a thermocycling reaction and purification of the products of the thermocycling reaction characterised in that the steps take place sequentially in a microfluidic disc. Also disclosed is a microstructure for fluids comprising at least one inlet opening connected to a first chamber incorporating a means for purifying template nucleic acid which, in turn, is connected to a second chamber incorporating a means for a thermocycling reaction which, in turn, is connected to a third chamber incorporating a means for purifying products of the thermocycling reaction, and a microfluidic disc comprising a plurality of such microstructures.

Abstract: Microstructure for fluids provided in a rotatable disc (D) having a U-shaped volume-defining structure (7) connected at its base to an inlet arm of a U-shaped chamber (10).

Abstract: A method for dispensing droplets of a liquid to a microsystem in the form of a disc comprising a target area (TA0I) in its surface, said disc preferably being a microfluidic disc comprising a microchannel structure with an inlet port that is a target area (TA0I).

Abstract: An insulated conductor for high-voltage windings and electric machine, and rotating electric machine that use the insulated conductor. The insulated conductor is suitable for use in a high-voltage winding application for devices such as an electric machine and a rotating electric machine. A feature of the insulated conductor is that the conductor includes at least one strand, and an inner conductive layer that surrounds the at least one strand. An insulating layer surrounds the inner conductive layer, and an outer conductive layer surrounds the insulating layer. When arranged in this manner, and when the outer conductive layer is suitably configured to provide an equipotential surface, the insulated conductor provides relatively high resistance to breakdown when operating at high voltages.

Abstract: A microfluidic device in form of a disc comprising an MS-port for presentation of an MS-analyte to an EDI-MS apparatus, said MS-port

Abstract: A method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer.

Abstract: A microfluidic device which comprises two or more microchannel structures (set 1), each of which comprises a structural unit which comprises (i) one or more inlet microconduits, and (ii) an outlet microconduit downstream said one or more inlet microconduits, and (iii) a flow path for a liquid passing through either of said inlet microconduits and said outlet microconduit. The device is characterized in that each outlet microconduit in said two or more microchannel structures is a restriction microconduit. There may also be a microcavity between the inlet microconduit(s) and the restriction microconduit in each microchannel structure. Typically common flow control is used for driving a liquid flow within the device. The innovative design is useful for creating flow with low inter-channel variation with respect to the microchannel structures of the device.

Abstract: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).

Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.

Abstract: A microfluidic device comprising an MS-analyte presentation unit for a EDI-MS apparatus, said unit comprising an essentially planar support plate which on one side has one, two or more ports (MS-ports) comprising an area (EDI area) for presenting the MS-analyte to a mass spectrometer. The EDI area comprises a layer I of conducting material. The characteristic feature of the device is that layer (I) has a conductive connection and/or that there is a calibrator area in the proximity of the MS-port.

Abstract: The invention relates to a CAM/RAM memory device with a scalable and flexible structure. The device has a number of rows of memory cells. At least one address decoder is connected by word lines to the cells of the rows. Vertical bit lines for match data implement CAM functionality of the memory device. According to the invention a mask is implemented in a row of the memory cells, the mask affecting the match data on the bit lines. Preferably, the memory device is divided into segments with a mask at the top of each segment. By means of the present invention, masking is obtained by inserting masks as mask rows between the CAM rows. The mask rows are programmed by writing the mask row cells in the same way as the CAM cells. The mask rows operate directly on the bit lines for the whole underlying segment of rows. By means of this arrangement, the invention makes efficient use of the available silicon area. The memory device has a useful application as a device for handling address look-up, e.g.

Abstract: A method and an apparatus for treatment of a first liquid which is a plasma of human blood comprising cyclically feeding the first liquid and a second liquid to the treatment device, and measuring a component of the first and second liquids so that a ratio between the first and second liquids are determined by a measuring arrangement. The first and second liquids are transferred to predetermined collection points by initiating and terminating a collection of the first liquid during one of the feeding cycles based on the ratio between the first and second liquids. The volume of at least the first liquid conveyed to the treatment device is measured during one of the cycles by a volume measuring arrangement. A theoretical time is determined between the initiating and terminating of the collection of the first liquid.