Patents by Inventor Per Gisle Djupesland

Per Gisle Djupesland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130098362
    Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.
    Type: Application
    Filed: May 14, 2012
    Publication date: April 25, 2013
    Applicant: OptiNose AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
  • Patent number: 8327844
    Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: December 11, 2012
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20120260915
    Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.
    Type: Application
    Filed: September 25, 2011
    Publication date: October 18, 2012
    Applicant: OPTINOSE AS
    Inventor: Per Gisle Djupesland
  • Patent number: 8171929
    Abstract: A delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: at least one nosepiece unit (21) for insertion into one nasal cavity of a subject and comprising a nosepiece (25) for fitting to the respective nostril of the subject; and at least one delivery unit (23) which is operative to deliver a substance through the at least one nosepiece unit into the one nasal cavity of the subject, wherein the at least one delivery unit includes a substance supply unit (27) for delivering a substance and an actuation unit (29) which is operable to actuate the substance supply unit, either automatically or manually, in response to nasal exhalation or at least attempted nasal exhalation by the subject.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: May 8, 2012
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Keith McMurray Boden
  • Publication number: 20120090608
    Abstract: A delivery device for and method of delivering substance, the delivery device comprising: a delivery outlet from which substance is in use delivered; a gas chamber containing a gas and being of reducible volume, wherein a reduction in the volume of the gas chamber to a predeterminable volume acts to pressurize the contained gas to a predeterminable pressure; a seal element disposed between the gas chamber and the delivery outlet; and an opening mechanism configured, on reduction of the volume of the gas chamber to a predeterminable volume, to open the seal element, whereupon a gas flow from the gas chamber acts to deliver substance from the delivery outlet.
    Type: Application
    Filed: May 2, 2011
    Publication date: April 19, 2012
    Applicant: OptiNose AS
    Inventors: Per Gisle Djupesland, Matthew Egerton Young, Andrew Robert Fry, Christopher John Hurlstone
  • Patent number: 8146589
    Abstract: A nasal delivery device (11) for delivering substance to a nasal airway (1) of a subject, comprising: first and second nosepiece units (17, 19), each including a nosepiece (21, 23) for fitting to respective nostrils of a subject; at least one substance supply unit (13, 15) for supplying substance for delivery to the nasal airway (1) of the subject; and a valve unit (35, 37) for selectively fluidly connecting the at least one substance supply unit (13, 15) alternately to respective ones of the nosepiece units (17, 19).
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: April 3, 2012
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20120073571
    Abstract: A breath-actuated nasal delivery device, comprising: a mouthpiece through which a user in use exhales to actuate the delivery device; a nosepiece for fitting to a nostril of the user through which a substance is in use delivered; a substance supply unit actuatable to deliver a dose of a substance through the nosepiece; a loading unit operable to load the substance supply unit with an actuation force; and a release mechanism for enabling actuation of the substance supply unit in response to exhalation by the user through the mouthpiece; wherein the release mechanism comprises a locking unit which is movable: between a locking configuration in which the substance supply unit is locked in a non-actuated position when loaded by the loading unit and a release configuration in which the substance supply unit is actuatable by the loading unit, and a trigger member for releasing the locking unit from the locking configuration to the release configuration in response to exhalation by the user through the mouthpiece an
    Type: Application
    Filed: November 29, 2010
    Publication date: March 29, 2012
    Applicant: OPTINOSE AS
    Inventor: Per Gisle DJUPESLAND
  • Publication number: 20120006323
    Abstract: A nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 12, 2012
    Applicant: OPTINOSE AS
    Inventor: PER GISLE DJUPESLAND
  • Publication number: 20120000459
    Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a delivery unit comprising a substance supply unit and a nozzle unit including at least one nozzle fluidly connected to the substance supply unit for generating an aerosol spray for delivery to a nasal airway of the subject; and an aerosol interactor operable to interact with an aerosol spray as generated by the at least one nozzle.
    Type: Application
    Filed: December 20, 2010
    Publication date: January 5, 2012
    Inventor: Per Gisle Djupesland
  • Publication number: 20110318345
    Abstract: substances and the nasal administration thereof, in particular as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, in particular the posterior region of the nasal airway, and in particular the upper posterior region of the nasal airway, which includes the olfactory bulb, in particular in the treatment of neurological conditions and disorders.
    Type: Application
    Filed: September 15, 2009
    Publication date: December 29, 2011
    Applicant: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Patent number: 8047202
    Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject, can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: November 1, 2011
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20110259329
    Abstract: A breath-actuated delivery device includes a mouthpiece through which a subject in use exhales, an air channel which is in fluid communication with the mouthpiece, and a flexible diaphragm which is disposed in the air channel. The diaphragm provides for at least a restricted air flow through the air channel until a predeterminable actuation pressure is developed in the mouthpiece, and, on generation of the predeterminable actuation pressure in the mouthpiece, provides for an air flow through the air channel.
    Type: Application
    Filed: August 30, 2010
    Publication date: October 27, 2011
    Applicant: OptiNose AS
    Inventors: Per Gisle Djupesland, Martin Joseph Murphy, Stuart Brian William Kay, Andrew Gordon Pocock
  • Patent number: 7975690
    Abstract: The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: July 12, 2011
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20110126830
    Abstract: A delivery device for delivering a metered amount of substance, the delivery device comprising: a mouthpiece (17) through which a user in use exhales; an outlet (19) through which substance is in use delivered; a housing (21) fluidly connected to the mouthpiece and the outlet, such, that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit (25) which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.
    Type: Application
    Filed: November 28, 2007
    Publication date: June 2, 2011
    Applicant: OPTINOSE AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20110114087
    Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.
    Type: Application
    Filed: January 19, 2006
    Publication date: May 19, 2011
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner
  • Patent number: 7934503
    Abstract: A delivery device for and method of delivering substance, the delivery device comprising: a delivery outlet (7) from which substance (S) is in use delivered; a gas chamber (17) containing a gas and being of reducible volume, wherein a reduction in the volume of the gas chamber (17) to a predeterminable volume acts to pressurize the contained gas to a predeterminable pressure; a seal element (11) disposed between the gas chamber (17) and the delivery outlet (7); and an opening mechanism configured, on reduction of the volume of the gas chamber to a predeterminable volume, to open the seal element (11), whereupon a gas flow from the gas chamber (17) acts to deliver substance (S) from the delivery outlet (7).
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: May 3, 2011
    Assignee: Optinose AS
    Inventors: Per Gisle Djupesland, Matthew Egerton Young, Andrew Robert Fry, Christopher John Hurlstone
  • Publication number: 20110088691
    Abstract: A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device including: a nosepiece for fitting to a nostril of a subject; a substance supply unit for supplying a substance for delivery through the nosepiece; and a delivery prevention mechanism for preventing delivery of a substance through the nosepiece until the nosepiece is properly fitted to the nostril of the subject.
    Type: Application
    Filed: April 9, 2010
    Publication date: April 21, 2011
    Inventor: Per Gisle Djupesland
  • Publication number: 20110088690
    Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising : a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 21, 2011
    Applicant: OPTINOSE AS
    Inventors: Per Gisle Djupesland, Colin David Sheldrake
  • Publication number: 20110023869
    Abstract: A delivery device for delivering a metered amount of substance (L) in response to exhalation by a user, the delivery device comprising: a mouthpiece (5) through which the user in use exhales; an outlet (45) from which substance Is delivered; and a dispensing unit (35) which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member (37) which includes a cavity (39) for containing a metered amount of substance, an outlet nozzle (43) which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing (41) member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle.
    Type: Application
    Filed: November 28, 2007
    Publication date: February 3, 2011
    Applicant: OPTINOSE AS
    Inventor: Per Gisle Djupesland
  • Patent number: 7854227
    Abstract: A nasal delivery device and method are provided for delivering substance to a nasal airway of a subject, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject. The delivery device is characterized by: a nosepiece for fitting to a nostril of a subject; a delivery unit including a substance supply unit and a nozzle unit including at least one nozzle fluidly connected to the substance supply unit for generating an aerosol spray for delivery to a nasal airway of the subject; and an aerosol interactor operable to interact with an aerosol spray as generated by the at least one nozzle.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: December 21, 2010
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland