Patents by Inventor Per Gisle Djupesland

Per Gisle Djupesland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100300439
    Abstract: A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly (3) including a mouthpiece unit (9) which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit (5) which includes a nosepiece and contains a container containing particulate substance.
    Type: Application
    Filed: November 28, 2007
    Publication date: December 2, 2010
    Applicant: OPTINOSE AS
    Inventors: Per Gisle Djupesland, Colin David Sheldrake
  • Patent number: 7841337
    Abstract: A breath-actuated nasal delivery device, comprising: a mouthpiece through which a user in use exhales to actuate the delivery device; a nosepiece for fitting to a nostril of the user through which a substance is in use delivered; a substance supply unit actuatable to deliver a dose of a substance through the nosepiece; a loading unit operable to load the substance supply unit with an actuation force; and a release mechanism for enabling actuation of the substance supply unit in response to exhalation by the user through the mouthpiece; wherein the release mechanism comprises a locking unit which is movable: between a locking configuration in which the substance supply unit is locked in a non-actuated position when loaded by the loading unit and a release configuration in which the substance supply unit is actuatable by the loading unit, and a trigger member for releasing the locking unit from the locking configuration to the release configuration in response to exhalation by the user through the mouthpiece an
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: November 30, 2010
    Assignee: Optinose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20100288275
    Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece (47) for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit (16) which is operable to deliver the powdered substance through the nosepiece (47).
    Type: Application
    Filed: April 7, 2008
    Publication date: November 18, 2010
    Applicant: OPTINOSE AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner
  • Publication number: 20100282246
    Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece (17) for fitting to a nostril of a subject, wherein the nosepiece (17) comprises a tip element (25) which includes a delivery aperture (26) from which substance is in use delivered into the nasal cavity, and the tip element (25) is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece (17), with the delivery aperture (28) extending both laterally across the tip element (25) and along a longitudinal extent of the tip element (25); a nozzle (35) through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece (17), to the respective nasal cavity; and a delivery unit (37) for delivering substance through the nozzle (35) of the nosepiece (17).
    Type: Application
    Filed: April 7, 2008
    Publication date: November 11, 2010
    Applicant: OPTINOSE AS
    Inventors: Per Gisle Djupesland, Colin David Sheldrake
  • Publication number: 20100242959
    Abstract: A delivery device for providing therapeutic gas to the nasal airway of a subject, the delivery device comprising: a nosepiece (21) for fitting to one nostril of the subject; a mouthpiece (23) through which the subject in use exhales and which is fluidly connected to the nosepiece (21); and a scrubber (27) which is operative at least to reduce the concentration of at least one gas from an exhaled breath of the subject as delivered through the mouthpiece (23) and provide a gas flow to the nosepiece (21) which has an increased concentration of at least one other,” therapeutic gas which provides a therapeutic effect.
    Type: Application
    Filed: July 25, 2007
    Publication date: September 30, 2010
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner
  • Patent number: 7784460
    Abstract: A delivery device, in particular a breath-actuated nasal delivery device, for delivering substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: August 31, 2010
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Martin Joseph Murphy, Stuart Brian William Kay, Andrew Gordon Pocock
  • Patent number: 7740014
    Abstract: A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device including: a nosepiece for fitting to a nostril of a subject; a substance supply unit for supplying a substance for delivery through the nosepiece; and a delivery prevention mechanism for preventing delivery of a substance through the nosepiece until the nosepiece is properly fitted to the nostril of the subject.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: June 22, 2010
    Assignee: Optinose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20100057047
    Abstract: A nasal delivery device for and method of delivering substance to the middle meatus in a nasal cavity of a subject in the treatment of a condition, in particular an inflammatory or infectious condition, thereof, the delivery device comprising: a nosepiece unit (17) including a nosepiece (20) for fitting to a nostril of a subject and a nozzle (25) through which substance is in use delivered to the respective nasal cavity; and a delivery unit (29) for delivering substance through the nozzle of the nosepiece; wherein the delivery device is configured to provide for deposition of a significant fraction of the delivered dose on, around and in the vicinity of the middle meatus.
    Type: Application
    Filed: February 14, 2007
    Publication date: March 4, 2010
    Applicant: OptiNose AS
    Inventors: Per Gisle Djupesland, Colin David Sheldrake, Roderick Peter Hafner
  • Publication number: 20100051022
    Abstract: A delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: at least one nosepiece unit (21) for insertion into one nasal cavity of a subject and comprising a nosepiece (25) for fitting to the respective nostril of the subject; and at least one delivery unit (23) which is operative to deliver a substance through the at least one nosepiece unit into the one nasal cavity of the subject, wherein the at least one delivery unit includes a substance supply unit (27) for delivering a substance and an actuation unit (29) which is operable to actuate the substance supply unit, either automatically or manually, in response to nasal exhalation or at least attempted nasal exhalation by the subject.
    Type: Application
    Filed: February 14, 2007
    Publication date: March 4, 2010
    Applicant: OptiNose AS
    Inventors: Per Gisle Djupesland, Keith McMurray Boden
  • Publication number: 20090314293
    Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit (20, 24) including a nosepiece (17) for fitting to a nostril of a subject and a nozzle (45) through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasal valve, and expand the same in the sagittal plane; and a delivery unit (43, 49, 51) for delivering substance through the nozzle of the nosepiece.
    Type: Application
    Filed: March 6, 2007
    Publication date: December 24, 2009
    Applicant: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20090304802
    Abstract: A sustained release nasal formulation for delivery to a nasal cavity of a subject, wherein the formulation provides for sustained release of a substance, in particular nitric oxide (NO), to nasal mucosa within the nasal cavity so as to provide one or both of a therapeutic effect and promote normal nasal function, and a nasal delivery device and method relating thereto.
    Type: Application
    Filed: March 5, 2007
    Publication date: December 10, 2009
    Applicant: OptiNose AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner
  • Publication number: 20090293873
    Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, she substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.
    Type: Application
    Filed: February 23, 2006
    Publication date: December 3, 2009
    Applicant: OPTINOSE AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
  • Patent number: 7543581
    Abstract: A nasal delivery device for and a method of delivering at least one substance to a nasal cavity of a subject. The nasal delivery device and method includes a delivery unit comprising: a nosepiece for fitting to a nostril of a subject; a mouthpiece through which the subject in use exhales; a breath analyzer for analyzing the concentration of at least one component in exhaled air from an exhalation breath; and a substance supply unit for supply at least one substance, the substance supply unit including a control unit for controlling the same to control supply of at least one substance in response to the detected concentration.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: June 9, 2009
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20090101146
    Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.
    Type: Application
    Filed: December 19, 2008
    Publication date: April 23, 2009
    Inventor: Per Gisle Djupesland
  • Publication number: 20080289629
    Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a p
    Type: Application
    Filed: September 15, 2005
    Publication date: November 27, 2008
    Applicant: OPTINOSE AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
  • Publication number: 20080223363
    Abstract: An exhalation breath-actuated nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece (40) for fitting to a nostril of a subject; a mouthpiece (42) through which the subject in use exhales; and delivery unit (64), as one of a mechanical delivery pump (66) or a nebulizer (115), for delivering a substance to the nosepiece (40); and an actuation mechanism (74) for actuating the delivery unit in response to oral exhalation through the mouthpiece, and preferably when at least one or both of the pressure at or the flow rate through the nosepiece exceeds a predetermined threshold.
    Type: Application
    Filed: March 21, 2008
    Publication date: September 18, 2008
    Applicant: OPTINOSE AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20080163874
    Abstract: A breath-actuated nasal delivery device, comprising: a mouthpiece through which a user in use exhales to actuate the delivery device; a nosepiece for fitting to a nostril of the user through which a substance is in use delivered; a substance supply unit actuatable to deliver a dose of a substance through the nosepiece; a loading unit operable to load the substance supply unit with an actuation force; and a release mechanism for enabling actuation of the substance supply unit in response to exhalation by the user through the mouthpiece; wherein the release mechanism comprises a locking unit which is movable: between a locking configuration in which the substance supply unit is locked in a non-actuated position when loaded by the loading unit and a release configuration in which the substance supply unit is actuatable by the loading unit, and a trigger member for releasing the locking unit from the locking configuration to the release configuration in response to exhalation by the user through the mouthpiece an
    Type: Application
    Filed: December 27, 2007
    Publication date: July 10, 2008
    Applicant: OPTINOSE AS
    Inventor: Per Gisle DJUPESLAND
  • Publication number: 20080161771
    Abstract: An exhalation breath-actuated nasal deliver device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a mouthpiece through which the subject in use exhales; and delivery unit, as one of a mechanical delivery pump or a nebulizer, for delivering a substance to the nosepiece; and an actuation mechanism for actuating the delivery unit in response to oral exhalation through the mouthpiece, and preferably when at least one or both of the pressure at or the flow rate through the nosepiece exceeds a predetermined threshold.
    Type: Application
    Filed: December 21, 2007
    Publication date: July 3, 2008
    Applicant: OPTINOSE AS
    Inventor: Per Gisle DJUPESLAND
  • Patent number: 7347201
    Abstract: An exhalation breath-actuated nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece (40) for fitting to a nostril of a subject; a mouthpiece (42) through which the subject in use exhales; and delivery unit (64), as one of a mechanical delivery pump (66) or a nebulizer (115), for delivering a substance to the nosepiece (40); and an actuation mechanism (74) for actuating the delivery unit in response to oral exhalation through the mouthpiece, and preferably when at least one or both of the pressure at or the flow rate through the nosepiece exceeds a predetermined threshold.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: March 25, 2008
    Assignee: Optinose AS
    Inventor: Per Gisle Djupesland
  • Publication number: 20050072430
    Abstract: The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
    Type: Application
    Filed: June 12, 2002
    Publication date: April 7, 2005
    Inventor: Per Gisle Djupesland